Echocardiographic Measures of Pulmonary Vascular Distensibility and Effects on Lung Diffusing Capacity
Tab Title Description
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Rochester, Minnesota: 16-000149
Sponsor Protocol Number: 16-000149
About this study
The purpose of this study is to determine if the change in pulmonary vascular compliance with positional changes (upright, supine, and Trendelenburg position) is different in younger versus older individuals.
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Group 1: 12 young (18-34y) healthy individuals; males and females Group 2: 12 old (>65y) healthy individuals; males and females
- No history of cardiac, pulmonary, or metabolic disorders
- Body Mass Index (BMI) < 30
- Normal pulmonary function (>80% predicted)
- Blood pressure <150/90
- Adequate TR jet during echocardiographic screening
- Women who are pregnant
- History of cardiac, pulmonary, or metabolic disorders
- Body Mass Index (BMI) > 30
- Lower than normal pulmonary function (<80% predicted)
- History of smoking
- Blood pressure >150/90
- Inadequate TR jet during echocardiographic screening
- Medications: Nitrates
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
|Mayo Clinic Location
Mayo Clinic principal investigator
Bruce Johnson, Ph.D.
Closed for enrollment
Publications are currently not available
Study Results Summary
Not yet available
Supplemental Study Information
Not yet available