Exploring Possible Mechanisms that Might Explain Potential Vasodilator and Sensory Effects of TJ-68


About this study

We will determine if a) glycyrrhetic acid (GA, a key component of TJ-68) evokes vasodilation, and b) if glycyrrhetic acid alters the TRP mediated sensory response to local heating. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Healthy subjects between 18-40 years old
  • Non-obese 
  • Non-smokers

Exclusion Criteria:

  • Hypertension 
  • Hyperlipidemia 
  • Smoking 
  • Heart disease 
  • Diabetes Autonomic disorders   
  • Other conditions or medications that might normally alter exercise capacity or responses)

All inclusion and exclusion criteria are at the discretion of the Principal Investigator. 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Closed for enrollment

More information


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Additional contact information

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Phone: 800-664-4542 (toll-free)

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