Publications

  1. Bell MP, Renner DN, Johnson AJ, Pavelko KD. A CD8 T-cell epitope variant enhances immune targeting to a recombinant picornavirus vaccine antigen. Viral Immunol. 2014 Sep; 27(7):361-6. Epub 2014 Jul 15.
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  2. Johnson HL, Jin F, Pirko I, Johnson AJ. Theiler's murine encephalomyelitis virus as an experimental model system to study the mechanism of blood-brain barrier disruption. J Neurovirol. 2014 Apr; 20(2):107-12. Epub 2013 Jul 16.
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  3. Johnson HL, Willenbring RC, Jin F, Manhart WA, LaFrance SJ, Pirko I, Johnson AJ. Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption. PLoS One. 2014; 9(10):e111401. Epub 2014 Oct 22.
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  4. Bell MP, Renner DN, Johnson AJ, Pavelko KD. An elite controller of picornavirus infection targets an epitope that is resistant to immune escape. PLoS One. 2014; 9(4):e94332. Epub 2014 Apr 07.
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  5. Johnson HL, Hanson LM, Chen Y, Bieber AJ, Buono RJ, Ferraro TN, Pirko I, Johnson AJ. Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption. BMC Genomics. 2013; 14:678. Epub 2013 Oct 03.
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  6. Johnson HL, Chen Y, Jin F, Hanson LM, Gamez JD, Pirko I, Johnson AJ. CD8 T cell-initiated blood-brain barrier disruption is independent of neutrophil support. J Immunol. 2012 Aug 15; 189(4):1937-45. Epub 2012 Jul 06.
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  7. Pavelko KD, Mendez-Fernandez Y, Bell MP, Hansen MJ, Johnson AJ, David CS, Rodriguez M, Pease LR. Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity. PLoS Pathog. 2012 Feb; 8(2):e1002541. Epub 2012 Feb 23.
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  8. Loftspring MC, Johnson HL, Johnson AJ, Clark JF. Depletion of GR-1-positive cells is associated with reduced neutrophil inflammation and astrocyte reactivity after experimental intracerebral hemorrhage. Translational Stroke Research. 2012; 3(Suppl 1):147-54.
  9. Johnson HL, Chen Y, Suidan GL, McDole JR, Lohrey AK, Hanson LM, Jin F, Pirko I, Johnson AJ. A hematopoietic contribution to microhemorrhage formation during antiviral CD8 T cell-initiated blood-brain barrier disruption. J Neuroinflammation. 2012; 9:60. Epub 2012 Mar 27.
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  10. Pirko I, Chen Y, Lohrey AK, McDole J, Gamez JD, Allen KS, Pavelko KD, Lindquist DM, Dunn RS, Macura SI, Johnson AJ. Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation. PLoS One. 2012; 7(2):e31459. Epub 2012 Feb 13.
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  11. Pirko I, Cardin R, Chen Y, Lohrey AK, Lindquist DM, Dunn RS, Zivadinov R, Johnson AJ. CMV infection attenuates the disease course in a murine model of multiple sclerosis. PLoS One. 2012; 7(2):e32767. Epub 2012 Feb 29.
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  12. Suidan GL, Dickerson JW, Johnson HL, Chan TW, Pavelko KD, Pirko I, Seroogy KB, Johnson AJ. Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability. J Neuroinflammation. 2012; 9:218. Epub 2012 Sep 18.
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  13. Suidan GL, Dickerson JW, Johnson HL, Chan TW, Pavelko KD, Pirko I, Seroogy KB, Johnson AJ. Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability. J Neuroinflammation. 2012; 9:218. Epub 2012 Sep 18.
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  14. Marchi N, Johnson AJ, Puvenna V, Johnson HL, Tierney W, Ghosh C, Cucullo L, Fabene PF, Janigro D. Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures. Epilepsia. 2011 Sep; 52(9):1627-34. Epub 2011 May 31
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  15. Loftspring MC, Johnson HL, Feng R, Johnson AJ, Clark JF. Unconjugated bilirubin contributes to early inflammation and edema after intracerebral hemorrhage. J Cereb Blood Flow Metab. 2011 Apr; 31(4):1133-42. Epub 2010 Nov 24.
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  16. Denic A, Johnson AJ, Bieber AJ, Warrington AE, Rodriguez M, Pirko I. The relevance of animal models in multiple sclerosis research. Pathophysiology. 2011 Feb; 18(1):21-9.
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  17. Pirko I, Johnson AJ, Chen Y, Lindquist DM, Lohrey AK, Ying J, Dunn RS. Brain atrophy correlates with functional outcome in a murine model of multiple sclerosis. Neuroimage. 2011 Jan 15; 54(2):802-6. Epub 2010 Sep 15.
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  18. McDole JR, Danzer SC, Pun RY, Chen Y, Johnson HL, Pirko I, Johnson AJ. Rapid formation of extended processes and engagement of Theiler's virus-infected neurons by CNS-infiltrating CD8 T cells. Am J Pathol. 2010 Oct; 177(4):1823-33. Epub 2010 Sep 02.
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  19. Suidan GL, Dickerson JW, Chen Y, McDole JR, Tripathi P, Pirko I, Seroogy KB, Johnson AJ. CD8 T cell-initiated vascular endothelial growth factor expression promotes central nervous system vascular permeability under neuroinflammatory conditions. J Immunol. 2010 Jan 15; 184(2):1031-40. Epub 2009 Dec 11.
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  20. Pirko I, Johnson AJ, Lohrey AK, Chen Y, Ying J. Deep gray matter T2 hypointensity correlates with disability in a murine model of MS. J Neurol Sci. 2009 Jul 15; 282(1-2):34-8. Epub 2009 Jan 21.
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  21. Loftspring MC, McDole J, Lu A, Clark JF, Johnson AJ. Intracerebral hemorrhage leads to infiltration of several leukocyte populations with concomitant pathophysiological changes. J Cereb Blood Flow Metab. 2009 Jan; 29(1):137-43. Epub 2008 Oct 01.
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  22. McDole J, Suidan G, Boespflug E, Cheng J, Chen Y, Pirko I, Johnson A. A translatable molecular approach to determining CD8 T-cell epitopes in TMEV infection. Hum Immunol. 2008 Nov; 69(11):805-10. Epub 2008 Sep 24
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  23. Pirko I, Nolan TK, Holland SK, Johnson AJ. Multiple sclerosis: pathogenesis and MR imaging features of T1 hypointensities in a [corrected] murine model. Radiology. 2008 Mar; 246(3):790-5.
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  24. Pirko I, Suidan GL, Rodriguez M, Johnson AJ. Acute hemorrhagic demyelination in a murine model of multiple sclerosis. J Neuroinflammation. 2008; 5:31. Epub 2008 Jul 07.
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  25. Suidan GL, Mcdole JR, Chen Y, Pirko I, Johnson AJ. Induction of blood brain barrier tight junction protein alterations by CD8 T cells. PLoS One. 2008; 3(8):e3037. Epub 2008 Aug 22.
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  26. Howe CL, Ure D, Adelson JD, LaFrance-Corey R, Johnson A, Rodriguez M. CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination. J Neuroimmunol. 2007 Aug; 188(1-2):13-21. Epub 2007 May 09.
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  27. Johnson AJ, Suidan GL, McDole J, Pirko I. The CD8 T cell in multiple sclerosis: suppressor cell or mediator of neuropathology? Int Rev Neurobiol. 2007; 79:73-97.
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  28. Zivadinov R, Nasuelli D, Tommasi MA, Serafin M, Bratina A, Ukmar M, Pirko I, Johnson AJ, Furlan C, Pozzi-Mucelli RS, Monti-Bragadin L, Grop A, Zambon M, Antonello RM, Cazzato G, Zorzon M. Positivity of cytomegalovirus antibodies predicts a better clinical and radiological outcome in multiple sclerosis patients. Neurol Res. 2006 Apr; 28(3):262-9.
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  29. McDole J, Johnson AJ, Pirko I. The role of CD8+ T-cells in lesion formation and axonal dysfunction in multiple sclerosis. Neurol Res. 2006 Apr; 28(3):256-61.
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  30. Suidan GL, Pirko I, Johnson AJ. A potential role for CD8+ T-cells as regulators of CNS vascular permeability. Neurol Res. 2006 Apr; 28(3):250-5.
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  31. Johnson AJ, Mendez-Fernandez Y, Moyer AM, Sloma CR, Pirko I, Block MS, Rodriguez M, Pease LR. Antigen-specific CD8+ T cells mediate a peptide-induced fatal syndrome. J Immunol. 2005 Jun 1; 174(11):6854-62.
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  32. Pirko I, Fricke ST, Johnson AJ, Rodriguez M, Macura SI. Magnetic resonance imaging, microscopy, and spectroscopy of the central nervous system in experimental animals. NeuroRx. 2005 Apr; 2(2):250-64.
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  33. Pirko I, Ciric B, Gamez J, Bieber AJ, Warrington AE, Johnson AJ, Hanson DP, Pease LR, Macura SI, Rodriguez M. A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS. FASEB J. 2004 Oct; 18(13):1577-9. Epub 2004 Aug 19.
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  34. Xu R, Johnson AJ, Liggitt D, Bevan MJ. Cellular and humoral immunity against vaccinia virus infection of mice. J Immunol. 2004 May 15; 172(10):6265-71.
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  35. Pirko I, Johnson A, Ciric B, Gamez J, Macura SI, Pease LR, Rodriguez M. In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies. FASEB J. 2004 Jan; 18(1):179-82. Epub 2003 Nov 20
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  36. Pirko I, Gamez J, Johnson AJ, Macura SI, Rodriguez M. Dynamics of RI lesion development in an animal model of viral induced acute progressive CNS demyelination. Neuroimage. 2004; 21(2):576-82.
  37. Pirko I, Johnson AJ, Gamez J, Macura, SI, Rodriguez M. Disappearing "T1 black holes" in an animal model of multiple sclerosis. Front Biosci. 2004; 9:1222-7.
  38. Mendez-Fernandez YV, Johnson AJ, Rodriguez M, Pease LR. Clearance of Theiler's virus infection depends on the ability to generate a CD8(+) T cell response against a single immunodominant viral peptide. Eur J Immunol. 2003 Sep; 33(9):2501-10.
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  39. Pirko I, Ciric B, Johnson AJ, Gamez J, Rodriguez M, Macura S. Magnetic resonance imaging of immune cells in inflammation of central nervous system. Croat Med J. 2003 Aug; 44(4):463-8.
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  40. Zoecklein LJ, Pavelko KD, Gamez J, Papke L, McGavern DB, Ure DR, Njenga MK, Johnson AJ, Nakane S, Rodriguez M. Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus. Brain Pathol. 2003 Jul; 13(3):291-308.
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  41. Pavelko KD, Howe CL, Drescher KM, Gamez JD, Johnson AJ, Wei T, Ransohoff RM, Rodriguez M. Interleukin-6 protects anterior horn neurons from lethal virus-induced injury. J Neurosci. 2003 Jan 15; 23(2):481-92.
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  42. Mendez-Fernandez YV, Pogulis RP, Block MS, Johnson AJ, Kuhns ST, Allen KS, Hansen MJ, Pease LR. Enhanced binding of low-affinity antibodies interacting simultaneously with targeted cell surface molecules and Fc receptor. Tissue Antigens. 2002 Dec; 60(6):515-25.
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  43. Wilcox RA, Flies DB, Wang H, Tamada K, Johnson AJ, Pease LR, Rodriguez M, Guo YJ, Chen LP. Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy. Cancer Res. 2002 Aug 1; 62(15):4413-8.
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  44. Lin XQ, Njenga MK, Johnson AJ, Pavelko KD, David CS, Pease LR, Rodriguez M. Transgenic expression of Theiler's murine encephalomyelitis virus genes in H-2(b) mice inhibits resistance to virus-induced demyelination. J Virol. 2002 Aug; 76(15):7799-811.
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  45. Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval AI, Strome SE, Pease LR, Chen L. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J Clin Invest. 2002 Mar; 109(5):651-9.
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  46. Johnson AJ, Upshaw J, Pavelko KD, Rodriguez M, Pease LR. Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. FASEB J. 2001 Dec; 15(14):2760-2. Epub 2001 Oct 15.
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  47. Block MS, Johnson AJ, Mendez-Fernandez Y, Pease LR. Monomeric class I molecules mediate TCR/CD3 epsilon/CD8 interaction on the surface of T cells. J Immunol. 2001 Jul 15; 167(2):821-6.
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  48. Zhang X, Brewer L, Walcheck B, Johnson A, Pease LR, Njenga MK. Theiler's virus-infected L-selectin-deficient mice have decreased infiltration of CD8(+) T lymphocytes in central nervous system but clear the virus. J Neuroimmunol. 2001 Jun 1; 116(2):178-87.
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  49. Kuhns ST, Tallquist MD, Johnson AJ, Mendez-Fernandez Y, Pease LR. T cell receptor interactions with class I heavy-chain influence T cell selection. Proc Natl Acad Sci U S A. 2000 Jan 18; 97(2):756-60.
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  50. Johnson AJ, Njenga MK, Hansen MJ, Kuhns ST, Chen L, Rodriguez M, Pease LR. Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28. J Virol. 1999 May; 73(5):3702-8.
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  51. Gacy AM, Goellner GM, Spiro C, Chen X, Gupta G, Bradbury EM, Dyer RB, Mikesell MJ, Yao JZ, Johnson AJ, Richter A, Melancon SB, McMurray CT. GAA instability in Friedreich's Ataxia shares a common, DNA-directed and intraallelic mechanism with other trinucleotide diseases. Mol Cell. 1998 Mar; 1(4):583-93.
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  52. Johnson AJ, Johnson SJ, Karim MR. In vitro synergistic effects of six plant extracts against HSV-1 and HSV-2. Proceedings of the Tenth National Conference of Undergraduate Research. 1996; 3:1578-82.