About the Lab

The Human Integrative and Environmental Physiology Laboratory of Bruce D. Johnson, Ph.D., at Mayo Clinic researches human health and disease in extreme conditions, and applies that to optimize performance and health in everyday life.

In Dr. Johnson's lab, we have three major branches of research:

  • Cardiovascular diseases
  • Remote physiologic monitoring
  • Optimization of performance and health

Within these research areas, we focus on health and physiology in extreme environments and situations. Research involves the study of healthy people in extreme conditions, such as reduced gravity or high-altitude environments, and in situations of exceptional mental or physical stress, such as high-level competition or emergency response.

In addition, our Human Integrative and Environmental Physiology Lab studies people with diseases that cause ongoing physical stress, such as pulmonary arterial hypertension or heart failure.

Our research team is driven by the desire to learn more about how unusual and extreme conditions affect physiology and how to best monitor resulting physiologic changes. Our lab uses that information to optimize health and performance.

We work to find simple and efficient ways to overcome complex challenges, such as analyzing exhaled breath patterns to detect declining status in patients with heart failure, developing mobile health apps to serve as personal health coaches, and creating better wearable technology to help measure and improve health indexes and monitor patients to reduce hospital admissions.