Class A G Protein-Coupled Receptor (GPCR) Projects

Class A G Protein-Coupled Receptor (GPCR) Projects

  • Use of photoaffinity labeling and mutagenesis to explore the molecular basis of natural cholecystokinin (CCK) ligand binding to its receptor and refine our understanding of the structure of ligand-receptor complexes in active and inactive states (as well as molecular modeling of these complexes).
  • Use of fluorescence to probe microdomains involved in CCK ligand binding, as well as conformational changes associated with receptor activation.
  • Structure-based rational design and optimization of CCK receptor-active drugs, including both orthosteric and allosteric ligands.
  • Analysis of the impact of the lipid microenvironment on CCK receptor structure and function.
  • Applications of CCK receptor-active drugs for the control of appetite and obesity.