The primary focus of the artificial pancreas program in the Integrated Carbohydrate Physiology and Translation Lab at Mayo Clinic is conducting experiments designed to better understand the effects of daily factors that influence glucose control and variability in people with type 1 diabetes.
A better understanding of these factors can then inform and refine a closed-loop control algorithm that would continually be individualized for each patient with type 1 diabetes.
Research in the Integrated Carbohydrate Physiology and Translation Lab has come full circle in an attempt to close the loop for type 1 diabetes, and investigators Ananda Basu, MBBS, M.D., and Rita Basu, M.D., hope to accelerate approval of the closed-loop artificial endocrine pancreas for treatment of type 1 diabetes mellitus.
By implementing closed-loop studies, the research team can study, define, understand and develop physiological models of integrative physiology related to the insulin-glucose system in people with type 1 diabetes.
A better understanding of the insulin-glucose system as it relates to meals, physical activity and other factors, such as menstrual or sleep cycles, will help inform, develop, refine and validate personalized, state-of-the-art closed-loop artificial pancreas systems to improve the quality of life in people with type 1 diabetes.
Drs. Ananda Basu and Rita Basu want to improve existing methods and develop innovative techniques to measure physiological parameters related to these variables.