Overview

  • Fistulograms depicting the typical venous stenosis (arrow) at the vein-to-graft anastomosis

    Fistulograms depicting the typical venous stenosis (arrow) at the vein-to-graft anastomosis

  • The gross specimen showing the thickened venous anastomosis

    The gross specimen showing the thickened venous anastomosis

  • 10X H and E of the venous stenosis

    10X H and E of the venous stenosis

  • 40 X showing increased neointima

    40 X showing increased neointima

  • Adventitial migration of fibroblasts to the neointima under hypoxic stimulus with MMP-2 and MMP-9 expression

    Adventitial migration of fibroblasts to the neointima under hypoxic stimulus with MMP-2 and MMP-9 expression

  • Venous stenosis formation in a pig model of hemodialysis graft failure at day 14

    Venous stenosis formation in a pig model of hemodialysis graft failure at day 14

  • Blood outgrowth endothelial cell (BOEC) delivery to the adventitia reduces restenosis when compared to control at two weeks

    Blood outgrowth endothelial cell (BOEC) delivery to the adventitia reduces restenosis when compared to control at two weeks

The Vascular and Interventional Radiology lab is interested in understanding the mechanisms for hemodialysis graft failure. In order to accomplish this, the laboratory uses multiple different animal models of hemodialysis graft failure to test different hypotheses to determine whether they are implicated in venous neointimal hyperplasia. The ultimate goal of this research is to improve outcomes in patients suffering from end-stage renal disease by developing novel therapies which can be delivered by image guided intervention.