The application of nanotechnology in biology and medicine, called biomedical nanotechnology, is a burgeoning field that brings with it a myriad of opportunities and possibilities for advancing medical science and disease treatment. This multidisciplinary field spans the disciplines of biology, chemistry, materials science, engineering and medicine.
At the nanoscale, the physico-chemical properties of materials (e.g., metals, semiconductors) differ fundamentally from their corresponding bulk counterpart because of the quantum size effect.
While metallic gold is the well-known golden yellow, gold nanoparticles (AuNPs) can change their characteristic from a wine red color to pink, violet, or blue simply by altering their size and shape. With this flexibility, nanoparticles also have a large surface area capable for the loading of multiple diagnostic (such as optical, radioisotope, magnetic) and therapeutic (such as drugs) agents.
These two fundamental characteristics of gold nanoparticles render them an attractive research tool. Therefore, understanding the basic molecular interactions between nanoparticles and biomolecules is important and essential to successfully apply nanotechnology to biomedical applications.
To achieve this goal, our group is pursuing three major areas:
- Protein-nanoparticle interactions and their implication in angiogenesis-dependent disorder.
- Cell-nanoparticle interactions and their implication in targeted therapy.
- Synthesis of differently shaped nanoparticles based on their protein structure and application in biology.