A Study Identifying Blood Serum Markers of the Immune System Affecting Different Features of Chronic Rhinosinusitis

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 14-001630
    Sponsor Protocol Number: 14-001630

About this study

The purpose of this study is to find out what immune system processes cause the chronic inflammation that happens with chronic rhinosinusitis (CRS) and if there are different immune system pathways involved among CRS patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

Inclusion Criteria

  • Age 18 years and older.
  • Both males and females
  • Meet clinical definition of CRS
    • nasal obstruction
    • facial congestion
    • facial pain-pressure-fullness
    • decrease in sense of smell
  • Presence or absence of  nasal polyps as evidenced by a CT scan or rhinoscopy

 

Exclusion criteria (history suggestive or presence of)

  • Cystic fibrosis
  • Primary ciliary dyskinesia
  • Primary immune deficiency disorder
  • Pregnant at time of clinic visit
  • Cigarette smoking in the last 6 months
  • SNOT-22 scores greater than 21 (to exclude those currently in exacerbation)
  • Oral corticosteroids in the past 2 weeks before visit
  • Intramuscular corticosteroids in the past 6 weeks before visit

 

 

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Rohit Divekar, M.B.B.S., Ph.D.

Open for enrollment

Contact information:

Kay Bachman R.N., C.C.R.C.

(507)284-5689

bachman.kay@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20151602

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