A Study Identifying Blood Serum Markers of the Immune System Affecting Different Features of Chronic Rhinosinusitis


About this study

The purpose of this study is to find out what immune system processes cause the chronic inflammation that happens with chronic rhinosinusitis (CRS) and if there are different immune system pathways involved among CRS patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Age 18 years and older.
  • Both males and females
  • Meet clinical definition of CRS
    • nasal obstruction
    • facial congestion
    • facial pain-pressure-fullness
    • decrease in sense of smell
  • Presence or absence of  nasal polyps as evidenced by a CT scan or rhinoscopy


Exclusion criteria (history suggestive or presence of)

  • Cystic fibrosis
  • Primary ciliary dyskinesia
  • Primary immune deficiency disorder
  • Pregnant at time of clinic visit
  • Cigarette smoking in the last 6 months
  • SNOT-22 scores greater than 21 (to exclude those currently in exacerbation)
  • Oral corticosteroids in the past 2 weeks before visit
  • Intramuscular corticosteroids in the past 6 weeks before visit



Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Rohit Divekar, M.B.B.S., Ph.D.

Closed for enrollment

More information


Publications are currently not available

Additional contact information

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Phone: 800-664-4542 (toll-free)

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