A Study of the Quantiferon CMV Blood Test to Predict the Risk of CMV Returning After Treatment of the Disease in Solid Organ Transplant Recipients

Overview

About this study

The purpose of this study is to determine if a special laboratory test performed on a blood sample collected from you (the organ recipient) can accurately predict the risk CMV infection occurring again in the future, after the current disease is cured.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria:

  • Patients older than 18 years old, with solid organ transplant (kidney, heart, lung, pancreas or liver).
  • Patients that have been identified of having CMV disease (syndrome or tissue invasive disease) by the above definitions
  • Patients that will require induction antiviral therapy (with ganciclovir, cidofovir, foscarnet or valganciclovir at induction doses) until 2 weekly CMV viral quantification tests by PCR are negative and who will be transitioned to secondary antiviral prophylaxis.
  • Patients that provide informed consent to obtain blood samples for QuantiFERON-CMV testing at the above mentioned time points.

 

Exclusion criteria:

  • Documented episodes of CMV disease prior to the one at the time of inclusion to the study
  • Patients with asymptomatic CMV infection (that did not require the use of induction antiviral therapy)

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Raymund Razonable, M.D.

Closed for enrollment

Contact information:

Maria Dioverti Prono M.D.

(507)255-7763

DiovertiProno.Maria@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available