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Center for Individualized Medicine

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Programs

The Center for Individualized Medicine's translational and infrastructure programs position Mayo Clinic as a global leader in precision medicine research, practice and education by providing real-time information and resources to health care providers.

Translational programs bring personalized medicine discoveries to patient care. These programs include:

Clinomics
Epigenomics
Microbiome
Pharmacogenomics
Precision Cancer Therapeutics
Translational Omics

Infrastructure programs provide technical resources, expertise and services that ensure the most recent information and processes are available to all medical providers, whether they're treating patients at Mayo Clinic or around the world. The center's infrastructure programs include:

Bioethics
Bioinformatics
Biorepositories
Education
Information Technology

Bioethics Program

The Bioethics Program develops strategies for ethically integrating genomic technologies into health care, while always prioritizing the best interests of the patient. Program activities include providing ethics consultations and education, supporting community advisory boards, engaging the larger community, and providing national leadership on ethical issues in genomic medicine.

Bioinformatics Program

The Bioinformatics Program supports individualized medicine research by taking "raw" genomic sequencing data and processing, analyzing and interpreting it, ultimately leading to personalized tests and treatments for patients.

Biorepositories Program

The Biorepositories Program maintains several biospecimen collections — including the 50,000-plus participant Mayo Clinic Biobank — and provides laboratory services to investigators at Mayo Clinic, in industry and at other research institutions. This program supplies specimens to precision medicine researchers that advance genomic and molecular discovery and clinical translation.

Clinomics Program

The Clinomics Program accelerates the translation of discoveries from the research lab to patient care by integrating genomic data into clinical systems and creating new tools that enable doctors to access, visualize and use genomic information. Clinicians and scientists collaborate with multidisciplinary experts to advance health care for cancer, rare and undiagnosed diseases, and predictive testing for possible future health concerns.

Education Program

The Center for Individualized Medicine educates care teams, researchers, patients and communities about how genomic information can be used to improve health care. The program helps build the precision medicine workforce of the future by training current and future members of the health care team to become expert providers of world-class individualized patient care.

Epigenomics Program

The Epigenomics Program examines factors outside of DNA that can change the structure of the DNA or influence how genes are expressed. These factors include proteins near the DNA helix as well as environmental factors such as diet; lifestyle; and exposure to pollution, chemicals or radiation. Characterizing these factors and their effects will help patients reduce risk factors for disease and allow scientists to pinpoint new molecular targets for diagnosis and therapy.

Information Technology Program

The Information Technology Program provides resources to support the center's next-generation sequencing, including high-speed servers for identifying genomic variants and storing millions of gigabytes of data. The program also develops applications for validating and optimizing new laboratory tests and managing clinical trials.

Microbiome Program

The Microbiome Program studies how the naturally occurring bacteria populations in each person's body help maintain health and how disrupting these bacteria can lead to health problems. Researchers are finding ways to manipulate the microbiome to treat diseases and conditions such as colon cancer, clostridium difficile infection and irritable bowel syndrome.

Pharmacogenomics Program

The Pharmacogenomics Program studies how specific drugs react with individual patients' genes to identify the right medication for the right person at the right time and dose. Researchers are translating discoveries into patient care by embedding drug-gene best-practice alerts in the electronic health record and using drug-gene testing in clinical treatment studies for patients with breast cancer, prostate cancer or coronary artery disease.

Precision Cancer Therapeutics Program

The Precision Cancer Therapeutics Program facilitates rapid translation of genomics-based cancer therapies into the clinical practice. The program brings together specialists in cancer biology, cancer therapeutics, genomics and other areas to identify the most promising therapeutic targets and quickly move them into the clinic as clinical studies, that if successful, have the potential to transform care for patients with cancer.

Translational Omics Program

The Translational Omics Program analyzes multiple types of omic data to interpret the results of genetic testing and apply findings to patient care. When tests detect genetic changes, researchers use the results to try to identify the causes of previously undiagnosed diseases and develop new treatment strategies to improve care for patients with previously unmet needs.

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