Publications

  1. Brierley SM, Linden DR. Neuroplasticity and dysfunction after gastrointestinal inflammation. Nat Rev Gastroenterol Hepatol. 2014 Oct; 11(10):611-27. Epub 2014 Jul 08.
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  2. Sha L, Linden DR, Farrugia G, Szurszewski JH. Effect of endogenous hydrogen sulfide on the transwall gradient of the mouse colon circular smooth muscle. J Physiol. 2014 Mar 1; 592(Pt 5):1077-89. Epub 2013 Dec 23
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  3. Linden DR. Hydrogen sulfide signaling in the gastrointestinal tract. Antioxid Redox Signal. 2014 Feb 10; 20(5):818-30. Epub 2013 May 19.
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  4. Grover M, Camilleri M, Smith K, Linden DR, Farrugia G. On the fiftieth anniversary. Postinfectious irritable bowel syndrome: mechanisms related to pathogens. Neurogastroenterol Motil. 2014 Feb; 26(2):156-67.
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  5. Ferreira PE, Lopes CR, Alves AM, Alves EP, Linden DR, Zanoni JN, Buttow NC. Diabetic neuropathy: an evaluation of the use of quercetin in the cecum of rats. World J Gastroenterol. 2013 Oct 14; 19(38):6416-26.
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  6. Sha L, Linden DR, Farrugia G, Szurszewski JH. Hydrogen sulfide selectively potentiates central preganglionic fast nicotinic synaptic input in mouse superior mesenteric ganglion. J Neurosci. 2013 Jul 31; 33(31):12638-46.
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  7. Linden DR. Enhanced excitability of guinea pig ileum myenteric AH neurons during and following recovery from chemical colitis. Neurosci Lett. 2013 Jun 17; 545:91-5. Epub 2013 Apr 28.
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  8. Creedon CT, Verhulst PJ, Choi KM, Mason JE, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G. Assessment of gastric emptying in non-obese diabetic mice using a [13C]-octanoic acid breath test. J Vis Exp. 2013; (73):e50301. Epub 2013 Mar 23.
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  9. Linden DR. Colitis is associated with a loss of intestinofugal neurons. Am J Physiol Gastrointest Liver Physiol. 2012 Nov 15; 303(10):G1096-104. Epub 2012 Sep 20.
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  10. Linden DR. Enhanced excitability of guinea pig inferior mesenteric ganglion neurons during and following recovery from chemical colitis. Am J Physiol Gastrointest Liver Physiol. 2012 Nov 1; 303(9):G1067-75. Epub 2012 Sep 06.
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  11. Kasparek MS, Linden DR, Farrugia G, Sarr MG. Hydrogen sulfide modulates contractile function in rat jejunum. J Surg Res. 2012 Jun 15; 175(2):234-42. Epub 2011 Apr 22.
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  12. Linden DR, Furne J, Stoltz GJ, Abdel-Rehim MS, Levitt MD, Szurszewski JH. Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS. Br J Pharmacol. 2012 Apr; 165(7):2178-90.
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  13. Asuzu DT, Hayashi Y, Izbeki F, Popko LN, Young DL, Bardsley MR, Lorincz A, Kuro-O M, Linden DR, Farrugia G, Ordog T. Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging. Neurogastroenterol Motil. 2011 Jul; 23(7):e309-23. Epub 2011 May 24.
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  14. Strege PR, Bernard CE, Kraichely RE, Mazzone A, Sha L, Beyder A, Gibbons SJ, Linden DR, Kendrick ML, Sarr MG, Szurszewski JH, Farrugia G. Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300(6):G1105-14. Epub 2011 Mar 10.
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  15. Mazzone A, Bernard CE, Strege PR, Beyder A, Galietta LJ, Pasricha PJ, Rae JL, Parkman HP, Linden DR, Szurszewski JH, Ordog T, Gibbons SJ, Farrugia G. Altered expression of Ano1 variants in human diabetic gastroparesis. J Biol Chem. 2011 Apr 15; 286(15):13393-403. Epub 2011 Feb 24.
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  16. Nagao M, Linden DR, Duenes JA, Sarr MG. Mechanisms of action of the gasotransmitter hydrogen sulfide in modulating contractile activity of longitudinal muscle of rat ileum. J Gastrointest Surg. 2011 Jan; 15(1):12-22. Epub 2010 Nov 17.
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  17. Sha L, Farrugia G, Linden DR, Szurszewski JH. The transwall gradient across the mouse colonic circular muscle layer is carbon monoxide dependent. FASEB J. 2010 Oct; 24(10):3840-9. Epub 2010 Jun 11.
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  18. Izbeki F, Asuzu DT, Lorincz A, Bardsley MR, Popko LN, Choi KM, Young DL, Hayashi Y, Linden DR, Kuro-o M, Farrugia G, Ordog T. Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice. J Physiol. 2010 Aug 15; 588(Pt 16):3101-17. Epub 2010 Jun 25.
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  19. Choi KM, Kashyap PC, Dutta N, Stoltz GJ, Ordog T, Shea Donohue T, Bauer AJ, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G. CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice. Gastroenterology. 2010 Jun; 138(7):2399-409, 2409.e1. Epub 2010 Feb 20.
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  20. Kashyap PC, Choi KM, Dutta N, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G. Carbon monoxide reverses diabetic gastroparesis in NOD mice. Am J Physiol Gastrointest Liver Physiol. 2010 Jun; 298(6):G1013-9. Epub 2010 Apr 08.
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  21. Linden DR, Levitt MD, Farrugia G, Szurszewski JH. Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function. Antioxid Redox Signal. 2010 May 1; 12(9):1135-46.
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  22. Bharucha AE, Linden DR. Linaclotide - a secretagogue and antihyperalgesic agent - what next? Neurogastroenterol Motil. 2010 Mar; 22(3):227-31.
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  23. Bertrand PP, Linden DR. Getting a handle on cholera and the circuits controlling intestinal motility. Front Neurosci. 2010; 4:197. Epub 2010 Nov 25.
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  24. Hughes PA, Brierley SM, Martin CM, Brookes SJ, Linden DR, Blackshaw LA. Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses. Gut. 2009 Oct; 58(10):1333-41. Epub 2009 Mar 25.
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  25. Bernard CE, Gibbons SJ, Gomez-Pinilla PJ, Lurken MS, Schmalz PF, Roeder JL, Linden D, Cima RR, Dozois EJ, Larson DW, Camilleri M, Zinsmeister AR, Pozo MJ, Hicks GA, Farrugia G. Effect of age on the enteric nervous system of the human colon. Neurogastroenterol Motil. 2009 Jul; 21(7):746-e46. Epub 2009 Feb 08.
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  26. Linden DR, White SL, Brooks EM, Mawe GM. Novel promoter and alternate transcription start site of the human serotonin reuptake transporter in intestinal mucosa. Neurogastroenterol Motil. 2009 May; 21(5):534-41, e10-1. Epub 2009 Feb 13.
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  27. Linden DR, Sha L, Mazzone A, Stoltz GJ, Bernard CE, Furne JK, Levitt MD, Farrugia G, Szurszewski JH. Production of the gaseous signal molecule hydrogen sulfide in mouse tissues. J Neurochem. 2008 Aug; 106(4):1577-85. Epub 2008 May 29.
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  28. Kasparek MS, Linden DR, Kreis ME, Sarr MG. Gasotransmitters in the gastrointestinal tract. Surgery. 2008 Apr; 143(4):455-9. Epub 2008 Jan 30.
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  29. Krauter EM, Strong DS, Brooks EM, Linden DR, Sharkey KA, Mawe GM. Changes in colonic motility and the electrophysiological properties of myenteric neurons persist following recovery from trinitrobenzene sulfonic acid colitis in the guinea pig. Neurogastroenterol Motil. 2007 Dec; 19(12):990-1000. Epub 2007 Aug 17.
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  30. Krauter EM, Linden DR, Sharkey KA, Mawe GM. Synaptic plasticity in myenteric neurons of the guinea-pig distal colon: presynaptic mechanisms of inflammation-induced synaptic facilitation. J Physiol. 2007 Jun 1; 581(Pt 2):787-800. Epub 2007 Mar 15.
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  31. Lomax AE, Linden DR, Mawe GM, Sharkey KA. Effects of gastrointestinal inflammation on enteroendocrine cells and enteric neural reflex circuits. Auton Neurosci. 2006 Jun 30; 126-127:250-7. Epub 2006 Apr 17.
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  32. Linden DR, Couvrette JM, Ciolino A, McQuoid C, Blaszyk H, Sharkey KA, Mawe GM. Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon. Neurogastroenterol Motil. 2005 Oct; 17(5):751-60.
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  33. Linden DR, Foley KF, McQuoid C, Simpson J, Sharkey KA, Mawe GM. Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis. Neurogastoenerol Motil. 2005 Aug; 17(4):565-74.
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  34. Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM, Moses PL. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology. 2004 Jun; 126(7):1657-64.
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  35. Linden DR, Sharkey KA, Ho W, Mawe GM. Cyclooxygenase-2 contributes to dysmotility and enhanced excitability of myenteric AH neurons in the inflamed guinea pig distal colon. J Physiol. 2004; 557:191-205.
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  36. O'Hara JR, Ho W, Linden DR, Mawe GM Sharkey KA. Enteroendocrine cells and serotonin availability are altered in the mucosa of guinea pigs with TNBS ileitis. Am J Physiol Gastrointest Liver Physiol. 2004; 287:G998-G1007.
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  37. Linden DR, Sharkey KA, Mawe GM. Enhanced neuronal excitability in the myenteric plexus of the inflamed guinea pig distal colon. J Physiol. 2003; 547:589-601.
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  38. Linden DR. Colitis: It's not just for the colon anymore. Brit J Pharmacol. 2003; 139:185-6.
  39. Linden DR, Chen JX, Gershon MD, Sharkey KA, Mawe GM. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2003; 285:G207-16.
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  40. Linden DR, El-Fakahany EE. Microglial derived nitric oxide decreases serotonin content in rat basophilic leukemia (RBL-2H3) cells. Eur J Clin Pharmacol. 2002; 436:53-6.
  41. Linden DR, El-Fakahany EE. Arachidonic acid inhibition of muscarinic receptor-mediated nitric oxide production occurs at the level of calcium mobilization in Chinese hamster ovary cells. Neurochem Res. 2002; 27:441-9.
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  42. Linden DR, Manning BP, Bunnett NW, Mawe GM. Agonists of proteinase activated receptor 2 (PAR2) excite guinea pig ileal myenteric neurons. Eur J Clin Pharmacol. 2001; 431:311-4.
  43. Linden DR, Chell MJ, El-Fakahany EE, Seybold VS. Neurokinin3 receptors couple to the activation of neuronal nitric oxide synthase in stably transfected Chinese hamster ovary cells. J Pharmacol Exp Ther. 2000; 293:559-68.
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  44. Linden DR, Reutter MA, McCarson KE, Seybold VS. Time-dependent changes in neurokinin3 receptors and tachykinins during adjuvant-induced peripheral inflammation. Neuroscience. 2000; 98:801-11.
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  45. Linden DR, Jia YP, Seybold VS. Spinal neurokinin3 receptors facilitate the nociceptive flexor reflex via a pathway involving nitric oxide. Pain. 1999; 80:301-8.
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  46. Linden DR, Seybold VS. Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide. Pain. 1999; 80:309-17.
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  47. Jia YP, Linden DR, Serie JR, Seybold VS. Nociceptin/orphanin FQ binding increases in superficial laminae of the rat spinal cord during persistent peripheral inflammation. Neurosci Lett. 1998; 250:21-4.
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