Publications

  1. Wang D, Fu L, Ning W, Guo L, Sun X, Dey SK, Chaturvedi R, Wilson KT, DuBois RN. Peroxisome proliferator-activated receptor delta promotes colonic inflammation and tumor growth. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):7084-9. Epub 2014 Apr 24.
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  2. Charo C, Holla V, Arumugam T, Hwang R, Yang P, Dubois RN, Menter DG, Logsdon CD, Ramachandran V. Prostaglandin E2 regulates pancreatic stellate cell activity via the EP4 receptor. Pancreas. 2013 Apr; 42(3):467-74.
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  3. Wang D, DuBois RN. The role of anti-inflammatory drugs in colorectal cancer. Annu Rev Med. 2013; 64:131-44. Epub 2012 Sep 27.
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  4. Cantley LC, Dalton WS, DuBois RN, Finn OJ, Futreal PA, Golub TR, Hait WN, Lozano G, Maris JM, Nelson WG, Sawyers CL, Schreiber SL, Spitz MR, Steeg PS. AACR Cancer Progress Report 2012. Clin Cancer Res. 2012 Nov 1; 18(21 Suppl):S1-100. Epub 2012 Sep 11.
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  5. Lin M, Gu J, Eng C, Ellis LM, Hildebrandt MA, Lin J, Huang M, Calin GA, Wang D, Dubois RN, Hawk ET, Wu X. Genetic polymorphisms in MicroRNA-related genes as predictors of clinical outcomes in colorectal adenocarcinoma patients. Clin Cancer Res. 2012 Jul 15; 18(14):3982-91. Epub 2012 Jun 01.
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  6. Spinks T, Albright HW, Feeley TW, Walters R, Burke TW, Aloia T, Bruera E, Buzdar A, Foxhall L, Hui D, Summers B, Rodriguez A, Dubois R, Shine KI. Ensuring quality cancer care: a follow-up review of the Institute of Medicine's 10 recommendations for improving the quality of cancer care in America. Cancer. 2012 May 15; 118(10):2571-82. Epub 2011 Nov 01.
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  7. Wang D, Ning W, Xie D, Guo L, DuBois RN. Peroxisome proliferator-activated receptor delta confers resistance to peroxisome proliferator-activated receptor gamma-induced apoptosis in colorectal cancer cells. Oncogene. 2012 Feb 23; 31(8):1013-23. Epub 2011 Jul 18.
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  8. Anderson KC, DuBois RN. Overview of the AACR Clinical and Translational Cancer Research Think Tank meeting. Clin Cancer Res. 2012 Feb 1; 18(3):607-11.
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  9. Xia D, Wang D, Kim SH, Katoh H, DuBois RN. Prostaglandin E2 promotes intestinal tumor growth via DNA methylation. Nat Med. 2012 Feb; 18(2):224-6. Epub 2012 Jan 22.
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  10. Ross W, Lynch P, Raju G, Rodriguez A, Burke T, Hafemeister L, Hawk E, Wu X, Dubois RN, Mishra L. Biomarkers, bundled payments, and colorectal cancer care. Genes Cancer. 2012 Jan; 3(1):16-22.
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  11. Menter DG, Dubois RN. Prostaglandins in cancer cell adhesion, migration, and invasion. Int J Cell Biol. 2012; 2012:723419. Epub 2012 Feb 29.
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  12. Kim SH, Park YY, Kim SW, Lee JS, Wang D, DuBois RN. ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression. Cancer Res. 2011 Nov 15; 71(22):7010-20. Epub 2011 Sep 21.
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  13. Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, Huo L, Cheng X, Chen YJ, Li CW, Jeng LB, Hsu JL, Li LY, Tan A, Curley SA, Ellis LM, Dubois RN, Hung MC. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. J Clin Invest. 2011 Nov; 121(11):4526-36. Epub 2011 Oct 10.
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  14. Holla VR, Wu H, Shi Q, Menter DG, DuBois RN. Nuclear orphan receptor NR4A2 modulates fatty acid oxidation pathways in colorectal cancer. J Biol Chem. 2011 Aug 26; 286(34):30003-9. Epub 2011 Jul 10.
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  15. Wang D, DuBois RN. Therapeutic potential of peroxisome proliferator-activated receptors in chronic inflammation and colorectal cancer. Gastroenterol Clin North Am. 2010 Sep; 39(3):697-707.
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  16. Kim SH, Xia D, Kim SW, Holla V, Menter DG, Dubois RN. Human enhancer of filamentation 1 Is a mediator of hypoxia-inducible factor-1alpha-mediated migration in colorectal carcinoma cells. Cancer Res. 2010 May 15; 70(10):4054-63. Epub 2010 May 04.
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  17. Speirs CK, Jernigan KK, Kim SH, Cha YI, Lin F, Sepich DS, DuBois RN, Lee E, Solnica-Krezel L. Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. Development. 2010 Apr; 137(8):1327-37.
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  18. Menter DG, Schilsky RL, DuBois RN. Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward. Clin Cancer Res. 2010 Mar 1; 16(5):1384-90. Epub 2010 Feb 23.
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  19. Wang D, Dubois RN. Eicosanoids and cancer. Nat Rev Cancer. 2010 Mar; 10(3):181-93. Epub 2010 Feb 19.
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  20. Wang D, Dubois RN. The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene. 2010 Feb 11; 29(6):781-8. Epub 2009 Nov 30.
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  21. Xia D, Holla VR, Wang D, Menter DG, DuBois RN. HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells. Cancer Res. 2010 Jan 15; 70(2):824-31. Epub 2010 Jan 12.
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  22. Peddareddigari VG, Wang D, Dubois RN. The tumor microenvironment in colorectal carcinogenesis. Cancer Microenviron. 2010; 3(1):149-66. Epub 2010 Mar 05.
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  23. Wang D, Dubois RN, Richmond A. The role of chemokines in intestinal inflammation and cancer. Curr Opin Pharmacol. 2009 Dec; 9(6):688-96. Epub 2009 Sep 04.
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  24. DuBois RN. Tailoring treatment in translational cancer research: An Interview with Raymond N. DuBois, MD, PhD. Interviewed by Elaine Musgrave. Clin Transl Sci. 2009 Jun; 2(3):178-9.
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  25. Pedchenko TV, Gonzalez AL, Wang D, DuBois RN, Massion PP. Peroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer. Am J Respir Cell Mol Biol. 2008 Dec; 39(6):689-96. Epub 2008 Jun 19.
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  26. Backlund MG, Mann JR, Holla VR, Shi Q, Daikoku T, Dey SK, DuBois RN. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res. 2008 Nov 15; 68(22):9331-7.
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  27. Wang D, DuBois RN. Pro-inflammatory prostaglandins and progression of colorectal cancer. Cancer Lett. 2008 Aug 28; 267(2):197-203. Epub 2008 Apr 11.
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  28. Wang D, Wang H, Ning W, Backlund MG, Dey SK, DuBois RN. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res. 2008 Aug 1; 68(15):6468-76.
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  29. Holla VR, Backlund MG, Yang P, Newman RA, DuBois RN. Regulation of prostaglandin transporters in colorectal neoplasia. Cancer Prev Res (Phila). 2008 Jul; 1(2):93-9. Epub 2008 Mar 19.
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  30. Wang D, Dubois RN. Peroxisome proliferator-activated receptors and progression of colorectal cancer. PPAR Res. 2008; 2008:931074.
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  31. Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN, Dey SK. Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success. J Biol Chem. 2007 Dec 28; 282(52):37770-82. Epub 2007 Oct 26.
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  32. Lee SH, Rangiah K, Williams MV, Wehr AY, DuBois RN, Blair IA. Cyclooxygenase-2-mediated metabolism of arachidonic acid to 15-oxo-eicosatetraenoic acid by rat intestinal epithelial cells. Chem Res Toxicol. 2007 Nov; 20(11):1665-75. Epub 2007 Oct 02.
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  33. Buchanan FG, Holla V, Katkuri S, Matta P, DuBois RN. Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer. Cancer Res. 2007 Oct 1; 67(19):9380-8.
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  34. Horikawa Y, Otaka M, Komatsu K, Jin M, Odashima M, Wada I, Matsuhashi T, Ohba R, Oyake J, Hatakeyama N, Dubois RN, Watanabe S. MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism. Dig Dis Sci. 2007 Oct; 52(10):2757-65. Epub 2007 Mar 28.
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  35. Daikoku T, Tranguch S, Chakrabarty A, Wang D, Khabele D, Orsulic S, Morrow JD, Dubois RN, Dey SK. Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer. Cancer Res. 2007 Jun 1; 67(11):5285-92.
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  36. Wang D, DuBois RN. Inflammatory mediators and nuclear receptor signaling in colorectal cancer. Cell Cycle. 2007 Mar 15; 6(6):682-5. Epub 2007 Mar 21.
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  37. Cha YI, DuBois RN. NSAIDs and cancer prevention: targets downstream of COX-2. Annu Rev Med. 2007; 58:239-52.
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  38. Wang D, DuBois RN. Measurement of eicosanoids in cancer tissues. Methods Enzymol. 2007; 433:27-50.
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  39. Wang D, Wang H, Guo Y, Ning W, Katkuri S, Wahli W, Desvergne B, Dey SK, DuBois RN. Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):19069-74. Epub 2006 Dec 05.
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  40. Buchanan FG, DuBois RN. Emerging roles of beta-arrestins. Cell Cycle. 2006 Sep; 5(18):2060-3. Epub 2006 Sep 15.
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  41. Mann JR, Backlund MG, Buchanan FG, Daikoku T, Holla VR, Rosenberg DW, Dey SK, DuBois RN. Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression. Cancer Res. 2006 Jul 1; 66(13):6649-56.
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  42. Batts LE, Polk DB, Dubois RN, Kulessa H. Bmp signaling is required for intestinal growth and morphogenesis. Dev Dyn. 2006 Jun; 235(6):1563-70.
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  43. Wang D, Wang H, Brown J, Daikoku T, Ning W, Shi Q, Richmond A, Strieter R, Dey SK, DuBois RN. CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med. 2006 Apr 17; 203(4):941-51. Epub 2006 Mar 27.
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  44. Holla VR, Mann JR, Shi Q, DuBois RN. Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. J Biol Chem. 2006 Feb 3; 281(5):2676-82. Epub 2005 Nov 17.
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  45. Buchanan FG, Gorden DL, Matta P, Shi Q, Matrisian LM, DuBois RN. Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1492-7. Epub 2006 Jan 23.
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  46. Cha YI, Solnica-Krezel L, DuBois RN. Fishing for prostanoids: deciphering the developmental functions of cyclooxygenase-derived prostaglandins. Dev Biol. 2006 Jan 15; 289(2):263-72. Epub 2005 Nov 28.
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  47. Cha YI, Kim SH, Sepich D, Buchanan FG, Solnica-Krezel L, DuBois RN. Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Genes Dev. 2006 Jan 1; 20(1):77-86.
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  48. DuBois RN. The COX-2 story: is any drug completely "safe?". Gastroenterology. 2006 Jan; 130(1):6.
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  49. Wang D, Dubois RN. Prostaglandins and cancer. Gut. 2006 Jan; 55(1):115-22. Epub 2005 Aug 23.
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  50. Backlund MG, Mann JR, Wang D, Dubois RN. Ras up-regulation of cyclooxygenase-2. Methods Enzymol. 2006; 407:401-10.
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  51. Komatsu K, Buchanan FG, Otaka M, Jin M, Odashima M, Horikawa Y, Watanabe S, Dubois RN. Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells. Mol Cancer. 2006; 5:63. Epub 2006 Nov 17.
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  52. Musiek ES, Gao L, Milne GL, Han W, Everhart MB, Wang D, Backlund MG, DuBois RN, Zanoni G, Vidari G, Blackwell TS, Morrow JD. Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages. J Biol Chem. 2005 Oct 21; 280(42):35562-70. Epub 2005 Aug 12.
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  53. Peek RM Jr, Mohla S, DuBois RN. Inflammation in the genesis and perpetuation of cancer: summary and recommendations from a national cancer institute-sponsored meeting. Cancer Res. 2005 Oct 1; 65(19):8583-6.
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  54. Lee SH, Williams MV, Dubois RN, Blair IA. Cyclooxygenase-2-mediated DNA damage. J Biol Chem. 2005 Aug 5; 280(31):28337-46. Epub 2005 Jun 17.
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  55. Komatsu K, Buchanan FG, Katkuri S, Morrow JD, Inoue H, Otaka M, Watanabe S, DuBois RN. Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2. Gastroenterology. 2005 Aug; 129(2):577-90.
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  56. Cha YI, Kim SH, Solnica-Krezel L, Dubois RN. Cyclooxygenase-1 signaling is required for vascular tube formation during development. Dev Biol. 2005 Jun 1; 282(1):274-83.
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  57. Daikoku T, Wang D, Tranguch S, Morrow JD, Orsulic S, DuBois RN, Dey SK. Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res. 2005 May 1; 65(9):3735-44.
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  58. Wang D, Mann JR, DuBois RN. The role of prostaglandins and other eicosanoids in the gastrointestinal tract. Gastroenterology. 2005 May; 128(5):1445-61.
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  59. Brown JR, DuBois RN. COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol. 2005 Apr 20; 23(12):2840-55.
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  60. Mann JR, Backlund MG, DuBois RN. Mechanisms of disease: Inflammatory mediators and cancer prevention. Nat Clin Pract Oncol. 2005 Apr; 2(4):202-10.
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  61. Wang D, Buchanan FG, Wang H, Dey SK, DuBois RN. Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. Cancer Res. 2005 Mar 1; 65(5):1822-9.
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  62. Backlund MG, Mann JR, Holla VR, Buchanan FG, Tai HH, Musiek ES, Milne GL, Katkuri S, DuBois RN. 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. J Biol Chem. 2005 Feb 4; 280(5):3217-23. Epub 2004 Nov 12.
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  63. Buchanan FG, McReynolds M, Couvillon A, Kam Y, Holla VR, Dubois RN, Exton JH. Requirement of phospholipase D1 activity in H-RasV12-induced transformation. Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5):1638-42. Epub 2005 Jan 24.
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  64. Dannenberg AJ, Lippman SM, Mann JR, Subbaramaiah K, DuBois RN. Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention. J Clin Oncol. 2005 Jan 10; 23(2):254-66.
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  65. Holla VR, Wang D, Brown JR, Mann JR, Katkuri S, DuBois RN. Prostaglandin E2 regulates the complement inhibitor CD55/decay-accelerating factor in colorectal cancer. J Biol Chem. 2005 Jan 7; 280(1):476-83. Epub 2004 Nov 01.
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  66. Backlund MG, Mann JR, Dubois RN. Mechanisms for the prevention of gastrointestinal cancer: the role of prostaglandin E2. Oncology. 2005; 69 Suppl 1:28-32. Epub 2005 Sep 19.
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  67. Wang D, Mann JR, DuBois RN. WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth. Cell Cycle. 2004 Dec; 3(12):1512-5. Epub 2004 Dec 06.
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  68. Blot WJ, Fischer T, Nielsen GL, Friis S, Mumma M, Lipworth L, DuBois R, McLaughlin JK, Sorensen HT. Outcome of upper gastro-intestinal bleeding and use of ibuprofen versus paracetamol. Pharm World Sci. 2004 Dec; 26(6):319-23.
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  69. Buchanan FG, Chang W, Sheng H, Shao J, Morrow JD, DuBois RN. Up-regulation of the enzymes involved in prostacyclin synthesis via Ras induces vascular endothelial growth factor. Gastroenterology. 2004 Nov; 127(5):1391-400.
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  70. Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK, DuBois RN, Dey SK. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med. 2004 Oct; 10(10):1074-80. Epub 2004 Sep 19.
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  71. Wang D, Wang H, Shi Q, Katkuri S, Walhi W, Desvergne B, Das SK, Dey SK, DuBois RN. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell. 2004 Sep; 6(3):285-95.
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  72. Organ EL, Nalbantyan CD, Nanney LB, Woodward SC, Sheng J, Dubois RN, Price J, Sutcliffe M, Coffey RJ, Rubin DH. Effects of transforming growth factor-alpha (TGF-alpha) in vitro and in vivo on reovirus replication. DNA Cell Biol. 2004 Jul; 23(7):430-41.
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  73. Brown JR, DuBois RN. Cyclooxygenase as a target in lung cancer. Clin Cancer Res. 2004 Jun 15; 10(12 Pt 2):4266s-4269s.
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  74. Lynch TJ, Adjei AA, Bunn PA Jr, DuBois RN, Gandara DR, Giaccone G, Govindan R, Herbst RS, Johnson BE, Khuri FR, Perez-Soler R, Rosell R, Rowinsky EK, Sandler AB, Scagliotti GV, Schiller JH, Shapiro GI, Socinski MA, Hart CS. Novel agents in the treatment of lung cancer: conference summary statement. Clin Cancer Res. 2004 Jun 15; 10(12 Pt 2):4199s-4204s.
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  75. Brown JR, DuBois RN. Cyclooxygenase-2 in lung carcinogenesis and chemoprevention: Roger S. Mitchell lecture. Chest. 2004 May; 125(5 Suppl):134S-40S.
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  76. Mann JR, DuBois RN. Cyclooxygenase-2 and gastrointestinal cancer. Cancer J. 2004 May-Jun; 10(3):145-52.
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  77. Koehne CH, Dubois RN. COX-2 inhibition and colorectal cancer. Semin Oncol. 2004 Apr; 31(2 Suppl 7):12-21.
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  78. Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med. 2004 Mar; 10(3):245-7. Epub 2004 Feb 01.
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  79. Wang D, Dubois RN. Cyclooxygenase-2: a potential target in breast cancer. Semin Oncol. 2004 Feb; 31(1 Suppl 3):64-73.
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  80. Yoshinaga M, Buchanan FG, DuBois RN. 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. Prostaglandins Other Lipid Mediat. 2004 Jan; 73(1-2):111-22.
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  81. Buchanan FG, Wang D, Bargiacchi F, DuBois RN. Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor. J Biol Chem. 2003 Sep 12; 278(37):35451-7. Epub 2003 Jun 24.
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  82. Dubois RN. The physician-scientist in gastroenterology. Gastroenterology. 2003 Sep; 125(3):652.
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  83. Gupta RA, Sarraf P, Mueller E, Brockman JA, Prusakiewicz JJ, Eng C, Willson TM, DuBois RN. Peroxisome proliferator-activated receptor gamma-mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms. J Biol Chem. 2003 Jun 20; 278(25):22669-77. Epub 2003 Feb 18.
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  84. Wagenaar-Miller RA, Hanley G, Shattuck-Brandt R, DuBois RN, Bell RL, Matrisian LM, Morgan DW. Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. Br J Cancer. 2003 May 6; 88(9):1445-52.
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  85. Berger DH, O'Mahony CA, Sheng H, Shao J, Albo D, DuBois RN, Beauchamp RD. Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions. Surgery. 2003 May; 133(5):568-79.
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  86. Gupta RA, Tejada LV, Tong BJ, Das SK, Morrow JD, Dey SK, DuBois RN. Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. Cancer Res. 2003 Mar 1; 63(5):906-11.
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  87. Daikoku T, Matsumoto H, Gupta RA, Das SK, Gassmann M, DuBois RN, Dey SK. Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner. Evidence for differential function of HIFs during early pregnancy. J Biol Chem. 2003 Feb 28; 278(9):7683-91. Epub 2002 Dec 12.
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  88. Gupta RA, Sarraf P, Brockman JA, Shappell SB, Raftery LA, Willson TM, DuBois RN. Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22. J Biol Chem. 2003 Feb 28; 278(9):7431-8. Epub 2002 Dec 04.
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  89. DuBois RN. Cyclooxygenase-2 and colorectal cancer. Prog Exp Tumor Res. 2003; 37:124-37.
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  90. Lee SH, Williams MV, DuBois RN, Blair IA. Targeted lipidomics using electron capture atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 2003; 17(19):2168-76.
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  91. Gupta RA, DuBois RN, Wallace MC. New avenues for the prevention of colorectal cancer: targeting cyclo-oxygenase-2 activity. Best Pract Res Clin Gastroenterol. 2002 Dec; 16(6):945-56.
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  92. Turini ME, DuBois RN. Primary prevention: phytoprevention and chemoprevention of colorectal cancer. Hematol Oncol Clin North Am. 2002 Aug; 16(4):811-40.
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  93. Gupta RA, Dubois RN. Controversy: PPARgamma as a target for treatment of colorectal cancer. Am J Physiol Gastrointest Liver Physiol. 2002 Aug; 283(2):G266-9.
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  94. Simon LS, Smolen JS, Abramson SB, Appel G, Bombardier C, Brater DC, Breedveld FC, Brune K, Burmester GR, Crofford LJ, Dougados M, DuBois RN, Fitzgerald GA, Frishman W, Garcia Rodriguez LA, Hochberg MC, Kalden JR, Laine L, Langman MJ, Prescott SM, van de Controversies in COX-2 selective inhibition. J Rheumatol. 2002 Jul; 29(7):1501-10.
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  95. Kozak KR, Gupta RA, Moody JS, Ji C, Boeglin WE, DuBois RN, Brash AR, Marnett LJ. 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. J Biol Chem. 2002 Jun 28; 277(26):23278-86. Epub 2002 Apr 15.
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  96. Shao J, Sheng H, DuBois RN. Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells. Cancer Res. 2002 Jun 1; 62(11):3282-8.
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  97. Kawai N, Tsuji S, Tsujii M, Ito T, Yasumaru M, Kakiuchi Y, Kimura A, Komori M, Sasaki Y, Hayashi N, Kawano S, Dubois R, Hori M. Tumor necrosis factor alpha stimulates invasion of Src-activated intestinal cells. Gastroenterology. 2002 Feb; 122(2):331-9.
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  98. Turini ME, DuBois RN. Cyclooxygenase-2: a therapeutic target. Annu Rev Med. 2002; 53:35-57.
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  99. Marnett LJ, DuBois RN. COX-2: a target for colon cancer prevention. Annu Rev Pharmacol Toxicol. 2002; 42:55-80.
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  100. Stack E, DuBois RN. Role of cyclooxygenase inhibitors for the prevention of colorectal cancer. Gastroenterol Clin North Am. 2001 Dec; 30(4):1001-10.
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  101. Reese J, Das SK, Paria BC, Lim H, Song H, Matsumoto H, Knudtson KL, DuBois RN, Dey SK. Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation. J Biol Chem. 2001 Nov 23; 276(47):44137-45. Epub 2001 Sep 10.
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  102. Pyo H, Choy H, Amorino GP, Kim JS, Cao Q, Hercules SK, DuBois RN. A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2. Clin Cancer Res. 2001 Oct; 7(10):2998-3005.
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  103. Stack E, DuBois RN. Regulation of cyclo-oxygenase-2. Best Pract Res Clin Gastroenterol. 2001 Oct; 15(5):787-800.
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  104. Gupta RA, Dubois RN. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer. 2001 Oct; 1(1):11-21.
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  105. Kobayashi O, Miwa H, Watanabe S, Tsujii M, Dubois RN, Sato N. Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2001 Sep; 281(3):G688-96.
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  106. Williams CS, Sheng H, Brockman JA, Armandla R, Shao J, Washington MK, Elkahloun AG, DuBois RN. A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. Neoplasia. 2001 Sep-Oct; 3(5):428-36.
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  107. Gupta RA, Polk DB, Krishna U, Israel DA, Yan F, DuBois RN, Peek RM Jr. Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J Biol Chem. 2001 Aug 17; 276(33):31059-66. Epub 2001 Jun 07.
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  108. Gupta RA, Brockman JA, Sarraf P, Willson TM, DuBois RN. Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells. J Biol Chem. 2001 Aug 10; 276(32):29681-7. Epub 2001 Jun 07.
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  109. Zhang Z, DuBois RN. Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. Oncogene. 2001 Jul 27; 20(33):4450-6.
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  110. Mann M, Sheng H, Shao J, Williams CS, Pisacane PI, Sliwkowski MX, DuBois RN. Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth. Gastroenterology. 2001 Jun; 120(7):1713-9.
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  111. Sheng H, Shao J, Washington MK, DuBois RN. Prostaglandin E2 increases growth and motility of colorectal carcinoma cells. J Biol Chem. 2001 May 25; 276(21):18075-81. Epub 2001 Mar 12.
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  112. DuBois RN. New paradigms for cancer prevention. Carcinogenesis. 2001 May; 22(5):691-2.
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  113. Krause WF, DuBois RN. The molecular basis for prevention of colorectal cancer. Clin Colorectal Cancer. 2001 May; 1(1):47-54.
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  114. Souto EO, Miyoshi H, Dubois RN, Gores GJ. Kupffer cell-derived cyclooxygenase-2 regulates hepatocyte Bcl-2 expression in choledocho-venous fistula rats. Am J Physiol Gastrointest Liver Physiol. 2001 May; 280(5):G805-11.
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  115. Sheng H, Shao J, DuBois RN. Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells. J Biol Chem. 2001 Apr 27; 276(17):14498-504. Epub 2001 Feb 01.
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  120. Kandil HM, Dubois RN. Cclooxygenase-2 (COX-2) Protein Expression by Western Blotting. Methods Mol Med. 2001; 50:205-11.
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  121. Gupta RA, Tan J, Krause WF, Geraci MW, Willson TM, Dey SK, DuBois RN. Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13275-80.
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  122. Williams CS, Watson AJ, Sheng H, Helou R, Shao J, DuBois RN. Celecoxib prevents tumor growth in vivo without toxicity to normal gut: lack of correlation between in vitro and in vivo models. Cancer Res. 2000 Nov 1; 60(21):6045-51.
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  123. Zhang Z, Sheng H, Shao J, Beauchamp RD, DuBois RN. Posttranscriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells. Neoplasia. 2000 Nov-Dec; 2(6):523-30.
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  124. Tong BJ, Tan J, Tajeda L, Das SK, Chapman JA, DuBois RN, Dey SK. Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma. Neoplasia. 2000 Nov-Dec; 2(6):483-90.
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  125. Shao J, Sheng H, Inoue H, Morrow JD, DuBois RN. Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. J Biol Chem. 2000 Oct 27; 275(43):33951-6.
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  126. Callejas NA, Bosca L, Williams CS, DuBOIS RN, Martin-Sanz P. Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins. Gastroenterology. 2000 Aug; 119(2):493-501.
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  127. Shao J, Sheng H, DuBois RN, Beauchamp RD. Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation. J Biol Chem. 2000 Jul 28; 275(30):22916-24.
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  128. Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, Wakabayashi N, Saunders B, Shen Y, Fujimura T, Su LK, Levin B, Godio L, Patterson S, Rodriguez-Bigas MA, Jester SL, King KL, Schumacher M, Abbruzzese J, DuBois RN, Hittelman WN, Zimmerman The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med. 2000 Jun 29; 342(26):1946-52.
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  129. Williams CS, Tsujii M, Reese J, Dey SK, DuBois RN. Host cyclooxygenase-2 modulates carcinoma growth. J Clin Invest. 2000 Jun; 105(11):1589-94.
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  130. Zhang Z, DuBois RN. Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells. Gastroenterology. 2000 Jun; 118(6):1012-7.
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  131. Gupta RA, DuBois RN. Translational studies on Cox-2 inhibitors in the prevention and treatment of colon cancer. Ann N Y Acad Sci. 2000 Jun; 910:196-204; discussion 204-6.
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  132. Krause W, DuBois RN. Eicosanoids and the large intestine. Prostaglandins Other Lipid Mediat. 2000 May; 61(3-4):145-61.
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  133. Lipsky PE, Brooks P, Crofford LJ, DuBois R, Graham D, Simon LS, van de Putte LB, Abramson SB. Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease. Arch Intern Med. 2000 Apr 10; 160(7):913-20.
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  134. Dubois RN. Review article: cyclooxygenase--a target for colon cancer prevention. Aliment Pharmacol Ther. 2000 Apr; 14 Suppl 1:64-7.
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  135. Sheng H, Shao J, Dixon DA, Williams CS, Prescott SM, DuBois RN, Beauchamp RD. Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J Biol Chem. 2000 Mar 3; 275(9):6628-35.
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  136. Shattuck-Brandt RL, Varilek GW, Radhika A, Yang F, Washington MK, DuBois RN. Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice. Gastroenterology. 2000 Feb; 118(2):337-45.
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  137. Williams CS, Mann M, DuBois RN. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene. 1999 Dec 20; 18(55):7908-16.
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  138. Arber N, DuBois RN. Nonsteroidal anti-inflammatory drugs and prevention of colorectal cancer. Curr Gastroenterol Rep. 1999 Oct; 1(5):441-8.
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  139. Kamitani H, Ikawa H, Hsi LC, Watanabe T, DuBois RN, Eling TE. Regulation of 12-lipoxygenase in rat intestinal epithelial cells during differentiation and apoptosis induced by sodium butyrate. Arch Biochem Biophys. 1999 Aug 1; 368(1):45-55.
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  140. O'Mahony CA, Beauchamp RD, Albo D, Tsujii M, Sheng HM, Shao J, Dubois RN, Berger DH. Cyclooxygenase-2 alters transforming growth factor-beta 1 response during intestinal tumorigenesis. Surgery. 1999 Aug; 126(2):364-70.
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  141. Lim H, Gupta RA, Ma WG, Paria BC, Moller DE, Morrow JD, DuBois RN, Trzaskos JM, Dey SK. Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev. 1999 Jun 15; 13(12):1561-74.
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  142. Williams CS, Goldman AP, Sheng H, Morrow JD, DuBois RN. Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth. Neoplasia. 1999 Jun; 1(2):170-6.
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  143. Shattuck-Brandt RL, Lamps LW, Heppner Goss KJ, DuBois RN, Matrisian LM. Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. Mol Carcinog. 1999 Mar; 24(3):177-87.
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  144. Shao J, Sheng H, Aramandla R, Pereira MA, Lubet RA, Hawk E, Grogan L, Kirsch IR, Washington MK, Beauchamp RD, DuBois RN. Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis. 1999 Feb; 20(2):185-91.
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  145. Sheng H, Shao J, O'Mahony CA, Lamps L, Albo D, Isakson PC, Berger DH, DuBois RN, Beauchamp RD. Transformation of intestinal epithelial cells by chronic TGF-beta1 treatment results in downregulation of the type II TGF-beta receptor and induction of cyclooxygenase-2. Oncogene. 1999 Jan 28; 18(4):855-67.
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  146. Shattuck-Brandt RL, DuBois RN. The molecular basis of colorectal carcinogenesis. Curr Opin Gastroenterol. 1999 Jan; 15(1):3-8.
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  147. Williams CS, Shattuck-Brandt RL, DuBois RN. The role of COX-2 in intestinal cancer. Expert Opin Investig Drugs. 1999 Jan; 8(1):1-12.
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  148. DuBois RN. Cyclooxygenase-2 and colorectal cancer (Review). Gastroenterology International. 1999; 12:182-85.
  149. DuBois RN. Colorectal cancer: Identifying the high-risk patient (Review). Women's Health in Primary Care. 1999; 2:958-67.
  150. Williams C, Shattuck-Brandt RL, DuBois RN. The role of COX-2 in intestinal cancer. Ann N Y Acad Sci. 1999; 889:72-83.
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  151. Karnes WE Jr, Shattuck-Brandt R, Burgart LJ, DuBois RN, Tester DJ, Cunningham JM, Kim CY, McDonnell SK, Schaid DJ, Thibodeau SN. Reduced COX-2 protein in colorectal cancer with defective mismatch repair. Cancer Res. 1998 Dec 1; 58(23):5473-7.
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  152. Goldman AP, Williams CS, Sheng H, Lamps LW, Williams VP, Pairet M, Morrow JD, DuBois RN. Meloxicam inhibits the growth of colorectal cancer cells. Carcinogenesis. 1998 Dec; 19(12):2195-9.
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  153. Ethridge RT, Hellmich MR, DuBois RN, Evers BM. Inhibition of heat-shock protein 70 induction in intestinal cells overexpressing cyclooxygenase 2. Gastroenterology. 1998 Dec; 115(6):1454-63.
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  154. Brockman JA, Gupta RA, Dubois RN. Activation of PPARgamma leads to inhibition of anchorage-independent growth of human colorectal cancer cells. Gastroenterology. 1998 Nov; 115(5):1049-55.
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  155. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB, Lipsky PE. Cyclooxygenase in biology and disease. FASEB J. 1998 Sep; 12(12):1063-73.
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  156. Sheng H, Williams CS, Shao J, Liang P, DuBois RN, Beauchamp RD. Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. J Biol Chem. 1998 Aug 21; 273(34):22120-7.
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  157. Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell. 1998 May 29; 93(5):705-16.
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  158. Sheng H, Shao J, Williams CS, Pereira MA, Taketo MM, Oshima M, Reynolds AB, Washington MK, DuBois RN, Beauchamp RD. Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis. 1998 Apr; 19(4):543-9.
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  159. Giardiello FM, Spannhake EW, DuBois RN, Hylind LM, Robinson CR, Hubbard WC, Hamilton SR, Yang VW. Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis. Dig Dis Sci. 1998 Feb; 43(2):311-6.
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  160. Sheng H, Shao J, Morrow JD, Beauchamp RD, DuBois RN. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res. 1998 Jan 15; 58(2):362-6.
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  161. DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA. The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers. Carcinogenesis. 1998 Jan; 19(1):49-53.
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  162. Sheng GG, Shao J, Sheng H, Hooton EB, Isakson PC, Morrow JD, Coffey RJ Jr, DuBois RN, Beauchamp RD. A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells. Gastroenterology. 1997 Dec; 113(6):1883-91.
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  163. Chang MS, Tsai JC, Yang R, DuBois RN, Breyer MD, O'Day DM. Induction of rabbit cyclooxygenase 2 in the anterior uvea following glaucoma filtration surgery. Curr Eye Res. 1997 Nov; 16(11):1147-51.
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  164. Williams CS, Smalley W, DuBois RN. Aspirin use and potential mechanisms for colorectal cancer prevention. J Clin Invest. 1997 Sep 15; 100(6):1325-9.
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  165. Guan Y, Chang M, Cho W, Zhang Y, Redha R, Davis L, Chang S, DuBois RN, Hao CM, Breyer M. Cloning, expression, and regulation of rabbit cyclooxygenase-2 in renal medullary interstitial cells. Am J Physiol. 1997 Jul; 273(1 Pt 2):F18-26.
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  166. Sheng H, Shao J, Kirkland SC, Isakson P, Coffey RJ, Morrow J, Beauchamp RD, DuBois RN. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest. 1997 May 1; 99(9):2254-9.
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  167. Zhang T, Nanney LB, Peeler MO, Williams CS, Lamps L, Heppner KJ, DuBois RN, Beauchamp RD. Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. Cancer Res. 1997 May 1; 57(9):1638-43.
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  168. Tsujii M, Kawano S, DuBois RN. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci U S A. 1997 Apr 1; 94(7):3336-40.
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  169. Sheng H, Shao J, Hooton EB, Tsujii M, DuBois RN, Beauchamp RD. Cyclooxygenase-2 induction and transforming growth factor beta growth inhibition in rat intestinal epithelial cells. Cell Growth Differ. 1997 Apr; 8(4):463-70.
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  170. Smith B, DuBois RN. Current concepts in colorectal cancer prevention. Compr Ther. 1997 Mar; 23(3):184-9.
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  171. Watson AJ, Dubois RN. Lipid metabolism and APC: implications for colorectal cancer prevention. Lancet. 1997 Feb 15; 349(9050):444-5.
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  172. Coffey RJ, Hawkey CJ, Damstrup L, Graves-Deal R, Daniel VC, Dempsey PJ, Chinery R, Kirkland SC, DuBois RN, Jetton TL, Morrow JD. Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):657-62.
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  173. Schmedtje JF Jr, Ji YS, Liu WL, DuBois RN, Runge MS. Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J Biol Chem. 1997 Jan 3; 272(1):601-8.
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  174. Zhang T, Nanney LB, Luongo C, Lamps L, Heppner KJ, DuBois RN, Beauchamp RD. Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res. 1997 Jan 1; 57(1):169-75.
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  175. Smalley WE, DuBois RN. Colorectal cancer and nonsteroidal anti-inflammatory drugs. Adv Pharmacol. 1997; 39:1-20.
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  176. DuBois RN, Smalley WE. Cyclooxygenase, NSAIDs, and colorectal cancer. J Gastroenterol. 1996 Dec; 31(6):898-906.
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  177. DuBois RN, Giardiello FM, Smalley WE. Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention. Gastroenterol Clin North Am. 1996 Dec; 25(4):773-91.
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  178. Williams CS, Luongo C, Radhika A, Zhang T, Lamps LW, Nanney LB, Beauchamp RD, DuBois RN. Elevated cyclooxygenase-2 levels in Min mouse adenomas. Gastroenterology. 1996 Oct; 111(4):1134-40.
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  179. DuBois RN, Eberhart CF, Williams CS. Introduction to eicosanoids and the gastroenteric tract. Gastroenterol Clin North Am. 1996 Jun; 25(2):267-77.
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  180. DuBois RN, Radhika A, Reddy BS, Entingh AJ. Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors. Gastroenterology. 1996 Apr; 110(4):1259-62.
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  181. Williams CS, DuBois RN. Prostaglandin endoperoxide synthase: why two isoforms? Am J Physiol. 1996 Mar; 270(3 Pt 1):G393-400.
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  182. DuBois RN, Shao J, Tsujii M, Sheng H, Beauchamp RD. G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res. 1996 Feb 15; 56(4):733-7.
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  183. Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell. 1996 Feb 9; 84(3):431-42.
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  184. Beauchamp RD, Peeler M, DuBois RN. Management of colorectal polyps: A review (Review). Current Opinion in Gastroenterology. 1996; 12:12-17.
  185. Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 1995 Nov 3; 83(3):493-501.
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  186. Zeldin DC, DuBois RN, Falck JR, Capdevila JH. Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. Arch Biochem Biophys. 1995 Sep 10; 322(1):76-86.
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  187. Eberhart CE, Dubois RN. Eicosanoids and the gastrointestinal tract. Gastroenterology. 1995 Jul; 109(1):285-301.
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  188. Giardiello FM, Offerhaus GJ, DuBois RN. The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. Eur J Cancer. 1995 Jul-Aug; 31A(7-8):1071-6.
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  189. DuBois RN, Bishop PR, Graves-Deal R, Coffey RJ. Transforming growth factor alpha regulation of two zinc finger-containing immediate early response genes in intestine. Cell Growth Differ. 1995 May; 6(5):523-9.
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  190. Capdevila JH, Morrow JD, Belosludtsev YY, Beauchamp DR, DuBois RN, Falck JR. The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s). Biochemistry. 1995 Mar 14; 34(10):3325-37.
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  191. Barnard JA, Beauchamp RD, Russell WE, Dubois RN, Coffey RJ. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology. 1995 Feb; 108(2):564-80.
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  192. Coffey RJ, Romano M, DuBois RN. Roles of TGFα in gastric physiology and pathophysiology (Review). Proceedings from the 2nd Annual Meeting on Molecular Biological Approaches to Peptic Ulcer Disease, Medical Tribune Inc., Tokyo, Japan. 1995:27-30.
  193. Harris RC, McKanna JA, Akai Y, Jacobson HR, Dubois RN, Breyer MD. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest. 1994 Dec; 94(6):2504-10.
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  194. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 1994 Oct; 107(4):1183-8.
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  195. Barnard JA, Graves-Deal R, Pittelkow MR, DuBois R, Cook P, Ramsey GW, Bishop PR, Damstrup L, Coffey RJ. Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family. J Biol Chem. 1994 Sep 9; 269(36):22817-22.
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  196. DuBois RN. Can we prevent colorectal cancer? Dig Dis. 1994 Sep-Oct; 12(5):255-8.
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  197. DuBois RN, Tsujii M, Bishop P, Awad JA, Makita K, Lanahan A. Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells. Am J Physiol. 1994 May; 266(5 Pt 1):G822-7.
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  198. DuBois RN. Activin A and hepatocyte growth regulation. Hepatology. 1994 Mar; 19(3):788-90.
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  199. DuBois RN, Awad J, Morrow J, Roberts LJ 2nd, Bishop PR. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester. J Clin Invest. 1994 Feb; 93(2):493-8.
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  200. Karara A, Makita K, Jacobson HR, Falck JR, Guengerich FP, DuBois RN, Capdevila JH. Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. J Biol Chem. 1993 Jun 25; 268(18):13565-70.
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  201. Collins JF, Honda T, Knobel S, Bulus NM, Conary J, DuBois R, Ghishan FK. Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2). Proc Natl Acad Sci U S A. 1993 May 1; 90(9):3938-42.
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  202. Capdevila JH, Wei S, Yan J, Karara A, Jacobson HR, Falck JR, Guengerich FP, DuBois RN. Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading. J Biol Chem. 1992 Oct 25; 267(30):21720-6.
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  203. Holt PR, DuBois RN Jr. In vivo immediate early gene expression induced in intestinal and colonic mucosa by feeding. FEBS Lett. 1991 Aug 5; 287(1-2):102-4.
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  204. DuBois RN, McLane MW, Ryder K, Lau LF, Nathans D. A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. J Biol Chem. 1990 Nov 5; 265(31):19185-91.
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  205. DuBois RN, Lazenby AJ, Yardley JH, Hendrix TR, Bayless TM, Giardiello FM. Lymphocytic enterocolitis in patients with 'refractory sprue'. JAMA. 1989 Aug 18; 262(7):935-7.
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  206. DuBois RN, Hill KE, Burk RF. Antioxidant effect of acetaminophen in rat liver. Biochem Pharmacol. 1983 Sep 1; 32(17):2621-2.
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  207. Kramer RE, Du Bois RN, Simpson ER, Anderson CM, Kashiwagi K, Lambeth JD, Jefcoate CR, Waterman MR. Cell-free synthesis of precursor forms of mitochondrial steroid hydroxylase enzymes of the bovine adrenal cortex. Arch Biochem Biophys. 1982 May; 215(2):478-85.
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  208. John ME, DuBois RN, Waterman MR. Altered heme environments in opossum and rabbit methemoglobins. Z Naturforsch C. 1981 Nov-Dec; 36(11-12):964-7.
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  209. DuBois RN, Simpson ER, Kramer RE, Waterman MR. Induction of synthesis of cholesterol side chain cleavage cytochrome P-450 by adrenocorticotropin in cultured bovine adrenocortical cells. J Biol Chem. 1981 Jul 10; 256(13):7000-5.
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  210. DuBois RN, Simpson ER, Tuckey J, Lambeth JD, Waterman MR. Evidence for a higher molecular weight precursor of cholesterol side-chain-cleavage cytochrome P-450 and induction of mitochondrial and cytosolic proteins by corticotropin in adult bovine adrenal cells. Proc Natl Acad Sci U S A. 1981 Feb; 78(2):1028-32.
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  211. Dubois RN, Waterman MR. Effect of phenobarbital administration to rats on the level of the in vitro synthesis of cytochrome P-450 directed by total rat liver RNA. Biochem Biophys Res Commun. 1979 Sep 12; 90(1):150-7.
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