The MOTS (Medication Overuse Treatment Strategy) Trial

Overview

About this study

There are two commonly used treatment strategies for treating patients who have chronic migraine with medication overuse. This study will compare the outcomes amongst patients randomized to one of the two treatment strategies.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Adults, at least 21 years of age
  • Chronic Migraine diagnosed according to ICHD3beta criteria
  • Medication Overuse diagnosed according to ICHD3beta criteria
  • Willingness to be randomized to either of the two treatment arms
  • Willingness to maintain a headache diary
  • Plan for follow-up care with the clinician
  • No changes to migraine prophylactic therapy within the 4 weeks prior to randomization

Exclusion Criteria

  • Younger than 21 years of age
  • Headache diagnoses other than chronic migraine with medication overuse
    • Episodic tension-type headache on 3 or fewer days per month is allowed
  • Not willing to be randomized to either of the treatment arms
  • Not willing to maintain a daily headache diary
  • Not planning on follow-up care with the clinician
  • In the opinion of the clinician, randomization to either treatment arm would be considered unsafe (EX pregnancy, immediate discontinuation)
  • Prisoners
  • Diminished decision-making capacity which in the investigator's opinion would interfere with the ability to provide informed consent and complete study procedures

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Fred Cutrer, M.D.

Open for enrollment

Contact information:

Carey Huebert B.S.

(507) 293-1120

Huebert.Carey@mayo.edu

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Todd Schwedt, M.D.

Open for enrollment

Contact information:

Teresa Radam CCRP

(480)342-3775

radam.teresa@mayo.edu

Jacksonville, Fla.

Mayo Clinic principal investigator

Todd Schwedt, M.D.

Open for enrollment

Contact information:

Sabrina Selman C.C.R.C.

(904)953-8030

Selman.Sabrina@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available