Publications

  1. Takahashi R, Markovic SN, Scrable HJ. Dominant effects of Delta40p53 on p53 function and melanoma cell fate. J Invest Dermatol. 2014 Mar; 134(3):791-800. Epub 2013 Sep 13.
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  2. Takahashi R, Markovic SN, Scrable HJ. Dominant effects of delta 40p53 on p53 function and melanoma cell fate. J Invest Dermatol. 2014; 134(3):791-800.
  3. Pehar M, Ko MH, Li M, Scrable H, Puglielli L. P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion. Aging Cell. 2014; 13(3):449-56.
  4. Stevenson M, Carlisle R, Davies B, Preece C, Hammett M, Liu WL, Fisher KD, Ryan A, Scrable H, Seymour LW. Development of a positive-readout mouse model of sirna pharmacodynamics. Molecular Therapy-nucleic Acids. 2013 Nov; 2:e133.
  5. Takahashi R, Giannini C, Sarkaria JN, Schroeder M, Rogers J, Mastroeni D, Scrable H. p53 isoform profiling in glioblastoma and injured brain. Oncogene. 2013 Jun 27; 32(26):3165-74. Epub 2012 Jul 23.
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  6. Gambino V, De Michele G, Venezia O, Migliaccio P, Dall'Olio V, Bernard L, Minardi SP, Della Fazia MA, Bartoli D, Servillo G, Alcalay M, Luzi L, Giorgio M, Scrable H, Pelicci PG, Migliaccio E. Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging. Aging Cell. 2013 Jun; 12(3):435-45. Epub 2013 Mar 27
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  7. Franck D, Tracy L, Armata HL, Delaney CL, Jung DY, Ko HJ, Ong H, Kim JK, Scrable H, Sluss HK. Glucose tolerance in mice is linked to the dose of the p53 transactivation domain. Endocr Res. 2013; 38(3):139-50.
  8. Hinault C, Kawamori D, Liew CW, Maier B, Hu J, Keller SR, Mirmira RG, Scrable H, Kulkarni RN. Delta40 Isoform of p53 controls beta-cell proliferation and glucose homeostasis in mice. Diabetes. 2011 Apr; 60(4):1210-22. Epub 2011 Feb 25.
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  9. Ungewitter E, Scrable H. Delta40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs. Genes Dev. 2010 Nov 1; 24(21):2408-19.
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  10. Ungewitter E, Scrable H. Delta 40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs. Genes Dev. 2010 Nov; 24(21):2408-19.
  11. Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen MD, Kirkland JL. Fat tissue, aging, and cellular senescence. Aging Cell. 2010 Oct; 9(5):667-84. Epub 2010 Aug 15.
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  12. Li H, Costantini C, Scrable H, Weindruch R, Puglielli L. Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R. Neurobiol Aging. 2009 Dec; 30(12):2010-20. Epub 2008 Apr 02.
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  13. Scrable H, Burns-Cusato M, Medrano S. Anxiety and the aging brain: stressed out over p53? Biochim Biophys Acta. 2009 Dec; 1790(12):1587-91. Epub 2009 Oct 01.
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  14. Medrano S, Burns-Cusato M, Atienza MB, Rahimi D, Scrable H. Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53. Neurobiol Aging. 2009 Mar; 30(3):483-97. Epub 2007 Sep 11.
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  15. Ungewitter E, Scrable H. Antagonistic pleiotropy and p53. Mech Ageing Dev. 2009 Jan-Feb; 130(1-2):10-7. Epub 2008 Jul 01.
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  16. Scrable H, Medrano S, Ungewitter E. Running on empty: how p53 controls INS/IGF signaling and affects life span. Exp Gerontol. 2009 Jan-Feb; 44(1-2):93-100. Epub 2008 Jun 13.
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  17. Kipnis J, Derecki NC, Yang C, Scrable H. Immunity and cognition: what do age-related dementia, HIV-dementia and 'chemo-brain' have in common? Trends Immunol. 2008 Oct; 29(10):455-63. Epub 2008 Sep 11.
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  18. Ryan A, Scrable H. Mutant alleles of HD improve the life span of p53(-/-) mice. Mech Ageing Dev. 2008 Apr; 129(4):238-41. Epub 2007 Dec 23.
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  19. Iizuka M, Sarmento OF, Sekiya T, Scrable H, Allis CD, Smith MM. Hbo1 Links p53-dependent stress signaling to DNA replication licensing. Mol Cell Biol. 2008 Jan; 28(1):140-53. Epub 2007 Oct 22.
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  20. Sasaki T, Maier B, Koclega KD, Chruszcz M, Gluba W, Stukenberg PT, Minor W, Scrable H. Phosphorylation regulates SIRT1 function. PLoS One. 2008; 3(12):e4020. Epub 2008 Dec 24.
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  21. Ryan AB, Zeitlin SO, Scrable H. Genetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesis. Neurobiol Dis. 2006 Nov; 24(2):419-27. Epub 2006 Sep 15.
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  22. Sasaki T, Maier B, Bartke A, Scrable H. Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell. 2006 Oct; 5(5):413-22. Epub 2006 Aug 25.
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  23. Costantini C, Scrable H, Puglielli L. An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generation. EMBO J. 2006 May 3; 25(9):1997-2006. Epub 2006 Apr 13.
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  24. Sleight SB, Miranda PV, Plaskett NW, Maier B, Lysiak J, Scrable H, Herr JC, Visconti PE. Isolation and proteomic analysis of mouse sperm detergent-resistant membrane fractions: evidence for dissociation of lipid rafts during capacitation. Biol Reprod. 2005 Oct; 73(4):721-9. Epub 2005 May 25.
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  25. Medrano S, Scrable H. Maintaining appearances--the role of p53 in adult neurogenesis. Biochem Biophys Res Commun. 2005 Jun 10; 331(3):828-33.
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  26. Scrable H, Sasaki T, Maier B. DeltaNp53 or p44: priming the p53 pump. Int J Biochem Cell Biol. 2005 May; 37(5):913-9. Epub 2005 Jan 11.
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  27. Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, Sutherland A, Thorner M, Scrable H. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 2004 Feb 1; 18(3):306-19.
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  28. Ryan A, Scrable H. Visualization of the dynamics of gene expression in the living mouse. Mol Imaging. 2004 Jan; 3(1):33-42.
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  29. Cronin CA, Ryan AB, Talley EM, Scrable H. Tyrosinase expression during neuroblast divisions affects later pathfinding by retinal ganglion cells. J Neurosci. 2003 Dec 17; 23(37):11692-7.
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  30. Maier B, Medrano S, Sleight SB, Visconti PE, Scrable H. Developmental association of the synaptic activity-regulated protein arc with the mouse acrosomal organelle and the sperm tail. Biol Reprod. 2003 Jan; 68(1):67-76.
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  31. Scrable H. Say when: reversible control of gene expression in the mouse by lac. Semin Cell Dev Biol. 2002 Apr; 13(2):109-19.
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  32. Cronin CA, Gluba W, Scrable H. The lac operator-repressor system is functional in the mouse. Genes Dev. 2001 Jun 15; 15(12):1506-17.
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  33. Scrable H, Stambrook PJ. A genetic program for deletion of foreign DNA from the mammalian genome. Mutat Res. 1999 Oct 19; 429(2):225-37.
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  34. Scrable H, Stambrook PJ. Activation of the lac repressor in the transgenic mouse. Genetics. 1997 Sep; 147(1):297-304.
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  35. Lee KS, Schottler F, Collins JL, Lanzino G, Couture D, Rao A, Hiramatsu K, Goto Y, Hong SC, Caner H, Yamamoto H, Chen ZF, Bertram E, Berr S, Omary R, Scrable H, Jackson T, Goble J, Eisenman L. A genetic animal model of human neocortical heterotopia associated with seizures. J Neurosci. 1997 Aug 15; 17(16):6236-42.
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  36. Henry I, van Heyningen V, Puech A, Scrable H, Augereau P, Boehm T, Rabbitts T, Mannens M, Rochefort H, Jones C, et al. Reassessment of breakpoints in chromosome 11p15. Cytogenet Cell Genet. 1993; 62(1):52-3.
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  37. Loh WE Jr, Scrable HJ, Livanos E, Arboleda MJ, Cavenee WK, Oshimura M, Weissman BE. Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A. 1992 Mar 1; 89(5):1755-9.
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  38. Daston MM, Scrable H, Nordlund M, Sturbaum AK, Nissen LM, Ratner N. The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes. Neuron. 1992 Mar; 8(3):415-28.
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  39. Liu HS, Scrable H, Villaret DB, Lieberman MA, Stambrook PJ. Control of Ha-ras-mediated mammalian cell transformation by Escherichia coli regulatory elements. Cancer Res. 1992 Feb 15; 52(4):983-9.
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  40. Tonin PN, Scrable H, Shimada H, Cavenee WK. Muscle-specific gene expression in rhabdomyosarcomas and stages of human fetal skeletal muscle development. Cancer Res. 1991 Oct 1; 51(19):5100-6.
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  41. Cavenee WK, Scrable HJ, James CD. Molecular genetics of human cancer predisposition and progression. Mutat Res. 1991 Apr; 247(2):199-202.
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  42. Mulligan LM, Matlashewski GJ, Scrable HJ, Cavenee WK. Mechanisms of p53 loss in human sarcomas. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5863-7.
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  43. Scrable HJ, Johnson DK, Rinchik EM, Cavenee WK. Rhabdomyosarcoma-associated locus and MYOD1 are syntenic but separate loci on the short arm of human chromosome 11. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2182-6.
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  44. Scrable HJ, Sapienza C, Cavenee WK. Genetic and epigenetic losses of heterozygosity in cancer predisposition and progression. Adv Cancer Res. 1990; 54:25-62.
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  45. Scrable H, Cavenee W, Ghavimi F, Lovell M, Morgan K, Sapienza C. A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting. Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7480-4.
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  46. Scrable H, Witte D, Shimada H, Seemayer T, Sheng WW, Soukup S, Koufos A, Houghton P, Lampkin B, Cavenee W. Molecular differential pathology of rhabdomyosarcoma. Genes Chromosomes Cancer. 1989 Sep; 1(1):23-35.
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  47. Cavenee WK, Hansen MF, Scrable HJ, James CD. Loss of genetic information in cancer. of Tumor Suppression Ciba Foundation Symposium 14279-88 1989; IN:Genetic Analysis.
  48. Scrable HJ, Witte DP, Lampkin BC, Cavenee WK. Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping. Nature. 1987 Oct 15-21; 329(6140):645-7.
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