A Study to Learn the Effect of Changes in Oxygen Levels on Changes in Blood Sugar


About this study

The purpose of this study is to see how changes in the amount of oxygen breathed can affect how the body responds to changes in blood sugar.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • healthy adult men and women
    • We will attempt to enroll an equal number of males and females
  • 18-35 years of age
  • BMI <30 kg/m2
  • non-pregnant
  • non-smokers 
  • subjects must consume at least 200 grams of carbohydrates per day and their customary diets meet ADA guidelines for protein, fat, and carbohydrates during the study
    • A brief dietary history will be taken at the time of screening

Exclusion Criteria

  • hepatic disease
  • renal disease
  • hematological disease
  • peripheral vascular disease
  • stroke
  • diabetes
  • hypertension
  • hyperglycemia
  • dyslipidemia 
  • sleep apnea
  • neurological disorders
  • bleeding/clotting disorders
  • debilitating chronic disease
  • any symptom of undiagnosed illness
  • history of alcoholism, or substance abuse
  • Medications that may affect glucose handling
    • corticosteroids
    • tricyclic-antidepressants
    • benzodiazepines
    • opiates
    • barbiturates
    • anticoagulants
  • Individuals who perform aerobic exercise for more than 40 min 3-4 times per week will be excluded because intensive exercise training may change outcome variables
  • Women must have a negative pregnancy test within 48 hours of the study

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Timothy Curry, M.D., Ph.D.

Closed for enrollment

More information


Publications are currently not available

Additional contact information

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Phone: 800-664-4542 (toll-free)

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