Publications

  1. Sainski AM, Dai H, Natesampillai S, Pang YP, Bren GD, Cummins NW, Correia C, Meng XW, Tarara JE, Ramirez-Alvarado M, Katzmann DJ, Ochsenbauer C, Kappes JC, Kaufmann SH, Badley AD. Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation. J Cell Biol. 2014 Sep 29; 206(7):867-76. Epub 2014 Sep 22.
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  2. Pang YP. Low-mass molecular dynamics simulation: A simple and generic technique to enhance configurational sampling. Biochem Biophys Res Commun. 2014 Sep 26; 452(3):588-92. Epub 2014 Aug 30.
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  3. Dai H, Pang YP, Ramirez-Alvarado M, Kaufmann SH. Evaluation of the BH3-only protein Puma as a direct Bak activator. J Biol Chem. 2014 Jan 3; 289(1):89-99. Epub 2013 Nov 21
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  4. Pang YP. Insect acetylcholinesterase as a target for effective and environmentally safe insecticides. Advances in Insect Physiology. 2014; 46:435-94.
  5. Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF. Substantial neuroprotection against K(+) deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway. CNS Neurosci Ther. 2013 Oct; 19(10):764-72. Epub 2013 Jul 04.
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  6. Hu S, Cui W, Mak S, Tang J, Choi C, Pang Y, Han Y. Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3beta pathways. Neurochem Int. 2013 Mar; 62(4):468-77. Epub 2013 Jan 26.
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  7. Kim MS, Machida Y, Vashisht AA, Wohlschlegel JA, Pang YP, Machida YJ. Regulation of error-prone translesion synthesis by Spartan/C1orf124. Nucleic Acids Res. 2013 Feb 1; 41(3):1661-8. Epub 2012 Dec 18.
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  8. Yu S, Park JG, Kahn JN, Tumer NE, Pang YP. Common pharmacophore of structurally distinct small-molecule inhibitors of intracellular retrograde trafficking of ribosome inactivating proteins. Sci Rep. 2013; 3:3397. Epub 2013 Dec 02.
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  9. Dou D, Park JG, Rana S, Madden BJ, Jiang H, Pang YP. Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases. Sci Rep. 2013; 3:1068. Epub 2013 Jan 15.
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  10. Yao L, Li W, She H, Dou J, Jia L, He Y, Yang Q, Zhu J, Capiro NL, Walker DI, Pennell KD, Pang Y, Liu Y, Han Y, Mao Z. Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects. J Biol Chem. 2012 Oct 5; 287(41):34246-55. Epub 2012 Aug 13.
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  11. Pang YP, Brimijoin S, Ragsdale DW, Zhu KY, Suranyi R. Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides. Curr Drug Targets. 2012 Apr; 13(4):471-82.
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  12. Pang YP, Dai HM, Smith A, Meng XW, Schneider PA, Kaufmann SH. Bak conformational changes induced by ligand binding: insight into bh3 domain binding and bak homo-oligomerization. Scientific Reports. 2012 Feb 10; 2.
  13. Lu Y, Pang YP, Park Y, Gao X, Yao J, Zhang X, Zhu KY. Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle. PLoS One. 2012; 7(2):e32288. Epub 2012 Feb 16.
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  14. Lu Y, Park Y, Gao X, Zhang X, Yao J, Pang YP, Jiang H, Zhu KY. Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum. Sci Rep. 2012; 2:288. Epub 2012 Feb 27.
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  15. Park JG, Kahn JN, Tumer NE, Pang YP. Chemical structure of Retro-2, a compound that protects cells against ribosome-inactivating proteins. Sci Rep. 2012; 2:631. Epub 2012 Sep 5.
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  16. Dai H, Smith A, Meng XW, Schneider PA, Pang YP, Kaufmann SH. Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization. J Cell Biol. 2011 Jul 11; 194(1):39-48. Epub 2011 Jul 04.
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  17. Pang YP, Park JG, Wang S, Vummenthala A, Mishra RK, McLaughlin JE, Di R, Kahn JN, Tumer NE, Janosi L, Davis J, Millard CB. Small-molecule inhibitor leads of ribosome-inactivating proteins developed using the doorstop approach. PLoS One. 2011; 6(3):e17883. Epub 2011 Mar 24.
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  18. Wille T, Ekstrom F, Lee JC, Pang YP, Thiermann H, Worek F. Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds. Biochem Pharmacol. 2010 Sep 15; 80(6):941-6. Epub 2010 May 26.
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  19. Polsinelli GA, Singh SK, Mishra RK, Suranyi R, Ragsdale DW, Pang YP, Brimijoin S. Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle. Chem Biol Interact. 2010 Sep 6; 187(1-3):142-7. Epub 2010 Jan 28.
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  20. Luo J, Li W, Zhao Y, Fu H, Ma DL, Tang J, Li C, Peoples RW, Li F, Wang Q, Huang P, Xia J, Pang Y, Han Y. Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin. J Biol Chem. 2010 Jun 25; 285(26):19947-58. Epub 2010 Apr 19.
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  21. Hornberg A, Artursson E, Warme R, Pang YP, Ekstrom F. Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad. Biochem Pharmacol. 2010 Feb 1; 79(3):507-15. Epub 2009 Sep 02.
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  22. Pang YP, Davis J, Wang S, Park JG, Nambiar MP, Schmidt JJ, Millard CB. Small molecules showing significant protection of mice against botulinum neurotoxin serotype A. PLoS One. 2010; 5(4):e10129. Epub 2010 Apr 13.
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  23. Fu H, Dou J, Li W, Cui W, Mak S, Hu Q, Luo J, Lam CS, Pang Y, Youdim MB, Han Y. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently. Eur J Pharmacol. 2009 Nov 25; 623(1-3):14-21. Epub 2009 Sep 16.
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  24. Yao K, Cho YY, Bode AM, Vummenthala A, Park JG, Liu K, Pang YP, Dong Z. A selective small-molecule inhibitor of c-Jun N-terminal kinase 1. FEBS Lett. 2009 Jul 7; 583(13):2208-12. Epub 2009 Jun 13.
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  25. Zhou L, Liu YW, Peoples RW, Yang M, Tian X, Ai YX, Pang YP, Li ZW, Han YF, Li CY. Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons. Neuropharmacology. 2009 Jul; 57(1):33-40. Epub 2009 Apr 22.
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  26. Killian BJ, Kravitz JY, Somani S, Dasgupta P, Pang YP, Gilson MK. Configurational entropy in protein-peptide binding: computational study of Tsg101 ubiquitin E2 variant domain with an HIV-derived PTAP nonapeptide. J Mol Biol. 2009 Jun 5; 389(2):315-35. Epub 2009 Apr 09.
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  27. Tomlinson SM, Malmstrom RD, Russo A, Mueller N, Pang YP, Watowich SJ. Structure-based discovery of dengue virus protease inhibitors. Antiviral Res. 2009 Jun; 82(3):110-4. Epub 2009 Feb 21.
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  28. Pang YP, Ekstrom F, Polsinelli GA, Gao Y, Rana S, Hua DH, Andersson B, Andersson PO, Peng L, Singh SK, Mishra RK, Zhu KY, Fallon AM, Ragsdale DW, Brimijoin S. Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases. PLoS One. 2009; 4(8):e6851. Epub 2009 Aug 28.
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  29. Pang YP, Singh SK, Gao Y, Lassiter TL, Mishra RK, Zhu KY, Brimijoin S. Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides. PLoS One. 2009; 4(2):e4349. Epub 2009 Feb 04.
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  30. Pang YP, Vummenthala A, Mishra RK, Park JG, Wang S, Davis J, Millard CB, Schmidt JJ. Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design. PLoS One. 2009; 4(11):e7730. Epub 2009 Nov 10.
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  31. Ekstrom F, Hornberg A, Artursson E, Hammarstrom LG, Schneider G, Pang YP. Structure of HI-6-sarin-acetylcholinesterase determined by x-ray crystallography and molecular dynamics simulation: Reactivator mechanism and design. PLoS ONE. 2009; 4(6).
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  32. Zhao Y, Li W, Chow PC, Lau DT, Lee NT, Pang Y, Zhang X, Wang X, Han Y. Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia. Neurosci Lett. 2008 Jul 11; 439(2):160-4. Epub 2008 May 08.
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  33. Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Gu ZM, Chan K, Wang YT, Zuo Z, Han YF. Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine. Int J Pharm. 2008 Jun 5; 357(1-2):85-94. Epub 2008 Feb 02.
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  34. Liu YW, Luo JL, Ren H, Peoples RW, Ai YX, Liu LJ, Pang YP, Li ZW, Han YF, Li CY. Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies. Neuropharmacology. 2008 Jun; 54(7):1086-94. Epub 2008 Mar 02.
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  35. Liu YW, Li CY, Luo JL, Li WM, Fu HJ, Lao YZ, Liu LJ, Pang YP, Chang DC, Li ZW, Peoples RW, Ai YX, Han YF. Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors. Biochem Biophys Res Commun. 2008 May 16; 369(4):1007-11. Epub 2008 Mar 06.
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  36. Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Lin G, Wang YT, Zuo Z, Han YF. Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2008 Apr; 22(4):414-20.
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  37. Fu H, Li W, Luo J, Lee NT, Li M, Tsim KW, Pang Y, Youdim MB, Han Y. Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity. Biochem Biophys Res Commun. 2008 Feb 15; 366(3):631-6. Epub 2007 Nov 26.
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  38. Choi J, Park JG, Pang YP. Convenient Synthesis of a Library of Discrete Hydroxamic Acids Using the Hydroxythiophenol (Marshall) Resin. Tetrahedron Lett. 2008 Feb 11; 49(7):1103-1106.
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  39. Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K, Wang YT, Han YF. The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine. J Pharm Biomed Anal. 2008 Jan 7; 46(1):75-81. Epub 2007 Sep 04.
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  40. Pang YP, Mullins TJ, Swartz BA, McAllister JS, Smith BE, Archer CJ, Musselman RG, Peters AE, Wallenfelt BP, Pinnow KW. EUDOC on the IBM Blue Gene/L system: Accelerating the transfer of drug discoveries from laboratory to patient. IBM Journal of Research & Development. 2008 Jan-Mar; 52(1-2):69-81.
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  41. Luo J, Li W, Liu Y, Zhang W, Fu H, Lee NT, Yu H, Pang Y, Huang P, Xia J, Li ZW, Li C, Han Y. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. Biochem Biophys Res Commun. 2007 Sep 21; 361(2):505-9. Epub 2007 Jul 20.
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  42. Yu H, Ho JMK, Kan KKW, Cheng BWH, Li WM, Zhang L, Lin G, Pang YP, Gu ZM, Chan K, Wang YT, Han YF. Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood. J Pharm Biomed Anal. 2007 Sep 3; 44(5):1133-8.
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  43. Ekstrom FJ, Astot C, Pang YP. Novel nerve-agent antidote design based on crystallographic and mass spectrometric analyses of tabun-conjugated acetylcholinesterase in complex with antidotes. Clin Pharmacol Ther. 2007 Sep; 82(3):282-93. Epub 2007 Apr 18.
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  44. Li WM, Kan KK, Carlier PR, Pang YP, Han YF. East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A. Curr Alzheimer Res. 2007 Sep; 4(4):386-96.
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  45. Fu H, Li W, Liu Y, Lao Y, Liu W, Chen C, Yu H, Lee NT, Chang DC, Li P, Pang Y, Tsim KW, Li M, Han Y. Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons. J Proteome Res. 2007 Jul; 6(7):2435-46. Epub 2007 May 27.
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  46. Li W, Xue J, Niu C, Fu H, Lam CS, Luo J, Chan HH, Xue H, Kan KK, Lee NT, Li C, Pang Y, Li M, Tsim KW, Jiang H, Chen K, Li X, Han Y. Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase. Mol Pharmacol. 2007 May; 71(5):1258-67.
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  47. Babady NE, Pang YP, Elpeleg O, Isaya G. Cryptic proteolytic activity of dihydrolipoamide dehydrogenase. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6158-63. Epub 2007 Apr 02.
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  48. Le SB, Hailer MK, Buhrow S, Wang Q, Flatten K, Pediaditakis P, Bible KC, Lewis LD, Sausville EA, Pang YP, Ames MM, Lemasters JJ, Holmuhamedov EL, Kaufmann SH. Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity. J Biol Chem. 2007 Mar 23; 282(12):8860-72. Epub 2007 Jan 09.
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  49. Nie H, Yu WJ, Li XY, Yuan CH, Pang YP, Li CY, Han YF, Li ZW. Inhibition by bis(7)-tacrine of native delayed rectifier and KV1.2 encoded potassium channels. Neurosci Lett. 2007 Jan 29; 412(2):108-13.
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  50. Pang YP. Species marker for developing novel and safe pesticides. Bioorg Med Chem Lett. 2007 Jan 1; 17(1):197-9. Epub 2006 Oct 12.
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  51. Pang YP. In silico drug discovery: Solving the "target-rich and lead-poor" imbalance using the genome-to-drug-lead paradigm. Clin Pharmacol Ther. 2007 Jan; 81(1):30-4.
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  52. Li C-Y, Carlier PR, Ren H, Kan KKW, Hui K-M, Wang H, Li W-M, Li Z-W, Xiong K, Clement EC, Xue H, Lui X-G, Li M-T, Pang Y-P, Han Y-F. Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers. Neuropharmacology. 2007; 52:436-43.
  53. Wang Q, Pang YP. Accurate reproduction of 161 small-molecule complex crystal structures using the EUDOC program: expanding the use of EUDOC to supramolecular chemistry. PLoS One. 2007; 2(6):e531. Epub 2007 Jun 13.
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  54. Wang Q, Pang YP. Preference of small molecules for local minimum conformations when binding to proteins. PLoS One. 2007; 2(9):e820. Epub 2007 Sep 05.
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  55. Wang Q, Pang YP. Normal-mode-analysis-monitored energy minimization procedure for generating small-molecule bound conformations. PLoS One. 2007; 2(10):e1025. Epub 2007 Oct 10.
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  56. Tang J, Park JG, Millard CB, Schmidt JJ, Pang YP. Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A. PLoS One. 2007; 2(8):e761. Epub 2007 Aug 22.
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  57. Lipinski CA, Tran NL, Dooley A, Pang YP, Rohl C, Kloss J, Yang Z, McDonough W, Craig D, Berens ME, Loftus JC. Critical role of the FERM domain in Pyk2 stimulated glioma cell migration. Biochem Biophys Res Commun. 2006 Oct 27; 349(3):939-47. Epub 2006 Aug 31.
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  58. Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL. Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge. J Med Chem. 2006 Sep 7; 49(18):5491-500.
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  59. Fu H, Li W, Lao Y, Luo J, Lee NT, Kan KK, Tsang HW, Tsim KW, Pang Y, Li Z, Chang DC, Li M, Han Y. Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels. J Neurochem. 2006 Sep; 98(5):1400-10. Epub 2006 Jun 12.
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  60. Ekstrom F, Pang YP, Boman M, Artursson E, Akfur C, Borjegren S. Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates. Biochem Pharmacol. 2006 Aug 28; 72(5):597-607. Epub 2006 Jul 31.
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  61. Merino I, Thompson JD, Millard CB, Schmidt JJ, Pang YP. Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A. Bioorg Med Chem. 2006 May 15; 14(10):3583-91. Epub 2006 Feb 02.
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  62. Li W, Lee NT, Fu H, Kan KK, Pang Y, Li M, Tsim KW, Li X, Han Y. Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. Neuroreport. 2006 Apr 3; 17(5):471-4.
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  63. Dooley AJ, Shindo N, Taggart B, Park JG, Pang YP. From genome to drug lead: identification of a small-molecule inhibitor of the SARS virus. Bioorg Med Chem Lett. 2006 Feb 15; 16(4):830-3. Epub 2005 Dec 01.
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  64. Park JG, Sill PC, Makiyi EF, Garcia-Sosa AT, Millard CB, Schmidt JJ, Pang YP. Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A. Bioorg Med Chem. 2006 Jan 15; 14(2):395-408. Epub 2005 Oct 03.
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  65. Zaidi JH, Naeem F, Ambreen N, Khan KM, Pang YP, Cusack B, Richelson E, Anwar A, Voelter W. Pyrrole-based partial peptidic mimic of neurotensin (8-13): Design and synthesis. Letters in Organic Chemistry. 2006 Jan; 3(1):21-4.
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  66. Pang YP. Novel acetylcholinesterase target site for malaria mosquito control. PLoS One. 2006; 1:e58. Epub 2006 Dec 20.
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  67. Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL. Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase. J Am Chem Soc. 2005 Aug 10; 127(31):11029-36.
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  68. Li WM, Pi RB, Chan HHN, Fu HJ, Lee NTK, Tsang HW, Pu YM, Chang DC, Li CY, Luo JL, Xiong KM, Li ZW, Xue H, Carlier PR, Pang YP, Tsim KWK, Li MT, Han YF. Novel dimeric acetylcholinesterase inhibitor bis(7)-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors. J Biol Chem. 2005 May 6; 280(18):18179-88.
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  69. Patani GA, Pang YP, Chien YW. A Potent and Selective Tacrine Analog - Biomembrane Permeation and Physicochemical Characterization. Pharm Dev Technol. 2005; 10:525-538.
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  70. Pang YP. Three-dimensional model of a substrate-bound SARS chymotrypsin-like cysteine proteinase predicted by multiple molecular dynamics simulations: Catalytic efficiency regulated by substrate binding. Proteins Structure Function & Bioinformatics. 2004 Dec 1; 57(4):747-57.
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  71. Grossmann ME, Madden BJ, Gao F, Pang YP, Carpenter JE, McCormick D, Young CY. Proteomics shows Hsp70 does not bind peptide sequences indiscriminately in vivo. Exp Cell Res. 2004 Jul 1; 297(1):108-17.
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  72. Luo JL, Zhang J, Guan BC, Pang YP, Han YF, Li ZW. Inhibition by bis(7)-tacrine of 5-HT-activated current in rat TG neurons. Neuroreport. 2004 Jun 7; 15(8):1335-8.
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  73. Pang YP. Nonbonded bivalence approach to cell-permeable molecules that target DNA sequences. Bioorg Med Chem. 2004 Jun 1; 12(11):3063-8.
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  74. Park JG, Langenwalter KJ, Weinbaum CA, Casey PJ, Pang YP. Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: Synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors. Journal of Combinatorial Chemistry. 2004 May-Jun; 6(3):407-13.
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  75. Bienengraeber M, Olson TM, Selivanov VA, Kathmann EC, O'Cochlain F, Gao F, Karger AB, Ballew JD, Hodgson DM, Zingman LV, Pang YP, Alekseev AE, Terzic A. ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nat Genet. 2004 Apr; 36(4):382-7. Epub 2004 Mar 21.
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  76. Hammond PI, Kern C, Hong F, Kollmeyer TM, Pang YP, Brimijoin S. Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design. J Pharmacol Exp Ther. 2003 Oct 1; 307(1):190-6.
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  77. Pang YP, Kumar GA, Zhang JS, Urrutia R. Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A. FEBS Lett. 2003 Jul 31; 548(1-3):108-12.
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  78. Pang YP, Kollmeyer TM, Hong F, Lee JC, Hammond PI, Haugabouk SP, Brimijoin S. Rational design of alkylene-linked bis-pyridiniumalidoximes as improved acetylcholinesterase reactivators. Chem Biol. 2003 Jun; 10(6):491-502.
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  79. Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. Acetylcholinesterase complexed with bivalent ligands related to huperzine A: Experimental evidence for species-dependent protein-ligand complementarity. J Am Chem Soc. 2003 Jan 15; 125(2):363-73.
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  80. Zhang JC, Donate F, Qi XP, Ziats NP, Juarez JC, Mazar AP, Pang YP, McCrae KR. The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosin. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12224-9.
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  81. Sun H, Pang YP, Lockridge O, Brimijoin S. Re-engineering butyrylcholinesterase as a cocaine hydrolase. Mol Pharmacol. 2002 Aug; 62(2):220-4.
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  82. Sun H, Shen ML, Pang YP, Lockridge O, Brimijoin S. Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase. J Pharmacol Exp Ther. 2002 Aug; 302(2):710-6.
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  83. Pan SY, Han YF, Carlier PR, Pang YP, Mak DHF, Lam BYH, Ko KM. Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice. Planta Med. 2002 Mar; 68(3):217-20.
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  84. Pang YP, Perola E, Xu K, Prendergast FG. EUDOC: a computer program for identification of drug interaction sites in macromolecules and drug leads from chemical databases. J Comput Chem. 2001 Nov 30; 22(15):1750-1771.
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  85. Pang YP. Successful molecular dynamics simulation of two zinc complexes bridged by a hydroxide in phosphotriesterase using the cationic dummy atom method. Proteins. 2001 Nov 15; 45(3):183-9.
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  86. Pang YP, Zheng XE, Weinshilboum RM. Theoretical 3D model of histamine N-methyltransferase: insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability. Biochem Biophys Res Commun. 2001 Sep 14; 287(1):204-8.
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  87. Pang YP, Xu K, Kollmeyer TM, Perola E, McGrath WJ, Green DT, Mangel WF. Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases. FEBS Lett. 2001 Aug 3; 502(3):93-7.
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  88. Lewis S, Karrer J, Saleh S, Chan X, Tan Z, Hua D, McGill J, Pang YP, Fenwick B, Brightman A, Takemoto D. Synthesis and evaluation of novel aldose reductase inhibitors: Effects on lens protein kinase Cgamma. Mol Vis. 2001 Jul 18(7):164-71.
  89. El Yazal J, Pang YP. Comparison of DFT, Moller-Plesset, and coupled cluster calculations of the proton dissociation energies of imidazole and N-methylacetamide in the presence of zinc(II). Theochem. 2001 Jul 9(545):271-274.
  90. Ros E, Aleu J, Gomez de Aranda I, Canti C, Pang YP, Marsal J, Solsona C. Effects of bis(7)-tacrine on spontaneous synaptic activity and on the nicotinic ACh receptor of Torpedo electric organ. J Neurophysiol. 2001 Jul; 86(1):183-9.
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  91. Mangel WF, McGrath WJ, Brown MT, Baniecki ML, Barnard DL, Pang YP. A new form of antiviral combination therapy predicted to prevent resistance from arising, and a model system to test it. Curr Med Chem. 2001 Jul; 8(8):933-9.
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  92. Sun H, El Yazal J, Lockridge O, Schopfer LM, Brimijoin S, Pang YP. Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication. J Biol Chem. 2001 Mar 23; 276(12):9330-6. Epub 2000 Dec 04.
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  93. Thompson MA, Weinshilboum RM, El Yazal J, Wood TC, Pang YC. Rabbit indolethylamine N-methyltransferase three-dimensional structure prediction: a model approach to bridge sequence to function in pharmacogenomic studies. Journal of Molecular Modeling. 2001; 7(9):324-333.
  94. El Yazal J, Prendergast FG, Shaw DE, Pang YP. Protonation states of the chromophore of denatured green fluorescent proteins predicted by ab initio calculations. J Am Chem Soc. 2000 Nov 22; 122(46):11411-5.
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  95. Pang YP, Xu K, Yazal JE, Prendergas FG. Successful molecular dynamics simulation of the zinc-bound farnesyltransferase using the cationic dummy atom approach. Protein Sci. 2000 Oct; 9(10):1857-65.
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  96. Cusack B, Jansen K, McCormick DJ, Chou T, Pang Y, Richelson E. A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist. Biochem Pharmacol. 2000 Sep 15; 60(6):793-801.
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