Molecular Pharmacology and Experimental Therapeutics

Making a Difference
Imagine a career that melds the unparalleled thrill of discovering basic biological mechanisms with the excitement of translating those findings into the novel therapies for human diseases.

In other words, "basic science on steroids" ... an environment in which you not only perform cutting-edge basic research that leads to new insights in biology, but you also see how your discoveries can make a difference.

If this appeals to you, consider Mayo Clinic's Molecular Pharmacology and Experimental Therapeutics Program (MPET), a unique and innovative Ph.D. training opportunity for graduate students looking to contribute to the frontiers of 21st century discovery and medicine.

"I hope to have a dual career encompassing both clinical care and basic science research. I know it is something that is particularly challenging and, if anything, becoming more difficult with time, but having a research mentor who does both, and by seeing other faculty members in Mayo Clinic Graduate School of Biomedical Sciences continue to do both, gives me hope that I can do the same."
—Andrew Landstrom - MPET Student

Extraordinary Mentors
Mayo MPET faculty members actively mentor students by guiding your research project, fostering your intellectual development as a scientist, developing your communication skills, and providing you with career advice, all with the goal of training you to become an independent investigator in academia or industry. They also are world-class scientists whose multidisciplinary research programs integrate across the fields of biochemistry, molecular biology, cell biology, organic chemistry, structural biology, and genetics. Most importantly, your independent graduate student research project will be a key component of these research programs, which include the areas of:

  • Cancer Biology and Therapeutics
    Be a part of the discovery of the molecular underpinnings that drive cancer and new approaches to curing cancer.
  • Regenerative Medicine
    Research how to program, or reprogram, human cells to regenerate organs and treat disease.
  • Pharmacogenomics and Genetics Use cutting-edge genetic technologies to discover, at the molecular and genetic levels, why humans have vastly different responses to drugs.
  • Drug Discovery
    Use supercomputers and chemistry to discover and develop mechanism-based drugs.
  • Neurobiology and Genetics of Addiction
    Ever wonder how genetics affect addictive behavior? Mayo has several innovative studies underway.
  • Cardiovascular Biology and Therapeutics
    Identify the molecular mechanisms and genetic defects that contribute to heart disease and develop improved therapies.

Exceptional Outcomes
Our success in training students is demonstrated by the:

  • Tremendous productivity during student training, including publications in high-impact journals
  • Excellent postdoctoral opportunities
  • Fulfilling careers, as leaders in academia and industry, that former students have pursued
  • Extra funding of a highly competitive, peer-reviewed NIH predoctoral pharmacology training grant of which peer reviewers say:

"The success of the program (MPET) is evident in the productivity of the trainees while they are in the program and the distinguished careers that they have after they have graduated. This program has numerous strengths, including a heavily funded and engaged cohort of trainers, a comprehensive didactic program, and an administration that has a demonstrated commitment to graduate education ... the program is highly effective at training these students and bringing out their best. Along these lines, the MPET is a highly cohesive program with significant evidence of collaboration and numerous events that bring faculty and students together. It appears that MPET students are trained by 'a village' ... Overall, this is an excellent training program and enthusiasm for this program is very, very high."
—Peer Review of the National Institutes of Health Predoctoral Training Grant