Publications

  1. Dhanasekaran R, Nakamura I, Hu C, Chen G, Oseini AM, Seven ES, Miamen AG, Moser CD, Zhou W, vanKuppevelt TH, vanDeursen J, Mounajjed T, Fernandez-Zapico ME, Roberts LR. Activation of the TGFbeta/SMAD transcriptional pathway underlies a novel tumor promoting role of sulfatase1 in hepatocellular carcinoma. Hepatology. 2014 Dec 12.
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  2. Mazzone A, Gibbons SJ, Bernard CE, Nowsheen S, Middha S, Almada LL, Ordog T, Kendrick ML, Reid Lombardo K, Shen KR, Galietta LJ, Fernandez-Zapico ME, Farrugia G. Identification and characterization of a novel promoter for the human ANO1 gene regulated by the transcription factor signal transducer and activator of transcription 6 (STAT6). FASEB J. 2014 Oct 28. [Epub ahead of print]
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  3. Mathew E, Collins MA, Fernandez-Barrena MG, Holtz AM, Yan W, Hogan JO, Tata Z, Allen BL, Fernandez-Zapico ME, di Magliano MP. The transcription factor GLI1 modulates the inflammatory response during pancreatic tissue remodeling. J Biol Chem. 2014 Oct 3; 289(40):27727-43. Epub 2014 Aug 07.
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  4. Mathew E, Collins MA, Fernandez-Barrena MG, Holtz AM, Yan W, Hogan JO, Tata Z, Allen BL, Fernandez-Zapico ME, Pasca di Magliano M. The Transcription Factor GLI1 Modulates the Inflammatory Response during Pancreatic Tissue Remodeling. J Biol Chem. 2014 Oct 3; 289(40):27727-43. Epub 2014 Aug 07.
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  5. Martinez-Bosch N, Fernandez-Barrena MG, Moreno M, Ortiz-Zapater E, Munne-Collado J, Iglesias M, Andre S, Gabius HJ, Hwang RF, Poirier F, Navas C, Guerra C, Fernandez-Zapico ME, Navarro P. Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation. Cancer Res. 2014 Jul 1; 74(13):3512-24. Epub 2014 May 08.
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  6. Villegas VE, Rahman MF, Fernandez-Barrena MG, Diao Y, Liapi E, Sonkoly E, Stahle M, Pivarcsi A, Annaratone L, Sapino A, Ramirez Clavijo S, Burglin TR, Shimokawa T, Ramachandran S, Kapranov P, Fernandez-Zapico ME, Zaphiropoulos PG. Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1. Mol Oncol. 2014 Jul; 8(5):912-26. Epub 2014 Mar 22.
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  7. Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, Westphalen CB, Kitajewski J, Fernandez-Barrena MG, Fernandez-Zapico ME, Iacobuzio-Donahue C, Olive KP, Stanger BZ. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell. 2014 Jun 16; 25(6):735-47. Epub 2014 May 22.
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  8. Mills LD, Zhang L, Marler R, Svingen P, Fernandez-Barrena MG, Dave M, Bamlet W, McWilliams RR, Petersen GM, Faubion W, Fernandez-Zapico ME. Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression. J Biol Chem. 2014 Jun 6; 289(23):16516-25. Epub 2014 Apr 15.
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  9. Baumgart S, Chen NM, Siveke JT, Konig A, Zhang JS, Singh SK, Wolf E, Bartkuhn M, Esposito I, Hessmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, Smyrk T, Bamlet WR, Eilers M, Neesse A, Gress TM, Billadeau DD, Tuveson D, Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D. Cancer Discov. 2014 Jun; 4(6):688-701. Epub 2014 Apr 02.
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  10. Nye MD, Almada LL, Fernandez-Barrena MG, Marks DL, Elsawa SF, Vrabel A, Tolosa EJ, Ellenrieder V, Fernandez-Zapico ME. The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor beta-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner. J Biol Chem. 2014 May 30; 289(22):15495-506. Epub 2014 Apr 16.
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  11. Higa A, Taouji S, Lhomond S, Jensen D, Fernandez-Zapico ME, Simpson JC, Pasquet JM, Schekman R, Chevet E. Endoplasmic reticulum stress-activated transcription factor ATF6 alpha requires the disulfide isomerase PDIA5 to modulate chemoresistance. Mol Cell Biol. 2014; 34(10):1839-49.
  12. Hogenson T, Lauth M, Pasca diMagliano M, Fernandez-Zapico M. Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis. F1000Res. 2014; 3:238. Epub 2014 Oct 08.
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  13. Zhang Y, Yang J, Cui X, Chen Y, Zhu VF, Hagan JP, Wang H, Yu X, Hodges SE, Fang J, Chiao PJ, Logsdon CD, Fisher WE, Brunicardi FC, Chen C, Yao Q, Fernandez-Zapico ME, Li M. A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. EMBO Mol Med. 2013 Sep; 5(9):1322-34. Epub 2013 Jul 16.
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  14. Gilabert M, Vaccaro MI, Fernandez-Zapico ME, Calvo EL, Turrini O, Secq V, Garcia S, Moutardier V, Lomberk G, Dusetti N, Urrutia R, Iovanna JL. Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs. J Cell Physiol. 2013 Sep; 228(9):1834-43.
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  15. Pluquet O, Dejeans N, Bouchecareilh M, Lhomond S, Pineau R, Higa A, Delugin M, Combe C, Loriot S, Cubel G, Dugot-Senant N, Vital A, Loiseau H, Gosline SJ, Taouji S, Hallett M, Sarkaria JN, Anderson K, Wu W, Rodriguez FJ, Rosenbaum J, Saltel F, Posttranscriptional regulation of PER1 underlies the oncogenic function of IREalpha. Cancer Res. 2013 Aug 1; 73(15):4732-43. Epub 2013 Jun 10.
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  16. Nakamura I, Fernandez-Barrena MG, Ortiz-Ruiz MC, Almada LL, Hu C, Elsawa SF, Mills LD, Romecin PA, Gulaid KH, Moser CD, Han JJ, Vrabel A, Hanse EA, Akogyeram NA, Albrecht JH, Monga SP, Sanderson SO, Prieto J, Roberts LR, Fernandez-Zapico ME. Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. J Biol Chem. 2013 Jul 19; 288(29):21389-98. Epub 2013 Jun 05.
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  17. Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R. Kruppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. J Biol Chem. 2013 Jun 14; 288(24):17745-58. Epub 2013 Apr 15.
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  18. Mills LD, Zhang Y, Marler RJ, Herreros-Villanueva M, Zhang L, Almada LL, Couch F, Wetmore C, Pasca di Magliano M, Fernandez-Zapico ME. Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation. J Biol Chem. 2013 Apr 26; 288(17):11786-94. Epub 2013 Mar 12.
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  19. Iovanna JL, Marks DL, Fernandez-Zapico ME, Urrutia R. Mechanistic insights into self-reinforcing processes driving abnormal histogenesis during the development of pancreatic cancer. Am J Pathol. 2013 Apr; 182(4):1078-86. Epub 2013 Jan 31.
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  20. Baumgart S, Ellenrieder V, Fernandez-Zapico ME. Oncogenic transcription factors: cornerstones of inflammation-linked pancreatic carcinogenesis. Gut. 2013 Feb; 62(2):310-6. Epub 2011 Oct 13.
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  21. McCleary-Wheeler AL, Lomberk GA, Weiss FU, Schneider G, Fabbri M, Poshusta TL, Dusetti NJ, Baumgart S, Iovanna JL, Ellenrieder V, Urrutia R, Fernandez-Zapico ME. Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis. Cancer Lett. 2013 Jan 28; 328(2):212-21. Epub 2012 Oct 13.
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  22. Mathison A, Grzenda A, Lomberk G, Velez G, Buttar N, Tietz P, Hendrickson H, Liebl A, Xiong YY, Gores G, Fernandez-Zapico M, Larusso NF, Faubion W, Shah VH, Urrutia R. Role for Kruppel-like transcription factor 11 in mesenchymal cell function and fibrosis. PLoS One. 2013; 8(9):e75311. Epub 2013 Sep 17.
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  23. Aggarwal G, Ramachandran V, Javeed N, Arumugam T, Dutta S, Klee GG, Klee EW, Smyrk TC, Bamlet W, Han JJ, Rumie Vittar NB, de Andrade M, Mukhopadhyay D, Petersen GM, Fernandez-Zapico ME, Logsdon CD, Chari ST. Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in beta cells and mice. Gastroenterology. 2012 Dec; 143(6):1510-1517.e1. Epub 2012 Sep 06.
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  24. Lo Re AE, Fernandez-Barrena MG, Almada LL, Mills LD, Elsawa SF, Lund G, Ropolo A, Molejon MI, Vaccaro MI, Fernandez-Zapico ME. Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells. J Biol Chem. 2012 Jul 20; 287(30):25325-34. Epub 2012 Apr 25
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  25. Joost S, Almada LL, Rohnalter V, Holz PS, Fernandez-Barrena MG, Fernandez-Zapico ME, Lauth M. GLI1 Modulates EMT in Pancreatic Cancer--Response. Cancer Res. 2012 Jul 15; 72(14):3704-5. Epub 2012 Jul 03.
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  26. Lomberk G, Mathison AJ, Grzenda A, Seo S, DeMars CJ, Rizvi S, Bonilla-Velez J, Calvo E, Fernandez-Zapico ME, Iovanna J, Buttar NS, Urrutia R. Sequence-specific recruitment of heterochromatin protein 1 via interaction with Kruppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases. J Biol Chem. 2012 Apr 13; 287(16):13026-39. Epub 2012 Feb 08.
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  27. Baumgart S, Glesel E, Singh G, Chen NM, Reutlinger K, Zhang J, Billadeau DD, Fernandez-Zapico ME, Gress TM, Singh SK, Ellenrieder V. Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer. Gastroenterology. 2012 Feb; 142(2):388-98.e1-7. Epub 2011 Nov 10.
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  28. Joost S, Almada LL, Rohnalter V, Holz PS, Vrabel AM, Fernandez-Barrena MG, McWilliams RR, Krause M, Fernandez-Zapico ME, Lauth M. GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells. Cancer Res. 2012 Jan 1; 72(1):88-99. Epub 2011 Nov 15.
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  29. McCleary-Wheeler AL, McWilliams R, Fernandez-Zapico ME. Aberrant signaling pathways in pancreatic cancer: a two compartment view. Mol Carcinog. 2012 Jan; 51(1):25-39.
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  30. Zheng X, Vittar NB, Gai X, Fernandez-Barrena MG, Moser CD, Hu C, Almada LL, McCleary-Wheeler AL, Elsawa SF, Vrabel AM, Shire AM, Comba A, Thorgeirsson SS, Kim Y, Liu Q, Fernandez-Zapico ME, Roberts LR. The transcription factor GLI1 mediates TGFbeta1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism. PLoS One. 2012; 7(11):e49581. Epub 2012 Nov 19.
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  31. Elsawa SF, Novak AJ, Ziesmer SC, Almada LL, Hodge LS, Grote DM, Witzig TE, Fernandez-Zapico ME, Ansell SM. Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity. Blood. 2011 Nov 17; 118(20):5540-9. Epub 2011 Sep 14.
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  32. Douglas AE, Heim JA, Shen F, Almada LL, Riobo NA, Fernandez-Zapico ME, Manning DR. The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. J Biol Chem. 2011 Sep 2; 286(35):30714-22. Epub 2011 Jul 11.
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  33. Zhang JS, Koenig A, Harrison A, Ugolkov AV, Fernandez-Zapico ME, Couch FJ, Billadeau DD. Mutant K-Ras increases GSK-3beta gene expression via an ETS-p300 transcriptional complex in pancreatic cancer. Oncogene. 2011 Aug 25; 30(34):3705-15. Epub 2011 Mar 28.
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  34. Singh SK, Baumgart S, Singh G, Konig AO, Reutlinger K, Hofbauer LC, Barth P, Gress TM, Lomberk G, Urrutia R, Fernandez-Zapico ME, Ellenrieder V. Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid. J Biol Chem. 2011 Aug 19; 286(33):28761-71. Epub 2011 May 31.
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  35. Colvin Wanshura LE, Galvin KE, Ye H, Fernandez-Zapico ME, Wetmore C. Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells. Cancer Res. 2011 Aug 1; 71(15):5336-45. Epub 2011 Jun 06.
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  36. Beltran E, Fresquet V, Martinez-Useros J, Richter-Larrea JA, Sagardoy A, Sesma I, Almada LL, Montes-Moreno S, Siebert R, Gesk S, Calasanz MJ, Malumbres R, Rieger M, Prosper F, Lossos IS, Piris MA, Fernandez-Zapico ME, Martinez-Climent JA. A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma. Proceedings Of The National Academy Of Sciences Of The United States Of. 2011 Jul 26; 108(30):12461-6.
  37. Elsawa SF, Almada LL, Ziesmer SC, Novak AJ, Witzig TE, Ansell SM, Fernandez-Zapico ME. GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment. J Biol Chem. 2011 Jun 17; 286(24):21524-34. Epub 2011 Mar 18.
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  38. Singh SK, Dobes S, Singh G, Koenig AO, Reutlinger K, Hofbauer LC, Barth P, Gress TM, Lomberk G, Urrutia R, Fernandez-Zapico ME, Ellenrieder V. Disruption of a nuclear NFATc2 stabilization loop confers breast and pancreatic cancer growth supression by zoledronic acid. J Biol Chem. 2011 May 31.
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  39. Fernandez-Zapico ME, Lomberk GA, Tsuji S, DeMars CJ, Bardsley MR, Lin YH, Almada LL, Han JJ, Mukhopadhyay D, Ordog T, Buttar NS, Urrutia R. A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth. Biochem J. 2011 Apr 15; 435(2):529-37.
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  40. Kurita S, Mott JL, Cazanave SC, Fingas CD, Guicciardi ME, Bronk SF, Roberts LR, Fernandez-Zapico ME, Gores GJ. Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. PLoS One. 2011; 6(3):e18330. Epub 2011 Mar 31.
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  41. Pereira Tde A, Witek RP, Syn WK, Choi SS, Bradrick S, Karaca GF, Agboola KM, Jung Y, Omenetti A, Moylan CA, Yang L, Fernandez-Zapico ME, Jhaveri R, Shah VH, Pereira FE, Diehl AM. Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma. Lab Invest. 2010 Dec; 90(12):1690-703. Epub 2010 Aug 9
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  42. Lai JP, Oseini AM, Moser CD, Yu C, Elsawa SF, Hu C, Nakamura I, Han T, Aderca I, Isomoto H, Garrity-Park MM, Shire AM, Li J, Sanderson SO, Adjei AA, Fernandez-Zapico ME, Roberts LR. The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation. Hepatology. 2010 Nov; 52(5):1680-9.
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  43. Rizvi S, Demars CJ, Comba A, Gainullin VG, Rizvi Z, Almada LL, Wang K, Lomberk G, Fernandez-Zapico ME, Buttar NS. Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis. Cancer Res. 2010 Sep 1; 70(17):6787-96. Epub 2010 Jul 20.
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  44. Singh G, Singh SK, Konig A, Reutlinger K, Nye MD, Adhikary T, Eilers M, Gress TM, Fernandez-Zapico ME, Ellenrieder V. Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation. J Biol Chem. 2010 Aug 27; 285(35):27241-50. Epub 2010 Jun 01.
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  45. Kurita S, Mott JL, Almada LL, Bronk SF, Werneburg NW, Sun SY, Roberts LR, Fernandez-Zapico ME, Gores GJ. GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis. Oncogene. 2010 Aug 26; 29(34):4848-58. Epub 2010 Jun 21.
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  46. Mott JL, Kurita S, Cazanave SC, Bronk SF, Werneburg NW, Fernandez-Zapico ME. Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB. J Cell Biochem. 2010 Aug 1; 110(5):1155-64.
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  47. Buttar NS, DeMars CJ, Lomberk G, Rizvi S, Bonilla-Velez J, Achra S, Rashtak S, Wang KK, Fernandez-Zapico ME, Urrutia R. Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis. J Biol Chem. 2010 Apr 9; 285(15):11433-44. Epub 2010 Feb 12.
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  48. Koenig A, Linhart T, Schlengemann K, Reutlinger K, Wegele J, Adler G, Singh G, Hofmann L, Kunsch S, Buch T, Schafer E, Gress TM, Fernandez-Zapico ME, Ellenrieder V. NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells. Gastroenterology. 2010 Mar; 138(3):1189-99.e1-2. Epub 2009 Nov 06.
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  49. Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 2010 Jan 22; 140(2):246-56.
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  50. O'Hara SP, Splinter PL, Gajdos GB, Trussoni CE, Fernandez-Zapico ME, Chen XM, LaRusso NF. NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection. J Biol Chem. 2010 Jan 1; 285(1):216-25. Epub 2009 Nov 10.
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  51. Konig A, Fernandez-Zapico ME, Ellenrieder V. Primers on molecular pathways--the NFAT transcription pathway in pancreatic cancer. Pancreatology. 2010; 10(4):416-22. Epub 2010 Aug 19.
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  52. Williams JA, Fernandez-Zapico. Modeling a scientific career: an essential component of the mentorship process. An interview with John A. Williams, Professor of Molecular and Integrative Physiology, University Of Michigan, Ann Arbor, Mich., USA by Martin E. Fernandez-Zapico. Pancreatology. 2010; 10(1):1-3. Epub 2010 Jan 26.
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  53. Fernandez-Zapico ME, van Velkinburgh JC, Gutierrez-Aguilar R, Neve B, Froguel P, Urrutia R, Stein R. MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. J Biol Chem. 2009 Dec 25; 284(52):36482-90. Epub 2009 Oct 20
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  54. Truty MJ, Lomberk G, Fernandez-Zapico ME, Urrutia R. Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling. J Biol Chem. 2009 Mar 6; 284(10):6291-300. Epub 2008 Dec 15.
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  55. Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernandez-Zapico ME, Hanahan D. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev. 2009 Jan 1; 23(1):24-36.
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  56. Fernandez-Zapico ME. Primers on molecular pathways GLI: more than just Hedgehog? Pancreatology. 2008; 8(3):227-9. Epub 2008 May 22.
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  57. Valentich MA, Fernandez-Zapico ME. Chapter in "Histologia y Embriologia del ser humano. Bases Celulares y Moleculares. 2008.
  58. Ougolkov AV, Bone ND, Fernandez-Zapico ME, Kay NE, Billadeau DD. Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells. Blood. 2007 Jul 15; 110(2):735-42. Epub 2007 Apr 26.
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  59. Nolz JC, Fernandez-Zapico ME, Billadeau DD. TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation. J Immunol. 2007 Jul 15; 179(2):1104-12.
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  60. Das A, Fernandez-Zapico ME, Cao S, Yao J, Fiorucci S, Hebbel RP, Urrutia R, Shah VH. Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration. J Biol Chem. 2006 Dec 22; 281(51):39105-13. Epub 2006 Oct 27.
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  61. Ougolkov AV, Fernandez-Zapico ME, Bilim VN, Smyrk TC, Chari ST, Billadeau DD. Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation. Clin Cancer Res. 2006 Sep 1; 12(17):5074-81.
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  62. Buttar NS, Fernandez-Zapico ME, Urrutia R. Key role of Kruppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias. Curr Opin Gastroenterol. 2006 Sep; 22(5):505-11.
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  63. Lomberk G, Bensi D, Fernandez-Zapico ME, Urrutia R. Evidence for the existence of an HP1-mediated subcode within the histone code. Nat Cell Biol. 2006 Apr; 8(4):407-15. Epub 2006 Mar 12.
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  64. Houghton SG, Zarroug AE, Duenes JA, Fernandez-Zapico ME, Sarr MG. The diurnal periodicity of hexose transporter mRNA and protein levels in the rat jejunum: role of vagal innervation. Surgery. 2006 Apr; 139(4):542-9.
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  65. Toruner M, Fernandez-Zapico M, Sha JJ, Pham L, Urrutia R, Egan LJ. Antianoikis effect of nuclear factor-kappaB through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1. J Biol Chem. 2006 Mar 31; 281(13):8686-96. Epub 2006 Jan 05.
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  66. Natesampillai S, Fernandez-Zapico ME, Urrutia R, Veldhuis JD. A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function. J Biol Chem. 2006 Feb 10; 281(6):3040-7. Epub 2005 Nov 22.
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  67. Kalinec GM, Fernandez-Zapico ME, Urrutia R, Esteban-Cruciani N, Chen S, Kalinec F. Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss. Proc Natl Acad Sci U S A. 2005 Nov 1; 102(44):16019-24. Epub 2005 Oct 20.
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  68. Lomberk G, Fernandez-Zapico ME, Urrutia R. When developmental signaling pathways go wrong and their impact on pancreatic cancer development. Curr Opin Gastroenterol. 2005 Sep; 21(5):555-60.
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  69. Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, Dina C, Hamid YH, Joly E, Vaillant E, Benmezroua Y, Durand E, Bakaher N, Delannoy V, Vaxillaire M, Cook T, Dallinga-Thie GM, Jansen H, Charles MA, Clement K, Galan P, Hercberg S, Helbecque N, Charpentier G Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. Proc Natl Acad Sci U S A. 2005 Mar 29; 102(13):4807-12. Epub 2005 Mar 17.
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  70. Ougolkov AV, Fernandez-Zapico ME, Savoy DN, Urrutia RA, Billadeau DD. Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res. 2005 Mar 15; 65(6):2076-81.
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  71. Cao S, Fernandez-Zapico ME, Jin D, Puri V, Cook TA, Lerman LO, Zhu XY, Urrutia R, Shah V. KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling. J Biol Chem. 2005 Jan 21; 280(3):1901-10. Epub 2004 Nov 05.
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  72. Fernandez-Zapico ME, Gonzalez-Paz NC, Weiss E, Savoy DN, Molina JR, Fonseca R, Smyrk TC, Chari ST, Urrutia R, Billadeau DD. Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell. 2005 Jan; 7(1):39-49.
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  73. Fernandez-Zapico ME, Urrutia R. Molecular pathways of pancreatic carcinogenesis. Drug Discovery Today: Disease Mechanisms. 2004; 1(2):247-52.
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  74. Fernandez-Zapico ME, Mladek A, Ellenrieder V, Folch-Puy E, Miller L, Urrutia R. An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation. EMBO J. 2003 Sep 15; 22(18):4748-58.
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  75. Fernandez-Zapico ME, Callahan G, Delgado S, Urrutia R. Expression profiling in pancreatic cancer research: the initial steps and the road ahead. Curr Opin Gastroenterol. 2003 Sep; 19(5):467-72.
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  76. Fernandez-Zapico ME, Bramati PS, Zakaria S, Kaczynski JA, Urrutia R. Fundamentals of transcription factors and their impact on pancreatic development and cancer. Pancreatology. 2003; 3(4):276-83.
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  77. Kaczynski JA, Conley AA, Fernandez Zapico M, Delgado SM, Zhang JS, Urrutia R. Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. Biochem J. 2002 Sep 15; 366(Pt 3):873-82.
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  78. Fernandez-Zapico ME, Kaczynski JA, Urrutia R. Pancreatic cancer research: challenges, opportunities, and recent developments. Curr Opin Gastroenterol. 2002 Sep; 18(5):563-7.
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  79. Ellenrieder V, Fernandez Zapico ME, Urrutia R. TGFbeta-mediated signaling and transcriptional regulation in pancreatic development and cancer. Curr Opin Gastroenterol. 2001 Sep; 17(5):434-40.
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  80. Fernandez Zapico ME, Ahmad US, Urrutia R. DNA microarrays: revolutionary insight into the living genome. Surgery. 2001 Sep; 130(3):403-7.
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  81. Gebelein B, Fernandez-Zapico M, Imoto M, Urrutia R. KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1. J Clin Invest. 1998 Dec 1; 102(11):1911-9.
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  82. Barotto NN, Lopez CB, Eynard AR, Fernandez Zapico ME, Valentich MA. Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis. Cancer Lett. 1998 Jul 3; 129(1):1-6.
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