A Study to Demonstrate that Acetazolamide is not Inferior to Diazepam for Patients who have Continuous Spike and Wave Brain Pattern in Sleep


About this study

The purpose of this study is to compare the effectiveness of the medications acetazolamide and diazepam for the treatment of patients who have continuous spike wave brain pattern in sleep or Landau-Kleffner syndrome.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Child, age 3-12 years inclusive
  • ESES and clinical CSWS/LKS defined by all of the following (confirmed during inpatient PEMU evaluation)
    • SWI ≥50% during first hour of sleep
    • Bilateral synchrony of discharges during sleep
    • Clinical evidence of behavior and/or academic regression
    • Daytime SWI ≤20%

Exclusion Criteria

  • Previous treatment with benzodiazepine or acetazolamide for ESES
  • Current treatment with carbamazepine, phenytoin, oxcarbazepine, phenobarbital, vigabatrin
  • AED medication changes over the month prior to enrollment
  • Epileptic encephalopathy other than CSWS/LKS
  • Prior serious adverse reaction to benzodiazepines or acetazolamide
  • Sulfa allergy
  • Progressive underlying neurologic condition
  • Frequent seizures that would prevent the patient from maintaining a stable dose of medications
  • Has begun menstruation (risk of pregnancy)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Katherine Nickels, M.D.

Closed for enrollment

More information


Publications are currently not available

Additional contact information

Non-cancer trials contact form

Phone: 800-664-4542 (toll-free)

International patient clinical studies questions