About the Lab
The Renovascular Disease Laboratory of Lilach O. Lerman, M.D., Ph.D., focuses on the development and application of techniques to study renal and cardiovascular physiology and pathophysiology in animal models and in humans.
Areas of interest
Specific areas of interest in Dr. Lerman's lab include:
- Pathophysiology of renovascular disease, hypertension and cardiac adaptation
- Cardiorenal interactions and the kidney and myocardial microcirculation
- Development and application of cell-based therapy for renal microvascular repair
- The effects of cardiovascular risk factors (such as early atherosclerosis, metabolic syndrome and obesity) on myocardial microvascular function, remodeling and adaptation to upstream coronary artery stenosis
- Potential benefits of chronic supplementation with novel drugs (such as anti-inflammatories and antioxidants) on the ischemic kidney and heart
- Development, interpretation and implementation of physiologiccal imaging and image analysis techniques using multidetector computerized tomography (MDCT) and magnetic resonance imaging (MRI)
Dr. Lerman's Renovascular Disease Lab is involved in short-term and long-term studies with research tools that include wet-lab methods and sophisticated high-resolution CT, MRI, computer-based modeling and image analysis.
Disease mechanisms are often initially investigated in vivo using imaging, and subsequently correlated with tissue alterations determined with molecular biology and cell culture techniques.
The Renovascular Disease Lab is exploring potential therapeutic targets and interventions that include regenerative medicine, revascularization and novel drugs.
Dr. Lerman's lab is affiliated with several departments and research labs at Mayo Clinic: