Publications

  1. Wang L, Chen J, Wang C, Uuskula-Reimand L, Chen K, Medina-Rivera A, Young EJ, Zimmermann MT, Yan H, Sun Z, Zhang Y, Wu ST, Huang H, Wilson MD, Kocher JP, Li W. MACE: model based analysis of ChIP-exo. Nucleic Acids Res. 2014 Sep 23.
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  2. Wang L, Xiong H, Wu F, Zhang Y, Wang J, Zhao L, Guo X, Chang LJ, Zhang Y, You MJ, Koochekpour S, Saleem M, Huang H, Lu J, Deng Y. Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth. Cell Rep. 2014 Sep 11; 8(5):1461-74. Epub 2014 Aug 28.
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  3. Lu J, Lonergan PE, Nacusi LP, Wang L, Schmidt LJ, Sun Z, Van der Steen T, Boorjian SA, Kosari F, Vasmatzis G, Klee GG, Balk SP, Huang H, Wang C, Tindall DJ. The cistrome and gene signature of androgen receptor splice variants in castration-resistant prostate cancer cells. J Urol. 2014 Aug 14.
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  4. Ding L, Chen S, Liu P, Pan Y, Zhong J, Regan KM, Wang L, Yu C, Rizzardi A, Cheng L, Zhang J, Schmechel SC, Cheville JC, Van Deursen J, Tindall DJ, Huang H. CBP loss cooperates with PTEN haploinsufficiency to drive prostate cancer: implications for epigenetic therapy. Cancer Res. 2014 Apr 1; 74(7):2050-61. Epub 2014 Feb 03.
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  5. Zhao H, Sun Z, Wang J, Huang H, Kocher JP, Wang L. CrossMap: a versatile tool for coordinate conversion between genome assemblies. Bioinformatics. 2014 Apr 1; 30(7):1006-7. Epub 2013 Dec 18.
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  6. Zhong J, Ding L, Bohrer LR, Pan Y, Liu P, Zhang J, Sebo TJ, Karnes RJ, Tindall DJ, van Deursen J, Huang H. p300 acetyltransferase regulates androgen receptor degradation and PTEN-deficient prostate tumorigenesis. Cancer Res. 2014 Mar 15; 74(6):1870-80. Epub 2014 Jan 30.
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  7. An J, Wang C, Deng Y, Yu L, Huang H. Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants. Cell Rep. 2014 Feb 27; 6(4):657-69. Epub 2014 Feb 06.
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  8. Zhang P, Gao K, Tang Y, Jin X, An J, Yu H, Wang H, Zhang Y, Wang D, Huang H, Yu L, Wang C. Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants. Hum Mutat. 2014; 35(9):1142-51.
  9. Zhao Y, Tindall DJ, Huang H. Modulation of Androgen Receptor by FOXA1 and FOXO1 Factors in Prostate Cancer. Int J Biol Sci. 2014; 10(6):614-9. Epub 2014 Jun 05.
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  10. Huang H. Scaffold attachment factor B1: an intrinsic inhibitor of androgen receptor downregulated in prostate cancer. Asian J Androl. 2013 Nov; 15(6):703-4. Epub 2013 Sep 30.
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  11. Bohrer LR, Liu P, Zhong J, Pan Y, Angstman J, Brand LJ, Dehm SM, Huang H. FOXO1 binds to the TAU5 motif and inhibits constitutively active androgen receptor splice variants. Prostate. 2013 Jul; 73(10):1017-27. Epub 2013 Feb 06.
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  12. Wang L, Zeng X, Chen S, Ding L, Zhong J, Zhao JC, Wang L, Sarver A, Koller A, Zhi J, Ma Y, Yu J, Chen J, Huang H. BRCA1 is a negative modulator of the PRC2 complex. EMBO J. 2013 May 29; 32(11):1584-97. Epub 2013 Apr 26.
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  13. Xiao Q, Qu K, Wang C, Kong Y, Liu C, Jiang D, Saiyin H, Jia F, Ni C, Chen T, Zhang Y, Zhang P, Qin W, Sun Q, Wang H, Yi Q, Liu J, Huang H, Yu L. HDGF-related protein-3 is required for anchorage-independent survival and chemoresistance in hepatocellular carcinomas. Gut. 2013 Mar; 62(3):440-51. Epub 2012 Apr 05.
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  14. Yang Y, Wang C, Zhang P, Gao K, Wang D, Yu H, Zhang T, Jiang S, Hexige S, Hong Z, Yasui A, Liu JO, Huang H, Yu L. Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis. J Biol Chem. 2013 Jan 4; 288(1):529-39. Epub 2012 Nov 13.
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  15. van der Steen T, Tindall DJ, Huang H. Posttranslational modification of the androgen receptor in prostate cancer. Int J Mol Sci. 2013; 14(7):14833-59. Epub 2013 Jul 16.
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  16. Mao J, Yu H, Wang C, Sun L, Jiang W, Zhang P, Xiao Q, Han D, Saiyin H, Zhu J, Chen T, Roberts LR, Huang H, Yu L. Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomas. Carcinogenesis. 2012 Dec; 33(12):2568-77. Epub 2012 Sep 12.
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  17. Jiang J, Pan Y, Regan KM, Wu C, Zhang X, Tindall DJ, Huang H. Androgens repress expression of the F-box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells. Prostate. 2012 Feb 1; 72(2):225-32. Epub 2011 May 31.
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  18. Huang H, Tindall DJ. Regulation of FOXO protein stability via ubiquitination and proteasome degradation. Biochim Biophys Acta. 2011 Nov; 1813(11):1961-4. Epub 2011 Jan 14.
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  19. Lu H, Liu P, Pan Y, Huang H. Inhibition of cyclin-dependent kinase phosphorylation of FOXO1 and prostate cancer cell growth by a peptide derived from FOXO1. Neoplasia. 2011 Sep; 13(9):854-63.
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  20. Lu H, Huang H. FOXO1: a potential target for human diseases. Curr Drug Targets. 2011 Aug; 12(9):1235-44.
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  21. Zhang H, Pan Y, Zheng L, Choe C, Lindgren B, Jensen ED, Westendorf JJ, Cheng L, Huang H. FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion. Cancer Res. 2011 May 1; 71(9):3257-67. Epub 2011 Apr 19.
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  22. Zeng X, Chen S, Huang H. Phosphorylation of EZH2 by CDK1 and CDK2: a possible regulatory mechanism of transmission of the H3K27me3 epigenetic mark through cell divisions. Cell Cycle. 2011 Feb 15; 10(4):579-83.
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  23. Chen S, Bohrer LR, Rai AN, Pan Y, Gan L, Zhou X, Bagchi A, Simon JA, Huang H. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. Nat Cell Biol. 2010 Nov; 12(11):1108-14. Epub 2010 Oct 10.
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  24. Bohrer LR, Chen S, Hallstrom TC, Huang H. Androgens suppress EZH2 expression via retinoblastoma (RB) and p130-dependent pathways: a potential mechanism of androgen-refractory progression of prostate cancer. Endocrinology. 2010 Nov; 151(11):5136-45. Epub 2010 Sep 29.
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  25. Jiang J, Huang H. Targeting the Androgen Receptor by Taxol in Castration-Resistant Prostate Cancer. Mol Cell Pharmacol. 2010 Jan 1; 2(1):1-5.
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  26. Wang D, Montgomery RB, Schmidt LJ, Mostaghel EA, Huang H, Nelson PS, Tindall DJ. Reduced tumor necrosis factor receptor-associated death domain expression is associated with prostate cancer progression. Cancer Res. 2009 Dec 15; 69(24):9448-56.
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  27. Gan L, Chen S, Wang Y, Watahiki A, Bohrer L, Sun Z, Wang Y, Huang H. Inhibition of the androgen receptor as a novel mechanism of taxol chemotherapy in prostate cancer. Cancer Res. 2009 Nov 1; 69(21):8386-94. Epub 2009 Oct 13.
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  28. Gan L, Liu P, Lu H, Chen S, Yang J, McCarthy JB, Knudsen KE, Huang H. Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis. Cell Death Differ. 2009 Oct; 16(10):1408-17. Epub 2009 Jul 03.
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  29. Liu P, Li S, Gan L, Kao TP, Huang H. A transcription-independent function of FOXO1 in inhibition of androgen-independent activation of the androgen receptor in prostate cancer cells. Cancer Res. 2008 Dec 15; 68(24):10290-9.
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  30. Liu P, Kao TP, Huang H. CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor. Oncogene. 2008 Aug 7; 27(34):4733-44. Epub 2008 Apr 14.
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  31. Huang H, Tindall DJ. Dynamic FoxO transcription factors. J Cell Sci. 2007 Aug 1; 120(Pt 15):2479-87.
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  32. Huang H, Tindall DJ. CDK2 and FOXO1: a fork in the road for cell fate decisions. Cell Cycle. 2007 Apr 15; 6(8):902-6. Epub 2007 Apr 05.
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  33. Huang H, Regan KM, Lou Z, Chen J, Tindall DJ. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science. 2006 Oct 13; 314(5797):294-7.
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  34. Huang H, Tindall DJ. FOXO factors: a matter of life and death. Future Oncol. 2006 Feb; 2(1):83-9.
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  35. Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen JM, Tindall DJ. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5):1649-54. Epub 2005 Jan 24.
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  36. Huang H, Muddiman DC, Tindall DJ. Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells. J Biol Chem. 2004 Apr 2; 279(14):13866-77. Epub 2004 Jan 15.
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  37. Huang H, Zegarra-Moro OL, Benson D, Tindall DJ. Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells. Oncogene. 2004 Mar 18; 23(12):2161-76.
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  38. Santos AF, Huang H, Tindall DJ. The androgen receptor and its clinical relevance in prostate cancer. Steroid. 2004; 69:79-85.
  39. Deocampo ND, Huang H, Tindall DJ. The role of PTEN in the progression and survival of prostate cancer. Minerva Endocrinol. 2003 Jun; 28(2):145-53.
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  40. Zegarra-Moro OL, Schmidt LJ, Huang H, Tindall DJ. Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells. Cancer Res. 2002 Feb 15; 62(4):1008-13.
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  41. Debes JD, Schmidt LJ, Huang H, Tindall DJ. p300 mediates interleukin-6-dependent transactivation of the androgen receptor. Cancer Research. 2002; 62:5632-5636.
  42. Huang H, Tindall DJ. The role of the androgen receptor in prostate cancer. Crit Rev Eukaryot Gene Expr. 2002; 12(3):193-207.
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  43. Grossmann ME, Huang H, Tindall DJ. Androgen receptor signaling in androgen-refractory prostate cancer. J Natl Cancer Inst. 2001 Nov 21; 93(22):1687-97.
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  44. Murillo H, Huang H, Schmidt LJ, Smith DI, Tindall DJ. Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinology. 2001 Nov; 142(11):4795-805.
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  45. Huang H, Cheville JC, Pan Y, Roche PC, Schmidt LJ, Tindall DJ. PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression. J Biol Chem. 2001 Oct 19; 276(42):38830-6. Epub 2001 Aug 08.
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  46. Shridhar V, Bible KC, Staub J, Avula R, Lee YK, Kalli K, Huang H, Hartmann LC, Kaufmann SH, Smith DI. Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer. Cancer Res. 2001 May 15; 61(10):4258-65.
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  47. Zhang JS, Wang L, Huang H, Nelson M, Smith DI. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. Genes Chromosomes Cancer. 2001 Feb; 30(2):123-35.
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  48. Huang H, Reed CP, Zhang JS, Shridhar V, Wang L, Smith DI. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. Cancer Res. 1999 Jun 15; 59(12):2981-8.
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  49. Wang L, Darling J, Zhang JS, Huang H, Liu W, Smith DI. Allele-specific late replication and fragility of the most active common fragile site, FRA3B. Hum Mol Genet. 1999 Mar; 8(3):431-7.
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  50. Shi Q, Shan X, Zhang J, Zhang X, Chen Y, Deng X, Huang H, Yu L, Zhao S, Zheng Q, Adler I. [A DNA probe suitable for the detection of chromosome 21 copy number in human interphase nuclei by fluorescence in situ hybridization]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1999 Feb 10; 16(1):36-40.
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  51. Huang H, Reed CP, Mordi A, Lomberk G, Wang L, Shridhar V, Hartmann L, Jenkins R, Smith DI. Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer. Genes Chromosomes Cancer. 1999 Jan; 24(1):48-55.
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  52. Shi QH, Zhang JX, Pan SJ, Zhang XR, Chen YF, Shan XN, Huang HJ, Yu L, Zhao SY, Zheng QP, Adler ID. [Studies of meiotic origin of the extra chromosome 21 in Down syndromes detected by using (GT)n polymorphic DNA markers]. Yi Chuan Xue Bao. 1998 Dec; 25(6):478-84.
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  53. Huang H, Qian J, Proffit J, Wilber K, Jenkins R, Smith DI. FRA7G extends over a broad region: coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites. Oncogene. 1998 May 7; 16(18):2311-9.
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  54. Jenkins RB, Qian J, Lee HK, Huang H, Hirasawa K, Bostwick DG, Proffitt J, Wilber K, Lieber MM, Liu W, Smith DI. A molecular cytogenetic analysis of 7q31 in prostate cancer. Cancer Res. 1998 Feb 15; 58(4):759-66.
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  55. Huang H, Qian C, Jenkins RB, Smith DI. Fish mapping of YAC clones at human chromosomal band 7q31.2: identification of YACS spanning FRA7G within the common region of LOH in breast and prostate cancer. Genes Chromosomes Cancer. 1998 Feb; 21(2):152-9.
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  56. Smith DI, Huang H, Wang L. Common fragile sites and cancer (review). Int J Oncol. 1998 Jan; 12(1):187-96.
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  57. Huang H, Zhang X, Chen Y. Chromosomal homologies between Hom sapiens and Macaca mulatta and implications for human chromosome evolution. Acta Zoologica Sinica. 1998; 50:187-196.
  58. Mai M, Huang H, Reed CP, Qian C, Smith JS, Alderete B, Jenkins RB, Smith DI, Liu W. Genomic organization of p73 and mutation analysis of this gene in oligodendrogliomas with chromosome 1p deletions. Genomics. 1998; 51:359-63.
  59. Pan Y, Xue Y, Huang H, Chen Y, Xia X, Guo Y, Xie X, Ran C. The application of chromosome painting technique to study hematological malignancies. Chinese Journal of Medical Genetics. 1997; 14:203-206.
  60. Pan S, Zhang X, Huang H, Chen Y, Huang G. Study of human, Macaca mulatta, Macaca fasicularis chromosome using fluorescence in situ hybridization (FISH). Hereditas. 1997; 19:9-12.
  61. Han S, Yu L, Huang H, Xu L, Li X, Zhao S. A new method of isolating YAC DNA used as probe for FISH. High Technology Letters. 1996; 6:38-41.
  62. Zhang X, Huang H, Chen Y, Pan Y, Xue Y, Guo Y, Xie X, Ran C. Detection of rare ph translocation in chronic myelogenous leukemia by chromosome painting. Chinese Journal of Medical Genetics. 1996; 13:337-340.
  63. Huang H, Zhang X, Chen Y, Cui Y. [A study on complicated chromosome translocation by fluorescence in situ hybridization (FISH) of G-banded chromosomes]. Yi Chuan Xue Bao. 1996; 23(5):338-42.
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  64. Huang H, Zhang X, Xue M, Chen Y, Xu Z, Wang X. A de novo chromosome aberration in uterine leiomyomas detected by fluorescence in situ hybridization. Chinese Journal of Medical Genetics. 1995; 12:237-238.
  65. Huang H, Zhang X, Chen Y. [Studies of the homology of chromosomes between human being and rhesus monkey with chromosomal in situ suppression hybridization]. Yi Chuan Xue Bao. 1993; 20(3):193-200.
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  66. Huang H, Chen Y. Nonradioactive chromosomal in situ hybridization and its applications. Foreign Medicine. 1993; 16:70-75.