Inherited Breast Cancer Study


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 14-001806
    • Jacksonville, Florida: 14-001806
    • Scottsdale/Phoenix, Arizona: 14-001806
    Sponsor Protocol Number: 14-001806

About this study

The purpose of this study is to improve the interpretation of mutations in breast cancer predisposition genes. This will be accomplished by recruiting members of families found to carry deleterious (mainly protein truncating) mutations and evaluating co-segregation of the mutations with cancer within families.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Females and males between the ages of 18 and 90. 
  • Family or personal history of cancer and/or a family or personal history of genetic variants (deleterious or variant of unknown significance) in cancer predisposition genes.
  • Participants may also be those who have tested negatively for genetic variants in cancer predisposition genes.

Exclusion Criteria:

  • This project does not involve prisoners or children.


Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Fergus Couch, Ph.D.

Open for enrollment

Contact information:

Department of Health Sciences

(855) 371-7673

Jacksonville, Fla.

Mayo Clinic principal investigator

Fergus Couch, Ph.D.

Contact us for the latest status

Contact information:

Stephanie Hines M.D.


Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Fergus Couch, Ph.D.

Contact us for the latest status

Contact information:

Donald Northfelt M.D.


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

Additional contact information

Cancer-related trials contact form

Phone: 855-776-0015 (toll-free)

International patient clinical studies questions