Publications

  1. Huseby Kelcher AM, Atanga PA, Gamez JD, Cumba Garcia LM, Teclaw SJ, Pavelko KD, Macura SI, Johnson AJ. Brain atrophy in picornavirus-infected FVB mice is dependent on the H-2Db class I molecule. FASEB J. 2017 Jun; 31 (6):2267-2275 Epub 2017 Feb 10
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  2. Pavelko KD, Bell MP, Harrington SM, Dong H. B7-H1 Influences the Accumulation of Virus-Specific Tissue Resident Memory T Cells in the Central Nervous System. Front Immunol. 2017; 8:1532 Epub 2017 Nov 09
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  3. Willenbring RC, Jin F, Hinton DJ, Hansen M, Choi DS, Pavelko KD, Johnson AJ. Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption. J Neuroinflammation. 2016 Aug 31; 13 (1):222
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  4. Bell MP, Pavelko KD. Enhancing the Tumor Selectivity of a Picornavirus Virotherapy Promotes Tumor Regression and the Accumulation of Infiltrating CD8+ T Cells. Mol Cancer Ther. 2016 Mar; 15: (3)523-30.
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  5. Renner DN, Malo CS, Jin F, Parney IF, Pavelko KD, Johnson AJ. Improved Treatment Efficacy of Antiangiogenic Therapy when Combined with Picornavirus Vaccination in the GL261 Glioma Model. Neurotherapeutics. 2016 Jan; 13: (1)226-36.
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  6. Malo CS, Renner DN, Huseby Kelcher AM, Jin F, Hansen MJ, Pavelko KD, Johnson AJ. The Effect of Vector Silencing during Picornavirus Vaccination against Experimental Melanoma and Glioma. PLoS One. 2016; 11 (8):e0162064 Epub 2016 Aug 25
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  7. Renner DN, Jin F, Litterman AJ, Balgeman AJ, Hanson LM, Gamez JD, Chae M, Carlson BL, Sarkaria JN, Parney IF, Ohlfest JR, Pirko I, Pavelko KD, Johnson AJ. Effective Treatment of Established GL261 Murine Gliomas through Picornavirus Vaccination-Enhanced Tumor Antigen-Specific CD8+ T Cell Responses. PLoS One. 2015; 10: (5)e0125565.
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  8. Reed BK, Chopp LB, Malo CS, Renner DN, Van Keulen VS, Girtman MA, Nevala WN, Pavelko KD, Gil D, Schrum AG, Johnson AJ, Pease LR. A Versatile Simple Capture Assay for Assessing the Structural Integrity of MHC Multimer Reagents. PLoS One. 2015; 10: (9)e0137984.
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  9. Bell MP, Renner DN, Johnson AJ, Pavelko KD. A CD8 T-cell epitope variant enhances immune targeting to a recombinant picornavirus vaccine antigen. Viral Immunol. 2014 Sep; 27: (7)361-6.
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  10. Bell MP, Renner DN, Johnson AJ, Pavelko KD. An elite controller of picornavirus infection targets an epitope that is resistant to immune escape. PLoS One. 2014; 9: (4)e94332.
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  11. Pavelko KD, Bell MP, Karyampudi L, Hansen MJ, Allen KS, Knutson KL, Pease LR. The epitope integration site for vaccine antigens determines virus control while maintaining efficacy in an engineered cancer vaccine. Mol Ther. 2013 May; 21: (5)1087-95.
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  12. Pavelko KD, Mendez-Fernandez Y, Bell MP, Hansen MJ, Johnson AJ, David CS, Rodriguez M, Pease LR. Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity. PLoS Pathog. 2012 Feb; 8: (2)e1002541.
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  13. Pirko I, Chen Y, Lohrey AK, McDole J, Gamez JD, Allen KS, Pavelko KD, Lindquist DM, Dunn RS, Macura SI, Johnson AJ. Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation. PLoS One. 2012; 7: (2)e31459.
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  14. Suidan GL, Dickerson JW, Johnson HL, Chan TW, Pavelko KD, Pirko I, Seroogy KB, Johnson AJ. Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability. J Neuroinflammation. 2012; 9:218. Epub 2012 Sep 18.
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  15. Pavelko KD, Girtman MA, Mitsunaga Y, Mendez-Fernandez YV, Bell MP, Hansen MJ, Allen KS, Rodriguez M, Pease LR. Theiler's murine encephalomyelitis virus as a vaccine candidate for immunotherapy. PLoS One. 2011; 6: (5)e20217.
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  16. Wongthida P, Diaz RM, Galivo F, Kottke T, Thompson J, Pulido J, Pavelko K, Pease L, Melcher A, Vile R. Type III IFN interleukin-28 mediates the antitumor efficacy of oncolytic virus VSV in immune-competent mouse models of cancer. Cancer Res. 2010 Jun 1; 70: (11)4539-49.
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  17. Pavelko KD, Hansen MJ, Pease LR, Heckman KL. Retraction: An effective vaccine strategy protective against antigenically distinct tumor variants (Cancer Research (2008) 1). Cancer Res. 2010; 70(22):9528.
  18. Pavelko KD, Hansen MJ, Pease LR. Retraction: CTL activation using the natural low-affinity epitope 222-229 from tyrosinase-related protein 1 leads to tumor rejection (Cancer Research (2009) 1). Cancer Res. 2010; 70(22):9529.
  19. Pavelko KD, Hansen MJ, Pease LR. CTL activation using the natural low-affinity epitope 222-229 from tyrosinase-related protein 1 leads to tumor rejection. Cancer Res. 2009 Apr 1; 69 (7):3114-20 Epub 2009 Mar 10
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  20. Rodriguez M, Zoecklein L, Kerkvliet JG, Pavelko KD, Papke L, Howe CL, Pease LR, David C. Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination. J Virol. 2008 Apr; 82: (7)3369-80.
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  21. Pavelko KD, Heckman KL, Hansen MJ, Pease LR. An effective vaccine strategy protective against antigenically distinct tumor variants. Cancer Res. 2008 Apr 1; 68 (7):2471-8
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  22. Heckman KL, Schenk EL, Radhakrishnan S, Pavelko KD, Hansen MJ, Pease LR. Fast-tracked CTL: rapid induction of potent anti-tumor killer T cells in situ. Eur J Immunol. 2007 Jul; 37 (7):1827-35
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  23. Pavelko KD, Pease LR, David CS, Rodriguez M. Genetic deletion of a single immunodominant T-cell response confers susceptibility to virus-induced demyelination. Brain Pathol. 2007 Apr; 17: (2)184-96.
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  24. Rodriguez M, Zoecklein L, Gamez JD, Pavelko KD, Papke LM, Nakane S, Howe C, Radhakrishnan S, Hansen MJ, David CS, Warrington AE, Pease LR. STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis. FASEB J. 2006 Feb; 20(2):343-5. Epub 2005 Dec 13
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  25. Rodriguez M, Zoecklein LJ, Howe CL, Pavelko KD, Gamez JD, Nakane S, Papke LM. Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection. J Virol. 2003 Nov; 77: (22)12252-65.
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  26. Nakane S, Zoecklein LJ, Gamez JD, Papke LM, Pavelko KD, Bureau JF, Brahic M, Pease LR, Rodriguez M. A 40-cM region on chromosome 14 plays a critical role in the development of virus persistence, demyelination, brain pathology and neurologic deficits in a murine viral model of multiple sclerosis. Brain Pathol. 2003 Oct; 13(4):519-33.
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  27. Zoecklein LJ, Pavelko KD, Gamez J, Papke L, McGavern DB, Ure DR, Njenga MK, Johnson AJ, Nakane S, Rodriguez M. Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus. Brain Pathol. 2003 Jul; 13: (3)291-308.
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  28. Pavelko KD, Howe CL, Drescher KM, Gamez JD, Johnson AJ, Wei T, Ransohoff RM, Rodriguez M. Interleukin-6 protects anterior horn neurons from lethal virus-induced injury. J Neurosci. 2003 Jan 15; 23(2):481-92.
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  29. Lin XQ, Njenga MK, Johnson AJ, Pavelko KD, David CS, Pease LR, Rodriguez M. Transgenic expression of Theiler's murine encephalomyelitis virus genes in H-2(b) mice inhibits resistance to virus-induced demyelination. J Virol. 2002 Aug; 76(15):7799-811.
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  30. Ransohoff RM, Wei T, Pavelko KD, Lee JC, Murray PD, Rodriguez M. Chemokine expression in the central nervous system of mice with a viral disease resembling multiple sclerosis: Roles of CD4(+) and CD8(+) T cells and viral persistence. J Virol. 2002 Mar; 76(5):2217-24.
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  31. Johnson AJ, Upshaw J, Pavelko KD, Rodriguez M, Pease LR. Preservation of motor function by inhibition of CD8+virus peptide-specific T cells in Theiler's virus infection. FASEB J. 2001 Oct; 15(12):Nil_255-Nil_276.
  32. Rodriguez M, Roos RP, McGavern D, Zoecklein L, Pavelko K, Sang H, Lin X. The CD4-mediated immune response is critical in determining the outcome of infection using Theiler's viruses with VP1 capsid protein point mutations. Virology. 2000 Sep 15; 275 (1):9-19
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  33. Pavelko KD, Drescher KM, McGavern DB, David CS, Rodriguez M. HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis. Mol Cell Neurosci. 2000 Jun; 15: (6)495-509.
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  34. Drescher KM, Zoecklein LJ, Pavelko KD, Rivera-Quinones C, Hollenbaugh D, Rodriguez M. CD40L is critical for protection from demyelinating disease and development of spontaneous remyelination in a mouse model of multiple sclerosis. Brain Pathol. 2000 Jan; 10: (1)1-15.
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  35. Murray PD, Pavelko KD, Leibowitz J, Lin X, Rodriguez M. CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis. J Virol. 1998 Sep; 72: (9)7320-9.
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  36. Pavelko KD, van Engelen BG, Rodriguez M. Acceleration in the rate of CNS remyelination in lysolecithin-induced demyelination. J Neurosci. 1998 Apr 1; 18(7):2498-505.
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  37. Lucchinetti CF, Kimmel DW, Pavelko K, Rodriguez M. 5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus. Exp Neurol. 1997 Sep; 147(1):123-9.
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  38. van Engelen BG, Pavelko KD, Rodriguez M. Enhancement of central nervous system remyelination in immune and non-immune experimental models of demyelination. Mult Scler. 1997 Apr; 3: (2)76-9.
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  39. Rodriguez M, Pavelko KD, Njenga MK, Logan WC, Wettstein PJ. Balance between persistent virus infection and immune cells determines demyelination. J Immunol. 1996 Dec 15; 157(12):5699-5709.
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  40. Njenga MK, Pavelko KD, Baisch J, Lin X, David C, Leibowitz J, Rodriguez M. Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice. J Virol. 1996 Mar; 70: (3)1729-37.
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  41. Rodriguez M, Pavelko K, Coffman RL. Gamma interferon is critical for resistance to Theiler's virus-induced demyelination. J Virol. 1995 Nov; 69: (11)7286-90.
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  42. van Engelen BG, Miller DJ, Pavelko KD, Hommes OR, Rodriguez M. Promotion of remyelination by polyclonal immunoglobulin in Theiler's virus-induced demyelination and in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1994 Nov; 57 Suppl:65-8
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  43. Rodriguez M, Pavelko KD, McKinney CW, Leibowitz JL. Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis. J Immunol. 1994 Oct 15; 153(8):3811-21.
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