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Talk to your health care provider about scheduling the PGx Profile.

Pharmacogenomic PGx

What is Pharmacogenomics (PGx)?

PGx is the study of how your genes may affect your body's response to, and interaction with, some prescription or over-the-counter medications.

Genes, which are inherited from your parents, carry information that determine characteristics such as eye color and blood type. Genes can also influence how you process and respond to medications.

Depending on your genetic make-up, some medications may work faster or slower, or produce more or fewer side effects.

Why is PGx important?

What factors impact response to medications?

PGx testing is one tool your healthcare provider can use to help identify the right drug for you. Many factors impact how a person responds to medication including:

  • Genetic factors
  • Age
  • Sex
  • Race/ethnicity
  • Illness or organ dysfunction, especially kidney or liver function
  • Smoking/alcohol
  • Food interactions
  • Other medications

When might PGx testing be recommended or considered?

There are different reasons why your healthcare provider might order PGx testing to help guide your current or future medication use, such as:

  • To avoid or prevent serious side effects related to certain medications
  • To adjust the dose of a current medication or recommend a different medication
  • To identify a medication, or dose of a medication, most likely to work for you before you take it

How much will it cost?

The cost varies depending on which test(s) is ordered. Depending on your policy and reasons for testing, some insurance companies may cover pharmacogenomic testing. Contact your insurance provider about coverage prior to testing if this is a concern.

In addition to PGx testing costs, patients will incur charges related to the appointment/visit with their providers and those charges may vary.

Will PGx testing affect insurance coverage?

GINA, the Genetic Information Nondiscrimination Act, prohibits medical insurance companies and employers from discriminating against individuals on the basis of genetic information, including PGx test results.

Pharmacogenomics Genes and Drugs

Richard Weinshilboum, M.D., director, Pharmacogenomics Program

Individualized Medicine — Andrew's Story

Applied pharmacogenomics resolves a patient's lifelong anxiety and depression.

Pharmacogenomics Program Animation

The Pharmacogenomics Program investigates how variations in genes affect response to medications, thereby using a patient's genetic profile to predict a drug's efficacy, guide dosage and improve patient safety.

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The Center for Individualized Medicine is a strategic priority for the Campaign for Mayo Clinic.

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