A Study Comparing Changes in Lung Diffusing Capacity, Cardiac Output, and Pulmonary Vascular Pressures During Exercise in Younger versus Older Individuals
About this study
The purpose of this study is to determine and compare changes in lung diffusing capacity, cardiac output, and pulmonary vascular pressures during exercise for younger versus older individuals. It is possible that the blood vessels of the lungs play a greater role in unexplained exercise intolerance and shortnesss of breath in older individuals than previously thought.
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.See eligibility criteria
- BMI ≤ 35
- Normal pulmonary function (FVC, FEV1)
- No history of cardiovascular, cardiorespiratory, or metabolic disease
- Women who are pregnant
- History of smoking (> 5 pack years)
- BMI > 35
- Lower than normal pulmonary function
- < 80% pred FVC
- < 80% pred FEV1
- History of cardiovascular, cardiorespiratory, or metabolic disease
- Unable to exercise normally due to orthopedic or other reasons
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
|Mayo Clinic Location
Mayo Clinic principal investigator
Bruce Johnson, Ph.D.
Closed for enrollment