Bile Acids, Genetic Control and Ileo-Colonic Mucosal Expression in IBS-D
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 16-001445
Sponsor Protocol Number: 16-001445
About this study
The purpose of this study is to understand the role of genetics (inherited genes from biological parents) and expression of genes and proteins in the lining of the intestine and colon in the development of diarrhea in patients with irritable bowel syndrome with or without bile acid malabsorption.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion criteria Asymptomatic controls IBS patients
Age (yr) 18-75 18-75
Gender (F:M) 10:1 10:1
BDQ - IBS symptoms -ve by Rome III criteria +ve by Rome III criteria
Hospital Anxiety/Depression score <8 No restrictions
Abdominal surgery (except appy or choly) None None
GI medications None past 6 months None past 48h
Exclusion criteria
In all patients diagnosed with IBS, we apply rigorous standards to exclude clinically-relevant inflammation. Patients with known bleeding diathesis will be excluded, given the need for sigmoid mucosal biopsies. Anyone with a known allergy to Midazolam and Fentanyl for Aim 2 in protocol and named medications.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
More information
Publications
Publications are currently not available