Publications

  1. Tischer A, Machha VR, Frontroth JP, Brehm MA, Obser T, Schneppenheim R, Mayne L, Walter Englander S, Auton M. Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping. J Mol Biol. 2017 Jul 07; 429: (14)2161-2177.
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  2. Blackburn PR, Tischer A, Zimmermann MT, Kemppainen JL, Sastry S, Knight Johnson AE, Cousin MA, Boczek NJ, Oliver G, Misra VK, Gavrilova RH, Lomberk G, Auton M, Urrutia R, Klee EW. A Novel Kleefstra Syndrome-associated Variant That Affects the Conserved TPLX Motif within the Ankyrin Repeat of EHMT1 Leads to Abnormal Protein Folding. J Biol Chem. 2017 Mar 03; 292: (9)3866-3876.
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  3. Machha VR, Tischer A, Moon-Tasson L, Auton M. The Von Willebrand Factor A1-Collagen III Interaction Is Independent of Conformation and Type 2 Von Willebrand Disease Phenotype. J Mol Biol. 2017 Jan 06; 429: (1)32-47.
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  4. Rosgen J, Auton M. Comment on "Osmolyte Effects on Monoclonal Antibody Stability and Concentration-Dependent Protein Interactions with Water and Common Osmolytes". J Phys Chem B. 2016 Nov 03; 120: (43)11331-11332.
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  5. Lea WA, O'Neil PT, Machen AJ, Naik S, Chaudhri T, McGinn-Straub W, Tischer A, Auton MT, Burns JR, Baldwin MR, Khar KR, Karanicolas J, Fisher MT. Chaperonin-Based Biolayer Interferometry To Assess the Kinetic Stability of Metastable, Aggregation-Prone Proteins. Biochemistry. 2016 Sep 6; 55 (35):4885-908 Epub 2016 Aug 19
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  6. Campbell JC, Tischer A, Machha V, Moon-Tasson L, Sankaran B, Kim C, Auton M. Data on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain. Data Brief. 2016 Jun; 7:1700-1706.
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  7. Auton M. Untangling a Structurally Resolved Protein Folding Intermediate. Biophys J. 2016 Mar 29; 110: (6)1205-6.
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  8. Tischer A, Campbell JC, Machha VR, Moon-Tasson L, Benson LM, Sankaran B, Kim C, Auton M. Mutational Constraints on Local Unfolding Inhibit the Rheological Adaptation of von Willebrand Factor. J Biol Chem. 2016 Feb 19; 291: (8)3848-59.
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  9. Blancas-Mejia LM, Horn TJ, Marin-Argany M, Auton M, Tischer A, Ramirez-Alvarado M. Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding. Biophys Chem. 2015 Dec; 207:13-20.
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  10. Zimmermann MT, Tischer A, Whitten ST, Auton M. Structural origins of misfolding propensity in the platelet adhesive von Willebrand factor A1 domain. Biophys J. 2015 Jul 21; 109: (2)398-406.
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  11. Perez RB, Tischer A, Auton M, Whitten ST. Alanine and proline content modulate global sensitivity to discrete perturbations in disordered proteins. Proteins-structure Function And Bioinformatics. 2014 Dec; 82(12):3373-84.
  12. Tischer A, Lilie H, Auton M, Lange C. Oxidative refolding of rPA in l-ArgHCl and in ionic liquids: A correlation between hydrophobicity, salt effects, and refolding yield. Biopolymers. 2014 Nov; 101: (11)1129-40.
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  13. Tischer A, Madde P, Moon-Tasson L, Auton M. Misfolding of vWF to pathologically disordered conformations impacts the severity of von Willebrand disease. Biophys J. 2014 Sep 02; 107 (5):1185-1195
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  14. Tischer A, Madde P, Blancas-Mejia LM, Auton M. A molten globule intermediate of the von Willebrand factor A1 domain firmly tethers platelets under shear flow. Proteins. 2014 May; 82: (5)867-78.
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  15. Tischer A, Pultke H, Topf A, Auton M, Lange C, Lilie H. The effects of N-ethyl-N'-methyl imidazolium chloride on the solubility, stability and aggregation of tc-rPA. FEBS J. 2014 Apr; 281(7):1738-49. Epub 2014 Feb 19.
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  16. Blancas-Mejia LM, Tischer A, Thompson JR, Tai J, Wang L, Auton M, Ramirez-Alvarado M. Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations. J Mol Biol. 2014 Jan 23; 426: (2)347-61.
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  17. Tischer A, Auton M. Urea-temperature phase diagrams capture the thermodynamics of denatured state expansion that accompany protein unfolding. Protein Sci. 2013 Sep; 22: (9)1147-60.
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  18. Tischer A, Cruz MA, Auton M. The linker between the D3 and A1 domains of vWF suppresses A1-GPIbalpha catch bonds by site-specific binding to the A1 domain. Protein Sci. 2013 Aug; 22: (8)1049-59.
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  19. Auton M, Bassett GR, Gillard BK, Pownall HJ. Free cholesterol determines reassembled high-density lipoprotein phospholipid phase structure and stability. Biochemistry. 2013 Jun 25; 52(25):4324-30. Epub 2013 Jun 14.
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  20. Auton M, Sowa KE, Behymer M, Cruz MA. N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress. J Biol Chem. 2012 Apr 27; 287(18):14579-85. Epub 2012 Mar 19.
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  21. Auton M, Rosgen J, Sinev M, Holthauzen LM, Bolen DW. Osmolyte effects on protein stability and solubility: a balancing act between backbone and side-chains. Biophys Chem. 2011 Nov; 159(1):90-9. Epub 2011 May 19.
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  22. Holthauzen LM, Auton M, Sinev M, Rosgen J. Protein stability in the presence of cosolutes. Methods Enzymol. 2011; 492:61-125.
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  23. Auton M, Zhu C, Cruz MA. The mechanism of VWF-mediated platelet GPIbalpha binding. Biophys J. 2010 Aug 9; 99(4):1192-201.
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  24. Auton M, Sowa KE, Smith SM, Sedlak E, Vijayan KV, Cruz MA. Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress. J Biol Chem. 2010 Jul 23; 285(30):22831-9. Epub 2010 May 24.
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  25. Auton M, Sedlak E, Marek J, Wu T, Zhu C, Cruz MA. Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha. Biophys J. 2009 Jul 22; 97(2):618-27.
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  26. Auton M, Bolen DW, Rosgen J. Structural thermodynamics of protein preferential solvation: osmolyte solvation of proteins, aminoacids, and peptides. Proteins. 2008 Dec; 73(4):802-13.
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  27. Auton M, Holthauzen LM, Bolen DW. Anatomy of energetic changes accompanying urea-induced protein denaturation. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15317-22. Epub 2007 Sep 18.
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  28. Auton M, Cruz MA, Moake J. Conformational stability and domain unfolding of the Von Willebrand factor A domains. J Mol Biol. 2007 Feb 23; 366(3):986-1000. Epub 2006 Oct 25.
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  29. Auton M, Bolen DW. Application of the transfer model to understand how naturally occurring osmolytes affect protein stability. Methods Enzymol. 2007; 428:397-418.
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  30. Auton M, Ferreon AC, Bolen DW. Metrics that differentiate the origins of osmolyte effects on protein stability: a test of the surface tension proposal. J Mol Biol. 2006 Sep 1; 361(5):983-92. Epub 2006 Aug 04.
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  31. Auton M, Bolen DW. Predicting the energetics of osmolyte-induced protein folding/unfolding. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15065-8. Epub 2005 Oct 07.
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  32. Auton M, Bolen DW. Additive transfer free energies of the peptide backbone unit that are independent of the model compound and the choice of concentration scale. Biochemistry. 2004 Feb 10; 43(5):1329-42.
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