Publications

  1. Tilahun AY, Chowdhary VR, David CS, Rajagopalan G. Systemic Inflammatory Response Elicited by Superantigen Destabilizes T Regulatory Cells, Rendering Them Ineffective during Toxic Shock Syndrome. J Immunol. 2014 Sep 15; 193(6):2919-30. Epub 2014 Aug 04.
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  2. Chung JW, Karau MJ, Greenwood-Quaintance KE, Ballard AD, Tilahun A, Khaleghi SR, David CS, Patel R, Rajagopalan G. Superantigen profiling of Staphylococcus aureus infective endocarditis isolates. Diagn Microbiol Infect Dis. 2014 Jun; 79(2):119-24. Epub 2014 Mar 17.
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  3. Tilahun AY, Karau M, Ballard A, Gunaratna MP, Thapa A, David CS, Patel R, Rajagopalan G. The impact of Staphylococcus aureus-associated molecular patterns on staphylococcal superantigen-induced toxic shock syndrome and pneumonia. Mediators Inflamm. 2014; 2014:468285. Epub 2014 Jun 12.
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  4. Marietta EV, Gomez AM, Yeoman C, Tilahun AY, Clark CR, Luckey DH, Murray JA, White BA, Kudva YC, Rajagopalan G. Low incidence of spontaneous type 1 diabetes in non-obese diabetic mice raised on gluten-free diets is associated with changes in the intestinal microbiome. PLoS One. 2013; 8(11):e78687. Epub 2013 Nov 13.
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  5. Karau MJ, Tilahun AY, Schmidt SM, Clark CR, Patel R, Rajagopalan G. Linezolid is superior to vancomycin in experimental pneumonia caused by Superantigen-Producing staphylococcus aureus in HLA class II transgenic mice. Antimicrob Agents Chemother. 2012 Oct; 56(10):5401-5. Epub 2012 Jul 30.
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  6. Chowdhary VR, Tilahun AY, Clark CR, Grande JP, Rajagopalan G. Chronic exposure to staphylococcal superantigen elicits a systemic inflammatory disease mimicking lupus. J Immunol. 2012 Aug 15; 189(4):2054-62. Epub 2012 Jul 13.
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  7. Tilahun AY, Karau MJ, Clark CR, Patel R, Rajagopalan G. The impact of tacrolimus on the immunopathogenesis of staphylococcal enterotoxin-induced systemic inflammatory response syndrome and pneumonia. Microbes Infect. 2012 Jun; 14(6):528-36. Epub 2012 Jan 10.
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  8. Deshmukh US, Sim DL, Dai C, Kannapell CJ, Gaskin F, Rajagopalan G, David CS, Fu SM. HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD. J Autoimmun. 2011 Nov; 37(3):254-62. Epub 2011 Aug 24.
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  9. Rajagopalan G, Tilahun AY, Iijima K, David CS, Kita H, Juhn YJ. HLA-DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation. Tissue Antigens. 2011 Jun; 77(6):589-92. Epub 2011 Mar 30.
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  10. Tilahun AY, Marietta EV, Wu TT, Patel R, David CS, Rajagopalan G. Human leukocyte antigen class II transgenic mouse model unmasks the significant extrahepatic pathology in toxic shock syndrome. Am J Pathol. 2011 Jun; 178(6):2760-73.
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  11. Tilahun AY, Holz M, Wu TT, David CS, Rajagopalan G. Interferon gamma-dependent intestinal pathology contributes to the lethality in bacterial superantigen-induced toxic shock syndrome. PLoS One. 2011; 6(2):e16764. Epub 2011 Feb 03.
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  12. Tilahun ME, Kwan A, Natarajan K, Quinn M, Tilahun AY, Xie C, Margulies DH, Osborne BA, Goldsby RA, Rajagopalan G. Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB. PLoS One. 2011; 6(11):e27203. Epub 2011 Nov 15.
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  13. Tilahun AY, Theuer JE, Patel R, David CS, Rajagopalan G. Detrimental effect of the proteasome inhibitor, bortezomib in bacterial superantigen- and lipopolysaccharide-induced systemic inflammation. Mol Ther. 2010 Jun; 18(6):1143-54. Epub 2010 Apr 06.
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  14. Tilahun ME, Rajagopalan G, Shah-Mahoney N, Lawlor RG, Tilahun AY, Xie C, Natarajan K, Margulies DH, Ratner DI, Osborne BA, Goldsby RA. Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies. Infect Immun. 2010 Jun; 78(6):2801-11. Epub 2010 Mar 22.
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  15. Rajagopalan G, Tilahun AY, Asmann YW, David CS. Early gene expression changes induced by the bacterial superantigen staphylococcal enterotoxin B and its modulation by a proteasome inhibitor. Physiol Genomics. 2009 May 13; 37(3):279-93. Epub 2009 Mar 31.
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  16. Rajagopalan G, Asmann YW, Lytle AK, Tilahun AY, Theuer JE, Smart MK, Patel R, David CS. Cyclooxygenase 2 pathway and its therapeutic inhibition in superantigen-induced toxic shock. Shock. 2008 Dec; 30(6):721-8.
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  17. Rajagopalan G, Polich G, Sen MM, Singh M, Epstein BE, Lytle AK, Rouse MS, Patel R, David CS. Evaluating the role of HLA-DQ polymorphisms on immune response to bacterial superantigens using transgenic mice. Tissue Antigens. 2008 Feb; 71(2):135-45. Epub 2007 Dec 13.
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  18. Mangalam AK, Rajagopalan G, Taneja V, David CS. HLA class II transgenic mice mimic human inflammatory diseases. Adv Immunol. 2008; 97:65-147.
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  19. Rajagopalan G, Mangalam AK, Sen MM, Kudva YC, David CS. Distinct local immunogenic stimuli dictate differential requirements for CD4+ and CD8+ T cell subsets in the pathogenesis of spontaneous autoimmune diabetes. Autoimmunity. 2007 Nov; 40(7):489-96.
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  20. Rajagopalan G, Krishnan C. Alpha-amylase production from catabolite derepressed Bacillus subtilis KCC103 utilizing sugarcane bagasse hydrolysate. Bioresour Technol. 2007 Jul 17; 99(8):3044-50 Epub 2008 May.
  21. Tracz MJ, Juncos JP, Grande JP, Croatt AJ, Ackerman AW, Rajagopalan G, Knutson KL, Badley AD, Griffin MD, Alam J, Nath KA. Renal hemodynamic, inflammatory, and apoptotic responses to lipopolysaccharide in HO-1-/- mice. Am J Pathol. 2007 Jun; 170(6):1820-30.
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  22. Rajagopalan G, Mangalam AK, Sen MM, Cheng S, Kudva YC, David CS. Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of Langerhans. Autoimmunity. 2007 May; 40(3):169-79.
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  23. Rajagopalan G, Smart MK, Murali N, Patel R, David CS. Acute systemic immune activation following vaginal exposure to staphylococcal enterotoxin B--implications for menstrual shock. J Reprod Immunol. 2007 Feb; 73(1):51-9. Epub 2006 Oct 27.
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  24. Rajagopalan G, Smart MK, Patel R, David CS. Acute systemic immune activation following conjunctival exposure to staphylococcal enterotoxin B. Infect Immun. 2006 Oct; 74(10):6016-9.
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  25. Nagarajan DR, Rajagopalan G, Krishnan C. Purification and characterization of a maltooligosaccharide-forming alpha-amylase from a new Bacillus subtilis KCC103. Appl Microbiol Biotechnol. 2006 Jul 19; 73(3):591-7 Epub 2006 Dec.
  26. Rajagopalan G, Sen MM, Singh M, Murali NS, Nath KA, Iijima K, Kita H, Leontovich AA, Gopinathan U, Patel R, David CS. Intranasal exposure to staphylococcal enterotoxin B elicits an acute systemic inflammatory response. Shock. 2006 Jun; 25(6):647-56.
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  27. Rajagopalan G, Kudva YC, Sen MM, Marietta EV, Murali N, Nath K, Moore J, David CS. IL-10-deficiency unmasks unique immune system defects and reveals differential regulation of organ-specific autoimmunity in non-obese diabetic mice. Cytokine. 2006 Apr; 34(1-2):85-95.
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  28. Rajagopalan G, Iijima K, Singh M, Kita H, Patel R, David CS. Intranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice. Infect Immun. 2006 Feb; 74(2):1284-96.
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  29. Rajagopalan G, Singh M, Sen MM, Murali NS, Nath KA, David CS. Endogenous superantigens shape response to exogenous superantigens. Clin Diagn Lab Immunol. 2005 Sep; 12(9):1119-22.
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  30. Rajagopalan G, Sen MM, David CS. In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonists. Infect Immun. 2004 Nov; 72(11):6733-7.
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  31. Rajagopalan G, Kudva YC, Chen L, Wen L, David CS. Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans. Int Immunol. 2003 Sep; 15(9):1035-44.
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  32. Rajagopalan G, Smart MK, Cheng S, Krco CJ, Johnson KL, David CS. Expression and function of HLA-DR3 and DQ8 in transgenic mice lacking functional H2-M. Tissue Antigens. 2003 Aug; 62(2):149-61.
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  33. Haritha S, Rajagopalan G. Follicular growth, endometrial thickness, and serum estradiol levels in spontaneous and clomiphene citrate-induced cycles. Int J Gynaecol Obstet. 2003 Jun; 81(3):287-92.
  34. Rajagopalan G, Kudva YC, Flavell RA, David CS. Accelerated diabetes in rat insulin promoter-tumor necrosis factor-alpha transgenic nonobese diabetic mice lacking major histocompatibility class II molecules. Diabetes. 2003 Feb; 52(2):342-7.
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  35. Kudva YC, Rajagopalan G, Raju R, Abraham RS, Smart M, Hanson J, David CS. Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II. Hum Immunol. 2002 Nov; 63(11):987-99.
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  36. Rajagopalan G, Smart MK, Krco CJ, David CS. Expression and function of transgenic HLA-DQ molecules and lymphocyte development in mice lacking invariant chain. J Immunol. 2002 Aug 15; 169(4):1774-83.
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  37. Rajagopalan G, Smart MK, Marietta EV, David CS. Staphylococcal enterotoxin B-induced activation and concomitant resistance to cell death in CD28-deficient HLA-DQ8 transgenic mice. Int Immunol. 2002 Jul; 14(7):801-12.
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  38. Kudva YC, Deng YJ, Govindarajan R, Abraham RS, Marietta EV, Notkins AL, David CS. HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2. Hum Immunol. 2001 Oct; 62(10):1099-105.
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  39. Singh VK, Rajagopalan G, Naik S, Kumar A. The effect of hairpin structure on PCR amplification efficiency. Molecular Biology Today. 2000; 1:67-9.
  40. Rajagopalan G, Verma PC, Jaiswal TN. Chicken Natural Killer cells. Target susceptibility and modulation by interferon inducers. Indian J Anim Sci. 1998:68.
  41. Rajagopalan G, Jaiswal TN, Mishra SC. Evaluation of MTT for determining cell proliferation and survival. Int J Anim Sci. 1997; 12:265-68.
  42. Oumachigui A, Rajagopalan G, Reddy R, Prabhavathy R, Chakravarty A. Placenta accreta and percreta: a review of 5 cases. Int J Gynaecol Obstet. 1981 Aug; 19(4):337-40.