Muscular Dystrophy

Many muscular dystrophy subtypes are associated with systemic metabolic dysfunction. Dr. Doles' research team is interested in how skeletal muscle dysfunction contributes to altered homeostasis in nonmuscle tissues such as liver and fat. Ongoing projects include studies of adipocyte precursor cells derived from murine Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD) models as well as metabolic characterization of the dystrophic SC niche.