Evaluating Stem Cell Function in Patients with Chronic Kidney Disease (CKD)


About this study

New treatments of the future may use stem cells, cells that naturally occur in our blood or belly/abdominal fat, to help people with kidney disease.  The purpose of this study is to understand the function of specific cell types and how well they may work to repair our kidneys.  Two cell groups, mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), will be examined.  Study participants will include individuals with varying degrees of kidney function and potential causes of kidney disease.  This information will help plan for future studies using stem cells to treat kidney disease.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age between 18 to 100 years.
  • Ability to provide consent and complete all aspects of the study.

Exclusion Criteria: 

  • Pregnant.
  • Evidence of hepatitis B or C, or HIV infection (this will be assessed through the EMR).
  • Solid organ transplantation.
  • Nephrotic syndrome.
  • Immunosuppression therapy.
  • Active glomerulonephritis.
  • HbA1c ≥ 11%.
  • Subjects on therapeutic doses of anticoagulants [Warfarin (Coumadin), Rivaroxaban (Xarleto); Apixaban (Eliquis); Dabigatran (Pradaxa, Prazaxa)].
  • History of substance abuse (including alcohol) within the past 2 years.
  • Active substance abuse (>3 alcoholic beverages/day or>21 per week).
  • Body weight >150 kg or BMI >50.
  • Uncontrolled psychiatric disorder.
  • Presence of any condition that the Investigator believes would put the subject at risk or would preclude the patient from successfully completing all aspects of the trial.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Latonya Hickson, M.D.

Open for enrollment

Contact information:

Tammie Volkman R.N.



More information


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