Mucosal Interactions in Celiac Disease


About this study

To obtain biopsies and blood from subjects not previously known to have celiac disease who are undergoing duodenal biopsies for clinical indications. The subjects will have no prior diagnosis of celiac disease and are eating a gluten-containing diet. The biopsies will be treated “in vitro” with enzymatic digests of gluten derived from bread made from different species of wheat, the auto-antigen tTg, cytokines, or other proteins.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • No prior diagnosis of celiac disease
  • Have not been treated with a gluten free diet
  • Consent to study
  • Undergoing endoscopy for diagnostic/follow-up purposes

Exclusion Criteria:

  • Patients under the age of 18 and elderly patients (over 80)
  • Regarding pregnant women, we will only be collecting biopsies if the patient has a clinical endoscopy scheduled. 
  • Patients on anticoagulants at the time of the endoscopy
  • Individuals who took either antibiotics or probiotics two weeks prior to the scheduled biopsy

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Joseph Murray, M.D.

Closed for enrollment

Contact information:

Carol Van Dyke CCRP

(507) 266-7842

More information


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