A Study of the Effect of Exercise on Cardiac Hemodynamics After Adjusting Atrial-Ventricular and Interventricular Timing Delays in Patients with a CRT (Cardiac Resynchronization Therapy) Device


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 12-003148
    Sponsor Protocol Number: 12-003148

About this study

The purpose of this study is to determine the resuts of adjusting atrial-ventricular (AV) and interventricular (VV) timing delays on cardiac hemodynamics at rest and during exercise for patients who have a CRT (cardiac resynchronization therapy) device. Most current attempts to optimize CRT are done under resting conditions and patients report symptoms during mild daily exercise.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria

  • Heart failure patients 
  • Either already have a CRT device (≤ 3 mo.) or are undergoing clinically indicated CRT device implantation
  • Ages 30-80 years
  • Are able to perform very light exercise without orthopedic limitations 
  • Not morbidly obese (BMI>38)

Exclusion Criteria

  • Not able to perform light exercise with orthopedic limitations (and not morbidity obese)

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Closed for enrollment

Additional contact information

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