Study of Awareness and Detection of Familial Hypercholesterolemia (CASCADE-FH)


About this study

The CASCADE Familial Hypercholesterolemia Registry will track therapy, clinical outcomes, and patient-reported outcomes over time aiming to increase familial hypercholesterolemia awareness, promote optimal disease management, and improve outcomes. This study is not recruiting family members of FH patients at this time.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria - Online Patient Enrollment:

  • Patients with existing clinical diagnosis of Familial Hypercholesterolemia (FH).
  • Patients with genetic mutation of FH.
  • Patients with an initial (pretreatment) LDL level > 190 mg/dL or total cholesterol > 300 mg/dL.
  • Patients currently taking a lipid-lowering medication and have an LDL > 124 mg/dL or total cholesterol > 195 mg/dL.

Inclusion Criteria - Clinic Patient Enrollment:

  • Patients with existing clinical diagnosis of FH using one of the three clinical diagnostic (US MedPed Program Criteria:
    • Simon Broome Register Criteria with diagnosis of "Probable";
    • Dutch Lipid Clinic Network Diagnostic Criteria with diagnosis of "Probable") tools for FH; or
    • Patients with genetic mutation of FH.

Exclusion Criteria:

  • Have a known medical condition other than FH that is thought to contribute to hyperlipidemia (i.e., untreated hypothyroidism, nephrotic syndrome, cholestasis hypopituitarism).

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Iftikhar Kullo, M.D.

Open for enrollment

Contact information:

Iftikhar Kullo M.D.


More information


Publications are currently not available