Remote Physiologic Monitoring Program

The Human Integrative Environmental Physiology Laboratory has an extensive history of studying and developing remote monitoring equipment, with research dating back to the early 2000s.

We have partnered with many groups to develop specialized equipment for our expeditions. We now also work with groups that make mobile health devices, helping them improve the quality of their equipment and algorithms.

The Remote Physiologic Monitoring Program has several ongoing research projects.

Project LevEL

In this project, Dr. Johnson's lab is collaborating with Lev El Diagnostics of Heart Diseases Ltd., a private biomedical company specializing in the detection of cardiovascular disease, on a clinical trial of HeartTrends. The HeartTrends device uses an algorithm to determine if a patient has cardiac ischemia based off of 60 minutes of resting electrocardiogram data from a three-lead Holter monitor.

Our lab is comparing detection of ischemia using HeartTrends to the current standard assessment techniques of an exercise test electrocardiogram and pre- and post- exercise echocardiograms.

Project Alife

This is a collaboration with Mikropis Inc., a European app development company that wants to create a comprehensive wellness coach application.

The objective of this project is to support wellness anytime and anywhere by connecting human behavior with scientific data and insights from mobile monitoring platforms and allowing users to create their own personal wellness pals.

Exhaled Breath Condensate Metabolomics

This is a pilot study in collaboration with the Mayo Clinic Metabolomics Resource Core. We are studying whether metabolites or other substances can be identified in exhaled breath condensate that could be used to distinguish patients with heart failure who are stable, patients with heart failure who are decompensated and healthy individuals.

The ultimate goal of this research is to determine if there are novel patterns or biomarkers that can be used as point-of-care tests for tracking disease status in patients with heart failure.

Mobile Sock

The objective of this collaborative project with the University of Minnesota is to create a remote monitoring sock that can sense changes in blood volume and motion, enabling at-home identification of patients with heart failure who may be at risk of decompensation.

Preventice BodyGuardian Validation

We are working to validate data collected by BodyGuardian, a novel remote care platform made by Preventice, a health care software company.

BodyGuardian incorporates an adhesive strip sensor with in-built electrodes attached to a rechargeable module that can determine an electrocardiogram (ECG) signal and bioimpedance. The module also has a three-way accelerometer. ECG, physical activity and respiration can be assessed using these sensors.

In this project, our lab is measuring breathing and activity level using the BodyGuardian device and validating these measurements to the gold standard measurement techniques of gas exchange using a mouthpiece connected to flow and gas analyzers. We will then work to improve on the measurements from the current version of BodyGuardian.

Cardiac Resynchronization of Pacemakers

Pacemakers are automatically set to specific atrioventricular contraction timings based on normalized data, not individualized data.

The objective of this project is to use exercise and gas exchange techniques combined with monitoring over time to develop more-individualized cardiac synchronization for pacemakers.

Jawbone Algorithm Development

The objective of this project is to help Jawbone, a leader in data-driven wearable technology, create its newest prototype wristband called Jawbone UP3.

The Jawbone wristband is worn to track activity and sleep quality and to measure heart rate and breathing rate.