Publications

  1. Poland GA, Ovsyannikova IG, Kennedy RB. Personalized vaccinology: A review. Vaccine. 2017 Jul 31; : ().
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  2. Haralambieva IH, Ovsyannikova IG, Kennedy RB, Larrabee BR, Zimmermann MT, Grill DE, Schaid DJ, Poland GA. Genome-wide associations of CD46 and IFI44L genetic variants with neutralizing antibody response to measles vaccine. Hum Genet. 2017 Apr; 136: (4)421-435.
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  3. Schaid DJ, Haralambieva IH, Larrabee BR, Ovsyannikova IG, Kennedy RB, Poland GA. Heritability of vaccine-induced measles neutralizing antibody titers. Vaccine. 2017 Mar 07; 35 (10):1390-1394 Epub 2017 Feb 08
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  4. Ovsyannikova IG, Schaid DJ, Larrabee BR, Haralambieva IH, Kennedy RB, Poland GA. A large population-based association study between HLA and KIR genotypes and measles vaccine antibody responses. PLoS One. 2017; 12 (2):e0171261 Epub 2017 Feb 03
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  5. Zimmermann MT, Kennedy RB, Grill DE, Oberg AL, Goergen KM, Ovsyannikova IG, Haralambieva IH, Poland GA. Integration of Immune Cell Populations, mRNA-Seq, and CpG Methylation to Better Predict Humoral Immunity to Influenza Vaccination: Dependence of mRNA-Seq/CpG Methylation on Immune Cell Populations. Front Immunol. 2017; 8:445 Epub 2017 Apr 21
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  6. Ovsyannikova IG, Salk HM, Kennedy RB, Haralambieva IH, Zimmermann MT, Grill DE, Oberg AL, Poland GA. Gene signatures associated with adaptive humoral immunity following seasonal influenza AH1N1 vaccination. Genes Immun. 2016 Dec; 17: (7)371-379.
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  7. Kennedy RB. Pushing Forward With Zika Vaccines. EBioMedicine 2016 Nov; 13:29-30 Epub 2016 Oct 13
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  8. Schaid DJ, Tong X, Larrabee B, Kennedy RB, Poland GA, Sinnwell JP. Statistical Methods for Testing Genetic Pleiotropy. Genetics. 2016 Oct; 204: (2)483-497.
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  9. Voigt EA, Ovsyannikova IG, Haralambieva IH, Kennedy RB, Larrabee BR, Schaid DJ, Poland GA. Genetically defined race, but not sex, is associated with higher humoral and cellular immune responses to measles vaccination. Vaccine. 2016 Sep 22; 34 (41):4913-4919 Epub 2016 Aug 30
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  10. Voigt EA, Kennedy RB, Poland GA. Defending against smallpox: a focus on vaccines. Expert Rev Vaccines. 2016 Sep; 15 (9):1197-211 Epub 2016 Apr 28
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  11. Haralambieva IH, Ovsyannikova IG, Kennedy RB, Zimmermann MT, Grill DE, Oberg AL, Poland GA. Transcriptional signatures of influenza A/H1N1-specific IgG memory-like B cell response in older individuals. Vaccine. 2016 Jul 25; 34: (34)3993-4002.
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  12. Rubin S, Kennedy R, Poland G. Emerging Mumps Infection. Pediatr Infect Dis J. 2016 Jul; 35: (7)799-801.
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  13. Kennedy RB, Simon WL, Gibson MJ, Goergen KM, Grill DE, Oberg AL, Poland GA. The composition of immune cells serves as a predictor of adaptive immunity in a cohort of 50- to 74-year-old adults. Immunology. 2016 Jul; 148: (3)266-75.
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  14. Kennedy RB, Poland GA, Ovsyannikova IG, Oberg AL, Asmann YW, Grill DE, Vierkant RA, Jacobson RM. Impaired innate, humoral, and cellular immunity despite a take in smallpox vaccine recipients. Vaccine. 2016 Jun 14; 34: (28)3283-90.
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  15. Lareau CA, White BC, Oberg AL, Kennedy RB, Poland GA, McKinney BA. An interaction quantitative trait loci tool implicates epistatic functional variants in an apoptosis pathway in smallpox vaccine eQTL data. Genes Immun. 2016 Jun; 17: (4)244-50.
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  16. Ovsyannikova IG, Oberg AL, Kennedy RB, Zimmermann MT, Haralambieva IH, Goergen KM, Grill DE, Poland GA. Gene signatures related to HAI response following influenza AH1N1 vaccine in older individuals. Heliyon. 2016 May; 2: (5)e00098.
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  17. Poland GA, Whitaker JA, Poland CM, Ovsyannikova IG, Kennedy RB. Vaccinology in the third millennium: scientific and social challenges. Curr Opin Virol. 2016 Apr; 17: ()116-25.
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  18. Zimmermann MT, Oberg AL, Grill DE, Ovsyannikova IG, Haralambieva IH, Kennedy RB, Poland GA. System-Wide Associations between DNA-Methylation, Gene Expression, and Humoral Immune Response to Influenza Vaccination. PLoS One. 2016; 11: (3)e0152034.
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  19. Rahmani B, Zimmermann MT, Grill DE, Kennedy RB, Oberg AL, White BC, Poland GA, McKinney BA. Recursive Indirect-Paths Modularity (RIP-M) for Detecting Community Structure in RNA-Seq Co-expression Networks. Front Genet. 2016; 7: ()80.
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  20. McKinney BA, Lareau C, Oberg AL, Kennedy RB, Ovsyannikova IG, Poland GA. The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine. PLoS One. 2016; 11: (8)e0158016.
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  21. Haralambieva IH, Zimmermann MT, Ovsyannikova IG, Grill DE, Oberg AL, Kennedy RB, Poland GA. Whole Transcriptome Profiling Identifies CD93 and Other Plasma Cell Survival Factor Genes Associated with Measles-Specific Antibody Response after Vaccination. PLoS One. 2016; 11: (8)e0160970.
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  22. Salk HM, Simon WL, Lambert ND, Kennedy RB, Grill DE, Kabat BF, Poland GA. Taxa of the Nasal Microbiome Are Associated with Influenza-Specific IgA Response to Live Attenuated Influenza Vaccine. PLoS One. 2016; 11 (9):e0162803 Epub 2016 Sept 19
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  23. Kennedy RB, Ovsyannikova IG, Haralambieva IH, Oberg AL, Zimmermann MT, Grill DE, Poland GA. Immunosenescence-Related Transcriptomic and Immunologic Changes in Older Individuals Following Influenza Vaccination. Front Immunol. 2016; 7:450 Epub 2016 Nov 02
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  24. Haralambieva IH, Kennedy RB, Ovsyannikova IG, Whitaker JA, Poland GA. Variability in Humoral Immunity to Measles Vaccine: New Developments. Trends Mol Med. 2015 Dec; 21: (12)789-801.
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  25. Oberg AL, McKinney BA, Schaid DJ, Pankratz VS, Kennedy RB, Poland GA. Lessons learned in the analysis of high-dimensional data in vaccinomics. Vaccine. 2015 Sep 29; 33: (40)5262-70.
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  26. Kennedy RB, Tosh PK, Goergen KM, Grill DE, Oberg AL, Poland GA. Statistical modeling using early markers of innate immunity to explain variation in humoral responses to influenza vaccine in older adults. Vaccine. 2015 Jul 17; 33: (31)3682-8.
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  27. Chen W, Larrabee BR, Ovsyannikova IG, Kennedy RB, Haralambieva IH, Poland GA, Schaid DJ. Fine Mapping Causal Variants with an Approximate Bayesian Method Using Marginal Test Statistics. Genetics. 2015 Jul; 200: (3)719-36.
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  28. Lambert ND, Haralambieva IH, Kennedy RB, Ovsyannikova IG, Pankratz VS, Poland GA. Polymorphisms in HLA-DPB1 are associated with differences in rubella virus-specific humoral immunity after vaccination. J Infect Dis. 2015 Mar 15; 211: (6)898-905.
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  29. Haralambieva IH, Simon WL, Kennedy RB, Ovsyannikova IG, Warner ND, Grill DE, Poland GA. Profiling of measles-specific humoral immunity in individuals following two doses of MMR vaccine using proteome microarrays. Viruses. 2015 Mar 10; 7: (3)1113-33.
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  30. Haralambieva IH, Painter SD, Kennedy RB, Ovsyannikova IG, Lambert ND, Goergen KM, Oberg AL, Poland GA. The impact of immunosenescence on humoral immune response variation after influenza AH1N1 vaccination in older subjects. PLoS One. 2015; 10: (3)e0122282.
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  31. Kennedy RB, Ovsyannikova IG, Haralambieva IH, Lambert ND, Pankratz VS, Poland GA. Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination. Hum Genet. 2014 Nov; 133: (11)1407-17.
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  32. Ovsyannikova IG, Pankratz VS, Salk HM, Kennedy RB, Poland GA. HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study. Hum Genet. 2014 Sep; 133: (9)1083-92.
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  33. Kennedy RB, Ovsyannikova IG, Haralambieva IH, Lambert ND, Pankratz VS, Poland GA. Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. Immunogenetics. 2014 Aug; 66: (7-8)493-9.
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  34. Poland GA, Ovsyannikova IG, Kennedy RB, Lambert ND, Kirkland JL. A systems biology approach to the effect of aging, immunosenescence and vaccine response. Curr Opin Immunol. 2014 Aug; 29: ()62-8.
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  35. Kennedy RB, Ovsyannikova IG, Lambert ND, Haralambieva IH, Poland GA. The personal touch: strategies toward personalized vaccines and predicting immune responses to them. Expert Rev Vaccines. 2014 May; 13: (5)657-69.
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  36. Haralambieva IH, Salk HM, Lambert ND, Ovsyannikova IG, Kennedy RB, Warner ND, Pankratz VS, Poland GA. Associations between race, sex and immune response variations to rubella vaccination in two independent cohorts. Vaccine. 2014 Apr 7; 32: (17)1946-53.
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  37. Haralambieva IH, Lambert ND, Ovsyannikova IG, Kennedy RB, Larrabee BR, Pankratz VS, Poland GA. Associations between single nucleotide polymorphisms in cellular viral receptors and attachment factor-related genes and humoral immunity to rubella vaccination. PLoS One. 2014; 9: (6)e99997.
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  38. Simon WL, Salk HM, Ovsyannikova IG, Kennedy RB, Poland GA. Cytokine production associated with smallpox vaccine responses. Immunotherapy. 2014; 6: (10)1097-112.
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  39. Ovsyannikova IG, Haralambieva IH, Kennedy RB, O'Byrne MM, Pankratz VS, Poland GA. Genetic variation in IL18R1 and IL18 genes and Inteferon gamma ELISPOT response to smallpox vaccination: an unexpected relationship. J Infect Dis. 2013 Nov 1; 208: (9)1422-30.
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  40. Haralambieva IH, Ovsyannikova IG, Kennedy RB, Larrabee BR, Shane Pankratz V, Poland GA. Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals. Hum Immunol. 2013 Oct; 74: (10)1263-6.
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  41. Kennedy RB, Oberg AL, Ovsyannikova IG, Haralambieva IH, Grill D, Poland GA. Transcriptomic profiles of high and low antibody responders to smallpox vaccine. Genes Immun. 2013 Jul-Aug; 14: (5)277-85.
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  42. Poland GA, Kennedy RB, McKinney BA, Ovsyannikova IG, Lambert ND, Jacobson RM, Oberg AL. Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century. Semin Immunol. 2013 Apr; 25: (2)89-103.
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  43. Haralambieva IH, Ovsyannikova IG, Pankratz VS, Kennedy RB, Jacobson RM, Poland GA. The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches. Expert Rev Vaccines. 2013 Jan; 12: (1)57-70.
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  44. Haralambieva IH, Oberg AL, Ovsyannikova IG, Kennedy RB, Grill DE, Middha S, Bot BM, Wang VW, Smith DI, Jacobson RM, Poland GA. Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination. PLoS One. 2013; 8: (5)e62149.
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  45. Fridley BL, Jenkins GD, Grill DE, Kennedy RB, Poland GA, Oberg AL. Soft truncation thresholding for gene set analysis of RNA-seq data: application to a vaccine study. Sci Rep. 2013; 3:2898. Epub 2013 Oct 09.
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  46. McKinney BA, White BC, Grill DE, Li PW, Kennedy RB, Poland GA, Oberg AL. ReliefSeq: a gene-wise adaptive-K nearest-neighbor feature selection tool for finding gene-gene interactions and main effects in mRNA-Seq gene expression data. PLoS One. 2013; 8(12):e81527. Epub 2013 Dec 10.
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  47. Haralambieva IH, Oberg AL, Dhiman N, Ovsyannikova IG, Kennedy RB, Grill DE, Jacobson RM, Poland GA. High-dimensional gene expression profiling studies in high and low responders to primary smallpox vaccination. J Infect Dis. 2012 Nov 15; 206: (10)1512-20.
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  48. Ovsyannikova IG, Haralambieva IH, Kennedy RB, Pankratz VS, Vierkant RA, Jacobson RM, Poland GA. Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination. Gene. 2012 Nov 15; 510: (1)59-65.
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  49. Kennedy RB, Ovsyannikova IG, Pankratz VS, Haralambieva IH, Vierkant RA, Jacobson RM, Poland GA. Genome-wide genetic associations with IFNgamma response to smallpox vaccine. Hum Genet. 2012 Sep; 131: (9)1433-51.
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  50. Kennedy RB, Ovsyannikova IG, Pankratz VS, Haralambieva IH, Vierkant RA, Poland GA. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. Hum Genet. 2012 Sep; 131: (9)1403-21.
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  51. Cummins NW, Weaver EA, May SM, Croatt AJ, Foreman O, Kennedy RB, Poland GA, Barry MA, Nath KA, Badley AD. Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice. FASEB J. 2012 Jul; 26: (7)2911-8.
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  52. Ovsyannikova IG, Kennedy RB, O'Byrne M, Jacobson RM, Pankratz VS, Poland GA. Genome-wide association study of antibody response to smallpox vaccine. Vaccine. 2012 Jun 13; 30: (28)4182-9.
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  53. Kennedy RB, Ovsyannikova IG, Haralambieva IH, O'Byrne MM, Jacobson RM, Pankratz VS, Poland GA. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. Vaccine. 2012 Mar 09; 30: (12)2159-67.
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  54. Umlauf BJ, Haralambieva IH, Ovsyannikova IG, Kennedy RB, Pankratz VS, Jacobson RM, Poland GA. Associations between demographic variables and multiple measles-specific innate and cell-mediated immune responses after measles vaccination. Viral Immunol. 2012 Feb; 25: (1)29-36.
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  55. Poland GA, Kennedy RB, Ovsyannikova IG. Vaccinomics and personalized vaccinology: is science leading us toward a new path of directed vaccine development and discovery? PLoS Pathog. 2011 Dec; 7: (12)e1002344.
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  56. Haralambieva IH, Ovsyannikova IG, Kennedy RB, Vierkant RA, Pankratz VS, Jacobson RM, Poland GA. Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination. Vaccine. 2011 Oct 19; 29: (45)7883-95.
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  57. Umlauf BJ, Ovsyannikova IG, Haralambieva IH, Kennedy RB, Vierkant RA, Pankratz VS, Jacobson RM, Poland GA. Correlations between vaccinia-specific immune responses within a cohort of armed forces members. Viral Immunol. 2011 Oct; 24: (5)415-20.
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  58. Poland GA, Ovsyannikova IG, Kennedy RB, Haralambieva IH, Jacobson RM. Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections. OMICS. 2011 Sep; 15: (9)625-36.
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  59. Kennedy RB, Poland GA. The top five "game changers" in vaccinology: toward rational and directed vaccine development. OMICS. 2011 Sep; 15: (9)533-7.
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  60. Haralambieva IH, Ovsyannikova IG, Dhiman N, Kennedy RB, O'Byrne M, Pankratz VS, Jacobson RM, Poland GA. Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in humoral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 2011 Aug 1; 204: (3)433-41.
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  61. Oberg AL, Kennedy RB, Li P, Ovsyannikova IG, Poland GA. Systems biology approaches to new vaccine development. Curr Opin Immunol. 2011 Jun; 23: (3)436-43.
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  62. Oberg AL, Dhiman N, Grill DE, Ryan JE, Kennedy RB, Poland GA. Optimizing high dimensional gene expression studies for immune response following smallpox vaccination using Taqman(R) low density immune arrays. J Immunol Methods. 2011 Mar 07; 366: (1-2)69-78.
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  63. Kennedy RB, Poland GA. The identification of HLA class II-restricted T cell epitopes to vaccinia virus membrane proteins. Virology. 2010 Dec 20; 408: (2)232-40.
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  64. Dhiman N, Haralambieva IH, Kennedy RB, Vierkant RA, O'Byrne MM, Ovsyannikova IG, Jacobson RM, Poland GA. SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine. Immunogenetics. 2010 Apr; 62: (4)197-210.
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  65. Kennedy RB, Ovsyannikova IG, Vierkant RA, Jacobson RM, Poland GA. Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses. Hum Immunol. 2010 Feb; 71: (2)128-35.
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  66. Tosh PK, Kennedy RB, Vierkant RA, Jacobson RM, Poland GA. Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity. Viral Immunol. 2009 Dec; 22: (6)451-6.
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  67. Kennedy RB, Ovsyannikova I, Poland GA. Smallpox vaccines for biodefense. Vaccine. 2009 Nov 05; 27 Suppl 4: ()D73-9.
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  68. Kennedy R, Pankratz VS, Swanson E, Watson D, Golding H, Poland GA. Statistical approach to estimate vaccinia-specific neutralizing antibody titers using a high-throughput assay. Clin Vaccine Immunol. 2009 Aug; 16: (8)1105-12.
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  69. Kennedy RB, Ovsyannikova IG, Jacobson RM, Poland GA. The immunology of smallpox vaccines. Curr Opin Immunol. 2009 Jun; 21: (3)314-20.
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  70. Kennedy RB, Ovsyannikova IG, Pankratz VS, Vierkant RA, Jacobson RM, Ryan MA, Poland GA. Gender effects on humoral immune responses to smallpox vaccine. Vaccine. 2009 May 26; 27: (25-26)3319-23.
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  71. Kennedy R, Celis E. Multiple roles for CD4+ T cells in anti-tumor immune responses. Immunol Rev. 2008 Apr; 222:129-44.
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  72. Kennedy R, Poland GA. T-Cell epitope discovery for variola and vaccinia viruses. Rev Med Virol. 2007 Mar-Apr; 17(2):93-113.
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  73. Dhiman N, Ovsyannikova IG, Cunningham JM, Vierkant RA, Kennedy RB, Pankratz VS, Poland GA, Jacobson RM. Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. J Infect Dis. 2007 Jan 1; 195(1):21-9. Epub 2006 Nov 20.
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  74. Kennedy R, Celis E. T helper lymphocytes rescue CTL from activation-induced cell death. J Immunol. 2006 Sep 1; 177: (5)2862-72.
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  75. Kennedy R, Undale AH, Kieper WC, Block MS, Pease LR, Celis E. Direct cross-priming by th lymphocytes generates memory cytotoxic T cell responses. J Immunol. 2005 Apr 1; 174: (7)3967-77.
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  76. Davila E, Kennedy R, Celis E. Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade. Cancer Res. 2003 Jun 15; 63(12):3281-8.
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  77. Lu J, Giuntoli RL 2nd, Omiya R, Kobayashi H, Kennedy R, Celis E. Interleukin 15 promotes antigen-independent in vitro expansion and long-term survival of antitumor cytotoxic T lymphocytes. Clin Cancer Res. 2002 Dec; 8(12):3877-84.
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  78. Linardakis E, Bateman A, Phan V, Ahmed A, Gough M, Olivier K, Kennedy R, Errington F, Harrington KJ, Melcher A, Vile R. Enhancing the efficacy of a weak allogeneic melanoma vaccine by viral fusogenic membrane glycoprotein-mediated tumor cell-tumor cell fusion. Cancer Res. 2002 Oct 1; 62(19):5495-504.
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  79. Giuntoli RL, Lu J, Kobayashi H, Kennedy R, Celis E. Direct costimulation of tumor-reactive CTL by helper T cells potentiate their proliferation, survival, and effector function. Clin Cancer Res. 2002 Mar; 8(3):922-31.
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  80. Kobayashi H, Kennedy R, Lu J, Davila E, Celis E. MHC-binding peptides as immunotherapeutics for cancer. Immunol Invest. 2000 May; 29(2):105-10.
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  81. Borson ND, Strausbauch MA, Kennedy RB, Oda RP, Landers JP, Wettstein PJ. Temporal sequence of transcription of perforin, Fas ligand, and tumor necrosis factor-alpha genes in rejecting skin allografts. Transplantation. 1999 Mar 15; 67(5):672-80.
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