Cardiovascular Effects of Adderall in Healthy Young Adults


About this study

The purpose of this study is to determine blood pressure and heart rate changes (hemodynamic changes) in healthy adults after taking one dose of prescription medication Adderall 25 mg orally, and comparing the results to those of  a placebo pill. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:          

  • Adults 18 years of age and older
  • Healthy subjects without known cardiovascular disease, thyroid disease or documented mental health illness
  • Subjects who are not on any medications
  • Subjects with no prior history of regular amphetamine use, and non-prescription stimulants
  • Nonsmokers

Exclusion Criteria:         

  • Subjects with known cardiovascular disease, thyroid disease
  • Subjects with history of psychotic disorders/mental health illness, including but not limited to anxiety, depression, bipolar disorder; history of substance abuse or dependence
  • Subjects currently taking medications
  • Prior history of regular amphetamine use, or non-prescription stimulants
  • Smokers
  • Pregnant subjects
  • Known lactose intolerance (due to presence of lactose in the prepared medication)
  • Family history of sudden cardiac death

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Anna Svatikova, M.D., Ph.D.

Closed for enrollment

Contact information:

Sleep and Cardiovascular Clinical Research Unit

More information


Publications are currently not available