Publications

  1. Escande C, Nin V, Pirtskhalava T, Chini CC, Tchkonia T, Kirkland JL, Chini EN. Deleted in Breast Cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype. Diabetes. 2014 Jul 22.
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  2. Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN. Deleted in Breast Cancer 1 regulates cellular senescence during obesity. Aging Cell. 2014 Jul 03.
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  3. Nin V, Chini CC, Escande C, Capellini V, Chini EN. Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis. J Biol Chem. 2014 Feb 28; 289(9):5518-27. Epub 2014 Jan 10.
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  4. Chini CC, Guerrico AM, Nin V, Camacho-Pereira J, Escande C, Barbosa MT, Chini EN. Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors. Clin Cancer Res. 2014 Jan 1; 20(1):120-30. Epub 2013 Sep 11.
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  5. Calliari A, Bobba N, Escande C, Chini EN. Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. Exp Neurol. 2014 Jan; 251:91-100. Epub 2013 Nov 16
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  6. Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V. Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014; 2:13. Epub 2014 Aug 18.
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  7. Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R. Kruppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. J Biol Chem. 2013 Jun 14; 288(24):17745-58. Epub 2013 Apr 15.
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  8. Chini CC, Escande C, Nin V, Chini EN. DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbalpha. Biochem J. 2013 May 1; 451(3):453-61.
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  9. Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 2013 Apr; 62(4):1084-93. Epub 2012 Nov 19.
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  10. Chini EN, Chini CC, Nin V, Escande C. Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer. Biosci Rep. 2013; 33(4). Epub 2013 Aug 23.
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  11. Nin V, Escande C, Chini CC, Giri S, Camacho-Pereira J, Matalonga J, Lou Z, Chini EN. Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. J Biol Chem. 2012 Jul 6; 287(28):23489-501. Epub 2012 May 02.
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  12. Sahar S, Nin V, Barbosa MT, Chini EN, Sassone-Corsi P. Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation. Aging (Albany NY). 2011 Aug; 3(8):794-802.
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  13. Aksoy P, Brown MJ, Chini EN. HMG-CoA reductase inhibitors decrease hyperglycemia on animal model of Systemic inflammatory response Syndrome (SIRS). Journal of Anesthesia and Clinical Research. 2011; 2(9):165.
  14. Chini CC, Escande C, Nin V, Chini EN. HDAC3 is negatively regulated by the nuclear protein DBC1. J Biol Chem. 2010 Dec 24; 285(52):40830-7. Epub 2010 Oct 28.
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  15. Novak CM, Escande C, Burghardt PR, Zhang M, Barbosa MT, Chini EN, Britton SL, Koch LG, Akil H, Levine JA. Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity. Horm Behav. 2010 Aug; 58(3):355-67. Epub 2010 Mar 27.
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  16. Hartman WR, Pelleymounter LL, Moon I, Kalari K, Liu M, Wu TY, Escande C, Nin V, Chini EN, Weinshilboum RM. CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system. Leuk Lymphoma. 2010 Jul; 51(7):1315-25.
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  17. Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest. 2010 Feb; 120(2):545-58. Epub 2010 Jan 11.
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  18. Novak CM, Escande C, Gerber SM, Chini EN, Zhang M, Britton SL, Koch LG, Levine JA. Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK. PLoS One. 2009; 4(6):e5869. Epub 2009 Jun 12.
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  19. Chini EN. CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions. Curr Pharm Des. 2009; 15(1):57-63.
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  20. Nagamune K, Hicks LM, Fux B, Brossier F, Chini EN, Sibley LD. Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii. Nature. 2008 Jan 10; 451(7175):207-10.
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  21. Nagamune K, Moreno SN, Chini EN, Sibley LD. Calcium regulation and signaling in apicomplexan parasites. Subcell Biochem. 2008; 47:70-81.
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  22. Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J. 2007 Nov; 21(13):3629-39. Epub 2007 Jun 21.
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  23. Perkins WJ, Taniguchi M, Warner DO, Chini EN, Jones KA. Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L84-95. Epub 2007 Mar 23.
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  24. Soares S, Thompson M, White T, Isbell A, Yamasaki M, Prakash Y, Lund FE, Galione A, Chini EN. NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C227-39. Epub 2006 Jun 21.
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  25. Umesh A, Thompson MA, Chini EN, Yip KP, Sham JS. Integrin ligands mobilize Ca2+ from ryanodine receptor-gated stores and lysosome-related acidic organelles in pulmonary arterial smooth muscle cells. J Biol Chem. 2006 Nov 10; 281(45):34312-23. Epub 2006 Sep 09.
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  26. Aksoy P, Escande C, White TA, Thompson M, Soares S, Benech JC, Chini EN. Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38. Biochem Biophys Res Commun. 2006 Oct 13; 349(1):353-9. Epub 2006 Aug 22.
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  27. Kip SN, Smelter M, Iyanoye A, Chini EN, Prakash YS, Pabelick CM, Sieck GC. Agonist-induced cyclic ADP ribose production in airway smooth muscle. Arch Biochem Biophys. 2006 Aug 15; 452(2):102-7. Epub 2006 Jun 30.
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  28. Nakayama T, Penheiter AR, Penheiter SG, Chini EN, Thompson M, Warner DO, Jones KA. Differential effects of volatile anesthetics on M3 muscarinic receptor coupling to the Galphaq heterotrimeric G protein. Anesthesiology. 2006 Aug; 105(2):313-24.
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  29. White TA, Xue A, Chini EN, Thompson M, Sieck GC, Wylam ME. Role of transient receptor potential C3 in TNF-alpha-enhanced calcium influx in human airway myocytes. Am J Respir Cell Mol Biol. 2006 Aug; 35(2):243-51. Epub 2006 Mar 30.
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  30. Aksoy P, White TA, Thompson M, Chini EN. Regulation of intracellular levels of NAD: a novel role for CD38. Biochem Biophys Res Commun. 2006 Jul 14; 345(4):1386-92. Epub 2006 May 15.
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  31. Thompson M, White T, Chini EN. Modulation of store-operated Ca2+ entry by cyclic-ADP-ribose. Braz J Med Biol Res. 2006 Jun; 39(6):739-48. Epub 2006 Jun 02.
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  32. Chini EN, Nagamune K, Wetzel DM, Sibley LD. Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii. Biochem J. 2005 Jul 15; 389(Pt 2):269-77.
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  33. Sen S, Chini EN, Brown MJ. Complications after unintentional intra-arterial injection of drugs: risks, outcomes, and management strategies. Mayo Clin Proc. 2005 Jun; 80(6):783-95.
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  34. Soares SM, Thompson M, Chini EN. Role of the second-messenger cyclic-adenosine 5'-diphosphate-ribose on adrenocorticotropin secretion from pituitary cells. Endocrinology. 2005 May; 146(5):2186-92. Epub 2005 Feb 17.
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  35. Burrow B, Burkle C, Warner DO, Chini EN. Postoperative outcome of patients with narcolepsy. A retrospective analysis. J Clin Anesth. 2005 Feb; 17(1):21-5.
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  36. Chini EN, Brown MJ, Farrell MA, Charboneau JW. Hypertensive crisis in a patient undergoing percutaneous radiofrequency ablation of an adrenal mass under general anesthesia. Anesth Analg. 2004 Dec; 99(6):1867-9.
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  37. Thompson M, Barata da Silva H, Zielinska W, White TA, Bailey JP, Lund FE, Sieck GC, Chini EN. Role of CD38 in myometrial Ca2+ transients: modulation by progesterone. Am J Physiol Endocrinol Metab. 2004 Dec; 287(6):E1142-8. Epub 2004 Aug 31
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  38. Zielinska W, Barata H, Chini EN. Metabolism of cyclic ADP-ribose: Zinc is an endogenous modulator of the cyclase/NAD glycohydrolase ratio of a CD38-like enzyme from human seminal fluid. Life Sci. 2004 Feb 20; 74(14):1781-90.
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  39. Barata H, Thompson M, Zielinska W, Han YS, Mantilla CB, Prakash YS, Feitoza S, Sieck G, Chini EN. The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells. Endocrinology. 2004 Feb; 145(2):881-9. Epub 2003 Oct 16.
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  40. Chini EN. To be or not to be ... nicotinic acid adenine dinucleotide phosphate (NAADP): a new intracellular second messenger? Biol Res. 2004; 37(4):559-63.
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  41. Chini EN, Chini CC, Barata da Silva H, Zielinska W. The cyclic-ADP-ribose signaling pathway in human myometrium. Arch Biochem Biophys. 2002 Nov 15; 407(2):152-9.
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  42. Chini EN, Keller TF, Prakash YS, Pabelick CM, Sieck G. Effect of halothane on cADP-ribose-induced Ca(2+) release system in tracheal smooth muscle. Anesthesiology. 2002 Oct; 97(4):1022-4.
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  43. Chini EN, De Toledo FG. Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger? Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1191-8.
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  44. Chini EN. Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release. Braz J Med Biol Res. 2002 May; 35(5):543-7.
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  45. Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H. CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues. Biochem J. 2002 Feb 15; 362(Pt 1):125-30.
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  46. Chini EN. Selected contribution: effect of volatile anesthetics on cADP-ribose-induced Ca(2+) release system. J Appl Physiol (1985). 2001 Jul; 91(1):516-21; discussion 504-5.
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  47. Yusufi AN, Cheng J, Thompson MA, Chini EN, Grande JP. Nicotinic acid-adenine dinucleotide phosphate (NAADP) elicits specific microsomal Ca2+ release from mammalian cells. Biochem J. 2001 Feb 1; 353(Pt 3):531-6.
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  48. Cheng J, Yusufi AN, Thompson MA, Chini EN, Grande JP. Nicotinic acid adenine dinucleotide phosphate: a new Ca2+ releasing agent in kidney. J Am Soc Nephrol. 2001 Jan; 12(1):54-60.
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  49. de Toledo FG, Cheng J, Liang M, Chini EN, Dousa TP. ADP-Ribosyl cyclase in rat vascular smooth muscle cells: properties and regulation. Circ Res. 2000 Jun 9; 86(11):1153-9.
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  50. Chini EN, Walker H. FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum. Anesthesiology. 2000 May; 92(5):1361-5.
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  51. Liang M, Chini EN, Cheng J, Dousa TP. Synthesis of NAADP and cADPR in mitochondria. Arch Biochem Biophys. 1999 Nov 15; 371(2):317-25.
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  52. Caride AJ, Chini EN, Penniston JT, Dousa TP. Selective decrease of mRNAs encoding plasma membrane calcium pump isoforms 2 and 3 in rat kidney. Kidney Int. 1999 Nov; 56(5):1818-25.
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  53. Chini EN, Dousa TP. Differential effect of glycolytic intermediaries upon cyclic ADP-ribose-, inositol 1',4',5'-trisphosphate-, and nicotinate adenine dinucleotide phosphate-induced Ca(2+) release systems. Arch Biochem Biophys. 1999 Oct 15; 370(2):294-9.
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  54. Chini EN, Liang M, Dousa TP. Differential effect of pH upon cyclic-ADP-ribose and nicotinate-adenine dinucleotide phosphate-induced Ca2+ release systems. Biochem J. 1998 Nov 1; 335 ( Pt 3):499-504.
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  55. Caride AJ, Chini EN, Homma S, Penniston JT, Dousa TP. mRNA encoding four isoforms of the plasma membrane calcium pump and their variants in rat kidney and nephron segments. J Lab Clin Med. 1998 Aug; 132(2):149-56.
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  56. Caride AJ, Chini EN, Homma S, Dousa TP, Penniston JT. mRNAs coding for the calcium-sensing receptor along the rat nephron: effect of a low-phosphate diet. Kidney Blood Press Res. 1998; 21(5):305-9.
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  57. Chini EN, Chini CC, Bolliger C, Jougasaki M, Grande JP, Burnett JC Jr, Dousa TP. Cytoprotective effects of adrenomedullin in glomerular cell injury: central role of cAMP signaling pathway. Kidney Int. 1997 Oct; 52(4):917-25.
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  58. Chini EN, de Toledo FG, Thompson MA, Dousa TP. Effect of estrogen upon cyclic ADP ribose metabolism: beta-estradiol stimulates ADP ribosyl cyclase in rat uterus. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5872-6.
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  59. Chini EN, Klener P Jr, Beers KW, Chini CC, Grande JP, Dousa TP. Cyclic ADP-ribose metabolism in rat kidney: high capacity for synthesis in glomeruli. Kidney Int. 1997 May; 51(5):1500-6.
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  60. Chini CC, Grande JP, Chini EN, Dousa TP. Compartmentalization of cAMP signaling in mesangial cells by phosphodiesterase isozymes PDE3 and PDE4. Regulation of superoxidation and mitogenesis. J Biol Chem. 1997 Apr 11; 272(15):9854-9.
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  61. Chini EN, Thompson MA, Chini CCS, Dousa TP. Cyclic ADP-ribose signaling in sea urchin gametes - metabolism in spermatozoa. Am J Physiol Cell Physiol. 1997 Feb; 272(2):C 416-C 420.
  62. Dousa TP, Chini EN, Beers KW. Adenine nucleotide diphosphates: emerging second messengers acting via intracellular Ca2+ release. Am J Physiol. 1996 Oct; 271(4 Pt 1):C1007-24.
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  63. Chini EN, Dousa TP. Nicotinate-adenine dinucleotide phosphate-induced Ca(2+)-release does not behave as a Ca(2+)-induced Ca(2+)-release system. Biochem J. 1996 Jun 15; 316 ( Pt 3):709-11.
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  64. Beers KW, Thompson MA, Chini EN, Dousa TP. beta-Estradiol inhibits Na+-P(i) cotransport across renal brush border membranes from ovarectomized rats. Biochem Biophys Res Commun. 1996 Apr 16; 221(2):442-5.
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  65. Chini EN, Dousa TP. Palmitoyl-CoA potentiates the Ca2+ release elicited by cyclic ADP-ribose. Am J Physiol. 1996 Feb; 270(2 Pt 1):C530-7.
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  66. Perez-Terzic CM, Chini EN, Shen SS, Dousa TP, Clapham DE. Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs. Biochem J. 1995 Dec 15; 312 ( Pt 3):955-9.
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  67. Caride AJ, Chini EN, Yamaki M, Dousa TP, Penniston JT. Unique localization of mRNA encoding plasma membrane Ca2+ pump isoform 3 in rat thin descending loop of Henle. Am J Physiol. 1995 Nov; 269(5 Pt 2):F681-5.
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  68. Chini EN, Choi E, Grande JP, Burnett JC, Dousa TP. Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway. Biochem Biophys Res Commun. 1995 Oct 24; 215(3):868-73.
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  69. Chini EN, Beers KW, Chini CC, Dousa TP. Specific modulation of cyclic ADP-ribose-induced Ca2+ release by polyamines. Am J Physiol. 1995 Oct; 269(4 Pt 1):C1042-7.
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  70. Matousovic K, Grande JP, Chini CC, Chini EN, Dousa TP. Inhibitors of cyclic nucleotide phosphodiesterase isozymes type-III and type-IV suppress mitogenesis of rat mesangial cells. J Clin Invest. 1995 Jul; 96(1):401-10.
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  71. Beers KW, Chini EN, Dousa TP. All-trans-retinoic acid stimulates synthesis of cyclic ADP-ribose in renal LLC-PK1 cells. J Clin Invest. 1995 May; 95(5):2385-90.
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  72. de Toledo FG, Albuquerque MC, Goulart BH, Chini EN. Different thermostabilities of sarcoplasmic reticulum (Ca2+ + Mg2+)-ATPases from rabbit and trout muscles. Comparative Biochemistry & Physiology. Part C Pharmacology, Toxicology, Endocrinology. 1995 May; 111(1):93-8.
  73. Chini EN, Dousa TP. Enzymatic synthesis and degradation of nicotinate adenine dinucleotide phosphate (NAADP), a Ca(2+)-releasing agonist, in rat tissues. Biochem Biophys Res Commun. 1995 Apr 6; 209(1):167-74.
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  74. Beers KW, Chini EN, Lee HC, Dousa TP. Metabolism of cyclic ADP-ribose in opossum kidney renal epithelial cells. Am J Physiol. 1995 Mar; 268(3 Pt 1):C741-6.
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  75. Chini EN, Beers KW, Dousa TP. Nicotinate adenine dinucleotide phosphate (NAADP) triggers a specific calcium release system in sea urchin eggs. J Biol Chem. 1995 Feb 17; 270(7):3216-23.
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  76. Chini CC, Chini EN, Williams JM, Matousovic K, Dousa TP. Formation of reactive oxygen metabolites in glomeruli is suppressed by inhibition of cAMP phosphodiesterase isozyme type IV. Kidney Int. 1994 Jul; 46(1):28-36.
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  77. Chini EN, de Toledo FG, Albuquerque MC, de Meis L. The Ca(2+)-transporting ATPases of rabbit and trout exhibit different pH- and temperature-dependences. Biochem J. 1993 Jul 15; 293 ( Pt 2):469-73.
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  78. Chini EN, de Faria FO, Cardoso CM, de Meis L. The enhancement of Ca2+ efflux from sarcoplasmic reticulum vesicles by urea. Arch Biochem Biophys. 1992 Nov 15; 299(1):73-6.
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  79. Chini EN, Meyer-Fernandes JR, Sola-Penna M. Monosaccharides and disaccharides decrease the Km for phosphorylation of a membrane-bound enzyme ATPase. Z Naturforsch [C] 1991 Jul-Aug; 46(7-8):644-6.
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  80. Chini EN, Montero-Lomeli M, de Meis L. K(+)- and Mg2(+)-dependent hydrolysis of acetyl phosphate catalyzed by the (Ca2+ + Mg2+)-ATPase of sarcoplasmic reticulum. Biochim Biophys Acta. 1990 Nov 30; 1030(1):152-6.
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