Publications

  1. Renfro LA, Sargent DJ. Statistical controversies in clinical research: basket trials, umbrella trials, and other master protocols: a review and examples. Ann Oncol 2016 Oct 11 [Epub ahead of print]
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  2. Lynn PB, Renfro LA, Carrero XW, Shi Q, Strombom PL, Chow O, Garcia-Aguilar J. Anorectal Function and Quality of Life in Patients with Early Stage Rectal Cancer Treated with Chemoradiation and Local Excision Dis Colon Rectum (in press).2016;
  3. Renfro LA, Zhang N, Lopatin M, Chao C, Alberts SR. Prospective Evaluation of a 12-Gene Assay on Patient Treatment Decisions and Physician Confidence in Mismatch Repair Proficient Stage IIA Colon Cancer. Clin Colorectal Cancer 2016 Aug 9 Epub 2016 Aug 09
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  4. Renfro LA, Shi Q, Sargent DJ. Surrogate Endpoints in Soft Tissue Sarcoma: Methodological Challenges J Clin Oncol (in press).2016;
  5. Renfro LA, Shi Q, Sargent DJ. The Adjuvant Colon Cancer End Points (ACCENT) Collaborative Group: Research History and Updated Findings Based on Pooled Patient Data from 27 Clinical Trials in Colon Cancer Chin Clin Oncol (in press).2016;
  6. Adjuvant Colon Cancer Endpoints (ACCENT) Group, Papamichael D, Renfro LA, Matthaiou C, Yothers G, Saltz L, Guthrie KA, Van Cutsem E, Schmoll HJ, Labianca R, Andre T, O'Connell M, Alberts SR, Haller DG, Kountourakis P, Sargent DJ. Validity of Adjuvant! Online in older patients with stage III colon cancer based on 2967 patients from the ACCENT database. J Geriatr Oncol 2016 Jul 25 Epub 2016 July 25
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  7. Cheung WY, Renfro LA, Kerr D, de Gramont A, Saltz LB, Grothey A, Alberts SR, Andre T, Guthrie KA, Labianca R, Francini G, Seitz JF, O'Callaghan C, Twelves C, Van Cutsem E, Haller DG, Yothers G, Sargent DJ. Determinants of Early Mortality Among 37,568 Patients With Colon Cancer Who Participated in 25 Clinical Trials From the Adjuvant Colon Cancer Endpoints Database. J Clin Oncol 2016 Apr 10; 34 (11):1182-9 Epub 2016 Feb 08
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  8. Renfro LA, An MW, Mandrekar SJ. Precision oncology: A new era of cancer clinical trials. Cancer Lett 2016 Mar 14 [Epub ahead of print]
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  9. Shah MA, Renfro LA, Allegra CJ, Andre T, de Gramont A, Schmoll HJ, Haller DG, Alberts SR, Yothers G, Sargent DJ. Impact of Patient Factors on Recurrence Risk and Time Dependency of Oxaliplatin Benefit in Patients With Colon Cancer: Analysis From Modern-Era Adjuvant Studies in the Adjuvant Colon Cancer End Points (ACCENT) Database. J Clin Oncol 2016 Mar 10; 34 (8):843-53 Epub 2016 Jan 25
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  10. Renfro LA, Mallick H, An MW, Sargent DJ, Mandrekar SJ. Clinical trial designs incorporating predictive biomarkers. Cancer Treat Rev 2016 Feb; 43:74-82 Epub 2016 Jan 05
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  11. Renfro LA, Loupakis F, Adams RA, Seymour MT, Heinemann V, Schmoll HJ, Douillard JY, Hurwitz H, Fuchs CS, Diaz-Rubio E, Porschen R, Tournigand C, Chibaudel B, Falcone A, Tebbutt NC, Punt CJ, Hecht JR, Bokemeyer C, Van Cutsem E, Goldberg RM, Saltz LB, de Gramont A, Sargent DJ, Lenz HJ. Gramont A, Sargent DJ, Lenz HJ. Body Mass Index Is Prognostic in Metastatic Colorectal Cancer: Pooled Analysis of Patients From First-Line Clinical Trials in the ARCAD Database. J Clin Oncol 2016 Jan 10; 34 (2):144-50 Epub 2015 Oct 26
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  12. Shi Q, Sargent DJ, Renfro LA. Findings from the Adjuvant Colon Cancer End Points (ACCENT) collaborative group: the power of pooled individual patient data from multiple clinical trials Current Colorectal Cancer Reports 2016; 12 (5):251-9
  13. Garcia-Aguilar J, Renfro LA, Chow OS, Shi Q, Carrero XW, Lynn PB, Thomas CR Jr, Chan E, Cataldo PA, Marcet JE, Medich DS, Johnson CS, Oommen SC, Wolff BG, Pigazzi A, McNevin SM, Pons RK, Bleday R. Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial. Lancet Oncol 2015 Nov; 16 (15):1537-46 Epub 2015 Oct 22
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  14. Foster NR, Renfro LA, Schild SE, Redman MW, Wang XF, Dahlberg SE, Ding K, Bradbury PA, Ramalingam SS, Gandara DR, Shibata T, Saijo N, Vokes EE, Adjei AA, Mandrekar SJ. Multitrial Evaluation of Progression-Free Survival as a Surrogate End Point for Overall Survival in First-Line Extensive-Stage Small-Cell Lung Cancer. J Thorac Oncol 2015 Jul; 10 (7):1099-106
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  15. Adjuvant Colon Cancer Endpoints (ACCENT) Group//Adjuvant Colon Cancer Endpoints ACCENT Group, Renfro LA, Grothey A, Kerr D, Haller DG, Andre T, Van Cutsem E, Saltz L, Labianca R, Loprinzi CL, Alberts SR, Schmoll H, Twelves C, Yothers G, Sargent DJ. Survival following early-stage colon cancer: an ACCENT-based comparison of patients versus a matched international general populationdagger. Ann Oncol 2015 May; 26 (5):950-8 Epub 2015 Feb 19
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  16. Renfro LA, Shang H, Sargent DJ. Impact of Copula Directional Specification on Multi-Trial Evaluation of Surrogate End Points. J Biopharm Stat 2015; 25 (4):857-77
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  17. Renfro LA, Mandrekar SJ. Targeted therapies in oncology: perspectives on trial designs and practical challenges. Clinical Investigation. 2015; 5(2):117-119.
  18. Alberts SR, Yu TM, Behrens RJ, Renfro LA, Srivastava G, Soori GS, Dakhil SR, Mowat RB, Kuebler JP, Kim GP, Mazurczak MA, Hornberger J. Comparative economics of a 12-gene assay for predicting risk of recurrence in stage II colon cancer. Pharmacoeconomics 2014 Dec; 32 (12):1231-43
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  19. Adjuvant Colon Cancer Endpoints (ACCENT) Group, Renfro LA, Grothey A, Xue Y, Saltz LB, Andre T, Twelves C, Labianca R, Allegra CJ, Alberts SR, Loprinzi CL, Yothers G, Sargent DJ. ACCENT-based web calculators to predict recurrence and overall survival in stage III colon cancer. J Natl Cancer Inst 2014 Dec; 106 (12) Epub 2014 Oct 29
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  20. Renfro LA, Grothey AM, Paul J, Floriani I, Bonnetain F, Niedzwiecki D, Yamanaka T, Souglakos I, Yothers G, Sargent DJ. Projecting Event-Based Analysis Dates in Clinical Trials: An Illustration Based on the International Duration Evaluation of Adjuvant Chemotherapy (IDEA) Collaboration. Projecting analysis dates for the IDEA collaboration. Forum Clin Oncol 2014 Dec; 5 (2):1-7 Epub 2014 Dec 10
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  21. Renfro LA, Shi Q, Xue Y, Li J, Shang H, Sargent DJ. Center-Within-Trial Versus Trial-Level Evaluation of Surrogate Endpoints. Comput Stat Data Anal 2014 Oct 1; 78:1-20
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  22. Lieu CH, Renfro LA, de Gramont A, Meyers JP, Maughan TS, Seymour MT, Saltz L, Goldberg RM, Sargent DJ, Eckhardt SG, Eng C, Aide et Recherche en Cancerologie Digestive Foundation. Association of age with survival in patients with metastatic colorectal cancer: analysis from the ARCAD Clinical Trials Program. J Clin Oncol. 2014 Sep 20; 32(27):2975-84.
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  23. Alliance for Clinical Trials in Oncology, Shiovitz S, Bertagnolli MM, Renfro LA, Nam E, Foster NR, Dzieciatkowski S, Luo Y, Lao VV, Monnat RJ Jr, Emond MJ, Maizels N, Niedzwiecki D, Goldberg RM, Saltz LB, Venook A, Warren RS, Grady WM. CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer. Gastroenterology 2014 Sep; 147 (3):637-45 Epub 2014 May 21
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  24. Srivastava G, Renfro LA, Behrens RJ, Lopatin M, Chao C, Soori GS, Dakhil SR, Mowat RB, Kuebler JP, Kim G, Mazurczak M, Lee M, Alberts SR. Prospective multicenter study of the impact of oncotype DX colon cancer assay results on treatment recommendations in stage II colon cancer patients. Oncologist 2014 May; 19 (5):492-7 Epub 2014 Apr 07
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  25. Renfro LA, Coughlin CM, Grothey AM, Sargent DJ. Adaptive randomized phase II design for biomarker threshold selection and independent evaluation. Chin Clin Oncol 2014 Mar 01; 3 (1)
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  26. Sanoff HK, Renfro LA, Poonnen P, Ambadwar P, Sargent DJ, Goldberg RM, McLeod H. Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer. PLoS One 2014; 9 (4):e94727 Epub 2014 Apr 11
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  27. Ryan C, Kelleher J, Fagan MF, Rogers S, Collins P, Barker JNWN, Allen M, Hagan R, Renfro L, Kirby B. Genetic markers of treatment response to tumour necrosis factor-alpha inhibitors in the treatment of psoriasis. Clin Exp Dermatol. 2014; 39(4):519-24.
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  28. Pavelitz T, Renfro L, Foster NR, Caracol A, Welsch P, Lao VV, Grady WB, Niedzwiecki D, Saltz LB, Bertagnolli MM, Goldberg RM, Rabinovitch PS, Emond M, Monnat RJ Jr, Maizels N. MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial. PLoS One 2014; 9 (10):e108483 Epub 2014 Oct 13
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  29. Renfro LA, Shi Q, Sargent DJ. Mining the ACCENT database: a review and update. Chin Clin Oncol 2013 Jun; 2 (2):18
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  30. Shafi S, Renfro LA, Barnes S, Rayan N, Gentilello LM, Fleming N, Ballard D. Chronic consequences of acute injuries: worse survival after discharge. J Trauma Acute Care Surg. 2012 Sep; 73(3):699-703.
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  31. Renfro LA, Shi Q, Sargent DJ, Carlin BP. Bayesian adjusted R2 for the meta-analytic evaluation of surrogate time-to-event endpoints in clinical trials. Stat Med. 2012 Apr 13; 31(8):743-61. Epub 2011 Dec 09.
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  32. Renfro LA, Carlin BP, Sargent DJ. Bayesian adaptive trial design for a newly validated surrogate endpoint. Biometrics 2012 Mar; 68 (1):258-67 Epub 2011 Aug 12
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  33. Renfro LA, Sargent DJ. Multi-trial databases for improved learning in oncology. Treatment Strategies in Oncology (Ebook) http://viewerzmagscom/publication/e049b37c#/e049b37c/1. 2012; 3(1):59-62.
  34. Shi Q, Renfro LA, Bot BM, Burzykowski T, Buyse M, Sargent DJ. Comparative assessment of trial-level surrogacy measures for candidate time-to-event surrogate endpoints in clinical trials. Computational Statistics and Data Analysis. 2011; 55(9):2748-57.
  35. Ryan C, Renfro L, Collins P, Kirby B, Rogers S. Clinical and genetic predictors of response to narrowband ultraviolet B for the treatment of chronic plaque psoriasis. Br J Dermatol. 2010 Nov; 163(5):1056-63.
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  36. Renfro LA, Hamner MS. Predicting undergraduate re-enrollment: a Bayesian approach. The Pentagon (Kappa Mu Epsilon National Mathematics Honor Society). 2006; 62(2):7-20.