A Study Comparing Changes in Lung Diffusing Capacity, Cardiac Output, and Pulmonary Vascular Pressures During Exercise in Younger versus Older Individuals


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 15-002362
    Sponsor Protocol Number: 15-002362

About this study

The purpose of this study is to determine and compare changes in lung diffusing capacity, cardiac output, and pulmonary vascular pressures during exercise for younger versus older individuals. It is possible that the blood vessels of the lungs play a greater role in unexplained exercise intolerance and shortnesss of breath in older individuals than previously thought.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria

  • Non-smoker
  • BMI ≤ 35
  • Normal pulmonary function (FVC, FEV1)
  • No history of cardiovascular, cardiorespiratory, or metabolic disease

Exclusion Criteria

  • Women who are pregnant
  • History of smoking (> 5 pack years)
  • BMI > 35
  • Lower than normal pulmonary function
    • < 80% pred FVC
    • < 80% pred FEV1
  • History of cardiovascular, cardiorespiratory, or metabolic disease
  • Unable to exercise normally due to orthopedic or other reasons

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Closed for enrollment

Additional contact information

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Phone: 800-664-4542 (toll-free)

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