A Study to Evaluate the use of Real Time Myocardial Perfusion Echocardiography for Detection of Coronary Allograft Vasculopathy in Heart Transplant Patients


About this study

The purpose of this study is to see if the use of real time ultrasound of heart muscle perfusion is a usable and effective non-invasive way to detect Coronary Allograft Vasculopathy (heart transplant caused blood vessel disease) in child and adult heart transplant patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Cardiac transplant recipients (>10 months post transplant)
  • Clinically followed at Mayo Clinic (Rochester Mn)

Exclusion Criteria

  • Standard contraindications to the use of ultrasound contrast and pharmacologic stress
  • Recent (<3 months) hospitalization for heart failure, acute coronary syndrome or allograft rejection
  • Multi-organ transplant
  • Known or suspected right-to-left, bi-directional or transient right-to-left cardiac shunts
  • Hypersensitivity to perflutren

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Jonathan Johnson, M.D.

Closed for enrollment

More information


Publications are currently not available

Additional contact information

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Phone: 800-664-4542 (toll-free)

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