Inflammation and Cancer

The molecular hepatology laboratory of Tushar C. Patel, M.B., Ch.B., is interested in understanding the mechanisms by which chronic inflammation promotes carcinogenesis of the biliary tract.

In one project, which is funded by the National Institutes of Health, Dr. Patel and his team are studying the cellular processes by which inflammatory cytokines, such as interleukin-6, can foster tumor formation and growth in the liver by altering gene expression or modulating cell responses that enable malignant transformation.

Dr. Patel's research group has made several important observations about cytokine-dependent signaling mechanisms and gene expression involved in tumorigenesis. Ongoing efforts are focused on evaluating therapeutic strategies that target these mechanisms.