Beta-Blockers and Bone Health


About this study

The proposed study will directly examine whether bone mineral density (BMD) and bone microstructure are better preserved among HF patients on chronic β-blockers and account for the reports of decreased fracture. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Olmsted County residents
  • Age ≥50 yrs
  • History of HF diagnoses and either:
    • have been on β-blockers for at least 1 year
    • have not received chronic β-blockers for at least the past 3 years
  • Age and sex matched controls who do not have HF and who have not received chronic β-blockers for the past 3 years
  • Eligible women will be postmenopausal for at least 1 year

Exclusion Criteria:

  • Current or past history of malignancy that has required chemotherapy
  • Chronic renal insufficiency (GFR<30)
  • Bilateral hip replacements/pinning
  • History of current or past chronic glucocorticoid use (>3 months)
  • On pharmacologic doses of thyroid replacement
  • Current users of teraparatide, denosumab, oral or IV bisphosphonates, calcitonin, oral hormone replacement therapy (HRT), selective estrogen receptor modulators (SERMs), aromatase inhibitors in past 12 months, or androgen blockers   
  • Subjects who are not ambulatory

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Shreyasee Amin, M.D., C.M., M.P.H.

Closed for enrollment

More information


Publications are currently not available

Additional contact information

Non-cancer trials contact form

Phone: 800-664-4542 (toll-free)

International patient clinical studies questions