Publications

  1. Hodgson DM, Behfar A, Zingman LV, Kane GC, Perez-Terzic C, Alekseev AE, Puceat M, Terzic A. Stable benefit of embryonic stem cell therapy in myocardial infarction. Am J Physiol Heart Circ Physiol. 2004 Aug; 287(2):H471-9.
    View PubMed
  2. Behfar A, Hodgson DM, Zingman LV, Perez-Terzic C, Yamada S, Kane GC, Alekseev AE, Puceat M, Terzic A. Administration of allogenic stem cells dosed to secure cardiogenesis and sustained infarct repair. Ann N Y Acad Sci. 2005 May; 1049:189-98.
    View PubMed
  3. Kane GC, Behfar A, Yamada S, Perez-Terzic C, O'Cochlain F, Reyes S, Dzeja PP, Miki T, Seino S, Terzic A. ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits. Diabetes. 2004 Dec; 53 Suppl 3:S169-75.
    View PubMed
  4. Kane GC, Behfar A, Dyer RB, O'Cochlain DF, Liu XK, Hodgson DM, Reyes S, Miki T, Seino S, Terzic A. KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension. Hum Mol Genet. 2006 Aug 1; 15(15):2285-97. Epub 2006 Jun 16.
    View PubMed
  5. Behfar A, Terzic A. Derivation of a cardiopoietic population from human mesenchymal stem cells yields cardiac progeny. Nat Clin Pract Cardiovasc Med. 2006 Mar; 3 Suppl 1:S78-82.
    View PubMed
  6. Yamada S, Kane GC, Behfar A, Liu XK, Dyer RB, Faustino RS, Miki T, Seino S, Terzic A. Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant. J Physiol. 2006 Dec 15; 577(Pt 3):1053-65. Epub 2006 Oct 12.
    View PubMed
  7. Behfar A, Perez-Terzic C, Faustino RS, Arrell DK, Hodgson DM, Yamada S, Puceat M, Niederlander N, Alekseev AE, Zingman LV, Terzic A. Cardiopoietic programming of embryonic stem cells for tumor-free heart repair. J Exp Med. 2007 Feb 19; 204(2):405-20. Epub 2007 Feb 05.
    View PubMed
  8. Chung S, Dzeja PP, Faustino RS, Perez-Terzic C, Behfar A, Terzic A. Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells. Nat Clin Pract Cardiovasc Med. 2007 Feb; 4 Suppl 1:S60-7.
    View PubMed
  9. Behfar A, Terzic A. Cardioprotective repair through stem cell-based cardiopoiesis. J Appl Physiol (1985). 2007 Oct; 103(4):1438-40. Epub 2007 Jul 19.
    View PubMed
  10. Arrell DK, Niederlander NJ, Faustino RS, Behfar A, Terzic A. Cardioinductive network guiding stem cell differentiation revealed by proteomic cartography of tumor necrosis factor alpha-primed endodermal secretome. Stem Cells. 2008 Feb; 26(2):387-400. Epub 2007 Nov 08.
    View PubMed
  11. Nelson TJ, Faustino RS, Chiriac A, Crespo-Diaz R, Behfar A, Terzic A. CXCR4+/FLK-1+ biomarkers select a cardiopoietic lineage from embryonic stem cells. Stem Cells. 2008 Jun; 26(6):1464-73. Epub 2008 Mar 27.
    View PubMed
  12. Nelson T, Behfar A, Terzic A. Stem cells: biologics for regeneration. Clin Pharmacol Ther. 2008 Nov; 84(5):620-3. Epub 2008 Aug 13.
    View PubMed
  13. Behfar A, Faustino RS, Arrell DK, Dzeja PP, Perez-Terzic C, Terzic A. Guided stem cell cardiopoiesis: discovery and translation. J Mol Cell Cardiol. 2008 Oct; 45(4):523-9. Epub 2008 Sep 26.
    View PubMed
  14. Yamada S, Nelson TJ, Crespo-Diaz RJ, Perez-Terzic C, Liu XK, Miki T, Seino S, Behfar A, Terzic A. Embryonic stem cell therapy of heart failure in genetic cardiomyopathy. Stem Cells. 2008 Oct; 26(10):2644-53. Epub 2008 Jul 31.
    View PubMed
  15. Faustino RS, Behfar A, Perez-Terzic C, Terzic A. Genomic chart guiding embryonic stem cell cardiopoiesis. Genome Biol. 2008; 9(1):R6. Epub 2008 Jan 09.
    View PubMed
  16. Nelson TJ, Chiriac A, Faustino RS, Crespo-Diaz RJ, Behfar A, Terzic A. Lineage specification of Flk-1+ progenitors is associated with divergent Sox7 expression in cardiopoiesis. Differentiation. 2009 Mar; 77(3):248-55. Epub 2008 Dec 02.
    View PubMed
  17. Yamada S, Nelson TJ, Behfar A, Crespo-Diaz RJ, Fraidenraich D, Terzic A. Stem cell transplant into preimplantation embryo yields myocardial infarction-resistant adult phenotype. Stem Cells. 2009 Jul; 27(7):1697-705.
    View PubMed
  18. Nelson TJ , Behfar A , Terzic A . Strategies for therapeutic repair: The "R(3)" regenerative medicine paradigm. Clin Transl Sci 2008 Sep; 1 (2):168-171
    View PubMed
  19. Nelson TJ , Behfar A , Yamada S , Martinez-Fernandez A , Terzic A . Stem cell platforms for regenerative medicine. Clin Transl Sci 2009 Jun; 2 (3):222-7
    View PubMed
  20. Gersh BJ, Simari RD, Behfar A, Terzic CM, Terzic A. Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc. 2009 Oct; 84(10):876-92.
    View PubMed
  21. Chiriac A, Nelson TJ, Faustino RS, Behfar A, Terzic A. Cardiogenic induction of pluripotent stem cells streamlined through a conserved SDF-1/VEGF/BMP2 integrated network. PLoS One. 2010; 5(4):e9943. Epub 2010 Apr 01.
    View PubMed
  22. Behfar A , Terzic A . Mesenchymal stem cells: engineering regeneration. Clin Transl Sci 2008 May; 1 (1):34-5
    View PubMed
  23. Faustino RS, Chiriac A, Niederlander NJ, Nelson TJ, Behfar A, Mishra PK, Macura S, Michalak M, Terzic A, Perez-Terzic C. Decoded calreticulin-deficient embryonic stem cell transcriptome resolves latent cardiophenotype. Stem Cells. 2010 Jul; 28(7):1281-91.
    View PubMed
  24. Behfar A, Crespo-Diaz R, Nelson TJ, Terzic A, Gersh BJ. Stem cells: clinical trials results the end of the beginning or the beginning of the end? Cardiovasc Hematol Disord Drug Targets. 2010 Sep 1; 10(3):186-201.
    View PubMed
  25. Behfar A, Yamada S, Crespo-Diaz R, Nesbitt JJ, Rowe LA, Perez-Terzic C, Gaussin V, Homsy C, Bartunek J, Terzic A. Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction. J Am Coll Cardiol. 2010 Aug 24; 56(9):721-34.
    View PubMed
  26. Dzeja PP, Chung S, Faustino RS, Behfar A, Terzic A. Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation. PLoS One. 2011; 6(4):e19300. Epub 2011 Apr 27.
    View PubMed
  27. Muller O, Delrue L, Hamilos M, Vercauteren S, Ntalianis A, Trana C, Mangiacapra F, Dierickx K, De Bruyne B, Wijns W, Behfar A, Barbato E, Terzic A, Vanderheyden M, Bartunek J. Transcriptional fingerprint of human whole blood at the site of coronary occlusion in acute myocardial infarction. EuroIntervention. 2011 Aug; 7(4):458-66.
    View PubMed
  28. Crespo-Diaz R, Behfar A, Butler GW, Padley DJ, Sarr MG, Bartunek J, Dietz AB, Terzic A. Platelet lysate consisting of a natural repair proteome supports human mesenchymal stem cell proliferation and chromosomal stability. Cell Transplant. 2011; 20(6):797-811. Epub 2010 Nov 19.
    View PubMed
  29. Strege P, Beyder A, Bernard C, Crespo-Diaz R, Behfar A, Terzic A, Ackerman M, Farrugia G. Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells. Channels (Austin). 2012 Nov-Dec; 6(6):457-62. Epub 2012 Sep 27.
    View PubMed
  30. O'Cochlain DF, Perez-Terzic C, Reyes S, Kane GC, Behfar A, Hodgson DM, Strommen JA, Liu XK, van den Broek W, Wansink DG, Wieringa B, Terzic A. Transgenic overexpression of human DMPK accumulates into hypertrophic cardiomyopathy, myotonic myopathy and hypotension traits of myotonic dystrophy. Hum Mol Genet. 2004 Oct 15; 13(20):2505-18. Epub 2004 Aug 18.
    View PubMed
  31. Behfar A, Valles AG, Gulati R, Sandhu GS. Persistent angina uncovers unusual communication between the left anterior descending and circumflex arteries. Circulation. 2013 Jun 18; 127(24):2465-6.
    View PubMed
  32. Bartunek J, Behfar A, Dolatabadi D, Vanderheyden M, Ostojic M, Dens J, El Nakadi B, Banovic M, Beleslin B, Vrolix M, Legrand V, Vrints C, Vanoverschelde JL, Crespo-Diaz R, Homsy C, Tendera M, Waldman S, Wijns W, Terzic A. Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics. J Am Coll Cardiol. 2013 Jun 11; 61(23):2329-38. Epub 2013 Apr 10.
    View PubMed
  33. Yamada S, Arrell DK, Kane GC, Nelson TJ, Perez-Terzic CM, Behfar A, Purushothaman S, Prinzen FW, Auricchio A, Terzic A. Mechanical dyssynchrony precedes QRS widening in ATP-sensitive K(+) channel-deficient dilated cardiomyopathy. J Am Heart Assoc. 2013; 2(6):e000410. Epub 2013 Dec 05.
    View PubMed
  34. Behfar A, Latere JP, Bartunek J, Homsy C, Daro D, Crespo-Diaz RJ, Stalboerger PG, Steenwinckel V, Seron A, Redfield MM, Terzic A. Optimized delivery system achieves enhanced endomyocardial stem cell retention. Circ Cardiovasc Interv. 2013 Dec; 6(6):710-8. Epub 2013 Dec 10.
    View PubMed
  35. Behfar A, Latere JP, Bartunek J, Homsy C, Daro D, Crespo-Diaz RJ, Stalboerger PG, Steenwinckel V, Seron A, Redfield MM, Terzic A. Optimized delivery system achieves enhanced endomyocardial stem cell retention. Cell Biol Int. 2014 Jan; 38(1):710-8.
  36. Behfar A, Crespo-Diaz R, Terzic A, Gersh BJ. Cell therapy for cardiac repair--lessons from clinical trials. Nat Rev Cardiol. 2014 Apr; 11(4):232-46. Epub 2014 Mar 04.
    View PubMed
  37. Johnson TD, Dequach JA, Gaetani R, Ungerleider J, Elhag D, Nigam V, Behfar A, Christman KL. Human versus porcine tissue sourcing for an injectable myocardial matrix hydrogel. Biomater Sci. 2014; 2014:60283D.
    View PubMed
  38. Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol. 2013 Jan; 15(1):96-102. Epub 2012 Dec 16
    View PubMed
  39. Wyles CC , Houdek MT , Wyles SP , Wagner ER , Behfar A , Sierra RJ . Differential cytotoxicity of corticosteroids on human mesenchymal stem cells. Clin Orthop Relat Res 2015 Mar; 473 (3):1155-64 Epub 2014 Sept 04
    View PubMed
  40. Behfar A, Terzic A, Perez-Terzic CM. Regenerative principles enrich cardiac rehabilitation practice. Am J Phys Med Rehabil. 2014 Nov; 93(11 Suppl 3):S169-75.
    View PubMed
  41. Orde SR, Behfar A, Stalboerger PG, Barros-Gomes S, Kane GC, Oh JK. Effect of positive end-expiratory pressure on porcine right ventricle function assessed by speckle tracking echocardiography. BMC Anesthesiol 2015; 15:49 Epub 2015 Apr 11
    View PubMed
  42. Bansal A, Pandey MK, Demirhan YE, Nesbitt JJ, Crespo-Diaz RJ, Terzic A, Behfar A, DeGrado TR. Novel (89)Zr cell labeling approach for PET-based cell trafficking studies. EJNMMI Res 2015; 5:19 Epub 2015 Mar 28
    View PubMed
  43. Moulay G , Ohtani T , Ogut O , Guenzel A , Behfar A , Zakeri R , Haines P , Storlie J , Bowen L , Pham L , Kaye D , Sandhu G , O'Connor M , Russell S , Redfield M . Cardiac AAV9 Gene Delivery Strategies in Adult Canines: Assessment by Long-term Serial SPECT Imaging of Sodium Iodide Symporter Expression. Mol Ther 2015 Jul; 23 (7):1211-21 Epub 2015 Apr 27
    View PubMed
  44. Yamada S , Arrell DK , Martinez-Fernandez A , Behfar A , Kane GC , Perez-Terzic CM , Crespo-Diaz RJ , McDonald RJ , Wyles SP , Zlatkovic-Lindor J , Nelson TJ , Terzic A . Regenerative Therapy Prevents Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy. J Am Heart Assoc 2015 May; 4 (5) Epub 2015 May 11
    View PubMed
  45. Wyles CC, Houdek MT, Crespo-Diaz RJ, Norambuena GA, Stalboerger PG, Terzic A, Behfar A, Sierra RJ. Adipose-derived Mesenchymal Stem Cells Are Phenotypically Superior for Regeneration in the Setting of Osteonecrosis of the Femoral Head. Clin Orthop Relat Res 2015 Oct; 473 (10):3080-90 Epub 2015 June 13
    View PubMed
  46. Johnson TD, Hill RC, Dzieciatkowska M, Nigam V, Behfar A, Christman KL, Hansen KC. Quantification of decellularized human myocardial matrix: A comparison of six patients. Proteomics Clin Appl 2016 Jan; 10 (1):75-83 Epub 2015 Sept 28
    View PubMed
  47. Crespo-Diaz R , Yamada S , Bartunek J , Perez-Terzic C , de Waele P , Mauen S , Terzic A , Behfar A . Cardiopoietic index predicts heart repair fitness of patient-derived stem cells. Biomark Med 2015; 9 (7):639-49 Epub 2015 May 27
    View PubMed
  48. Banovic M, Loncar Z, Behfar A, Vanderheyden M, Beleslin B, Zeiher A, Metra M, Terzic A, Bartunek J. Endpoints in stem cell trials in ischemic heart failure. Stem Cell Res Ther. 2015; 6(1):159. Epub 2015 Aug 29.
    View PubMed
  49. Dalen M, Behfar A, Terzic A, Schiller P, Seron A, Sherman W, Mansson-Broberg A, Grinnemo KH. Percutaneous fluoroscopic-guided endomyocardial delivery in an experimental model of left ventricular assist device support. Journal Of Cardiovascular Translational Research. 2015 Aug; 8(6):381-4.
    View PubMed
  50. Wyles CC, Houdek MT, Behfar A, Sierra RJ. Mesenchymal stem cell therapy for osteoarthritis: current perspectives. Stem Cells Cloning. 2015; 8:117-24. Epub 2015 Aug 28.
    View PubMed
  51. Bartunek J, Vanderheyden M, Behfar A. Integrate and boost: bioscaffolds nurture the cardiac regenerative paradigm. Stem Cell Res Ther. 2015; 6:183. Epub 2015 Sep 23.
    View PubMed
  52. Houdek MT , Wyles CC , Packard BD , Terzic A , Behfar A , Sierra RJ . Decreased Osteogenic Activity of Mesenchymal Stem Cells in Patients With Corticosteroid-Induced Osteonecrosis of the Femoral Head. J Arthroplasty 2016 Apr; 31 (4):893-8 Epub 2015 Aug 29
    View PubMed
  53. Bartunek J, Davison B, Sherman W, Povsic T, Henry TD, Gersh B, Metra M, Filippatos G, Hajjar R, Behfar A, Homsy C, Cotter G, Wijns W, Tendera M, Terzic A. Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial design. Eur J Heart Fail 2016 Feb; 18 (2):160-8 Epub 2015 Dec 14
    View PubMed
  54. Faustino RS , Behfar A , Groenendyk J , Wyles SP , Niederlander N , Reyes S , Puceat M , Michalak M , Terzic A , Perez-Terzic C . Calreticulin secures calcium-dependent nuclear pore competency required for cardiogenesis. J Mol Cell Cardiol 2016 Mar; 92:63-74 Epub 2016 Jan 27
    View PubMed
  55. Terzic A , Behfar A . Stem cell therapy for heart failure: Ensuring regenerative proficiency. Trends Cardiovasc Med 2016 Jan 28 [Epub ahead of print]
    View PubMed
  56. Behfar A, Zingman LV, Hodgson DM, Rauzier JM, Kane GC, Terzic A, Puceat M. Stem cell differentiation requires a paracrine pathway in the heart FASEB J.;16()1558-1566.
  57. Behfar A, Perez-Terzic C, Mery A, van Deursen JM, Terzic A, Puceat M. Commitment of embryonic stem cells toward a cardiac lineage: Molecular mechanisms and evidence for a promising therapeutic approach for heart failure Circ Res.;93()444-452.
  58. Behfar A, Mery A, Papadimou E, Zeineddine D, Menard C, Zingman LV, Hodgson DM, Rauzier JM, Kane GC, Perez-Terzic C, Terzic A, Puceat M. Commitment of embryonic stem cells toward a cardaic lineage: Molecular mechanisms and evidence for a promising therapeutic approach for heart failure J Muscle Res Cell Motil.;24()269-274.
  59. Behfar A, Zeineddine D, Papadimou E, Chebli K, Gineste M, Liu J, Grey C, Thurig S, Wallace VA, Skerjanc IS, Puceat M. Oct-3/4 dose dependently regulates specification of embryonic stem cells toward a cardiac lineage and early heart development Dev Cell.;11()535-546.
  60. Behfar A, Terzic A. Optimizing adult mesenchymal stem cells for heart repair J Mol Cell Cardiol.;42()283-284.
  61. Behfar A, Perez-Terzic C, Faustino RS, Boorsma B, Arrell DK, Niederlander NJ, Terzic A. Stem cell transformation into cardiac phenotype guided by directed cell transformation involves remodeling of nuclear transport machinery Nature Clinical Practice Cardiovascular Medicine.;4()S68-S76.
  62. Behfar A, Arrell DK, Niederlander NJ, Perez-Terzic C, Chung S, Terzic A. Pharmacoproteomics: Advancing the efficacy and safety of regenerative therapeutics Clin Pharmacol Ther.;82()316-319.
  63. Behfar A, Yamada S, Nelson TJ, Crespo-Diaz RJ, Perez-Terzic C, Liu XK, Miki T, Seino S, Terzic A. Embryonic stem cell therapy of heart failure in genetic cardiomyopathy Stem Cells.;26()2644-2653.
  64. Behfar A, Bartunek J, Vanderheyden M, Wijns W, Terzic A. Mesenchymal stem cells and cardaic repair: Principles and practice J Cardiovasc Trans.;1()115-119.
  65. Behfar A, Chiriac A, Faustino RS, Nelson TJ, Terzic A. Cardiogenic induction of pluripotent stem cells streamlined through a conserved SDF-1/VEGF/BMP2 integrated network PLoS ONE.;5()e9943.
  66. Terzic A, Folmes CD, Martinez-Fernandez A, Behfar A. Regenerative medicine: On the vanguard of health care Mayo Clin Proc.86:600-602.
  67. Behfar A, Terzic A. Regenerative heart failure therapy headed for optimization Eur Heart J.;35()1231-1234.
  68. Behfar A, Terzic A. Stem cell in the rough: Repair quotient mined out of a bone marrow niche Circ Res.;115()814-816.
  69. Behfar A, Terzic A. Stem cells versus senescense: The yin and yang of cardiac health JACC.;65()148-150.
  70. Behfar A, Terzic A, Filippatos G. Clinical development plan for regenerative therapy in heart failure Eur J Heart Fail.;18()142-144.
  71. Houdek MT , Wyles CC , Stalboerger PG , Terzic A , Behfar A , Moran SL . Collagen and Fractionated Platelet-Rich Plasma Scaffold for Dermal Regeneration. Plast Reconstr Surg 2016 May; 137 (5):1498-506
    View PubMed