Selected Publications

  • Lollar P, Owen WG. Clearance of thrombin from circulation in rabbits by high-affinity binding sites on endothelium. J Clin Invest 66:1222-1230, 1980.
  • Esmon C.T. and Owen W.G. Identification of an endothelial cell cofactor for thrombin?catalyzed activation of protein C. Proc. Natl. Acad. Sci. USA 78: 2249-2252, 1981.
  • Owen WG, Esmon CT. Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. J Biol Chem 256:5532-5535, 1981.
  • Esmon NL, Owen WG, Esmon CT. Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C. J Biol Chem 257:859-864, 1982.
  • Hoylaerts M, Owen WG, Collen D. Involvement of heparin chain length in the heparin-catalyzed inhibition of thrombin by antithrombin III. J Biol Chem 259:5670-5677, 1984.
  • Machovich R, Owen WG. An elastase-dependent pathway of plasminogen activation. Biochemistry 28:4517-4522, 1989.
  • Fay WP, Owen WG. Platelet plasminogen activator inhibitor:purification and characterization of interaction with plasminogen activators & activated protein C. Biochemistry 28:5773-78, 1989.
  • Jakubowski HV, Owen WG. Macromolecular specificity determinants on thrombin for fibrinogen and thrombomodulin. J Biol Chem 264:1117-1121, 1989.
  • Tefferi A, Owen BA, Nichols WL, Witzig TE, Owen WG. Isolation of a heparin-like anticoagulant from the plasma of a patient with metastatic bladder carcinoma. Blood 74:252-254, 1989.
  • Owen BA, Owen WG. Interaction of factor Xa with heparin does not contribute to the inhibition of factor Xa by antithrombin III-heparin. Biochemistry 29:9412-9417, 1990.
  • Machovich R, Litwiller RD, Owen WG. Requirement of zymogen modification for activation of porcine plasminogen. Biochemistry 31:11558-11561, 1992.
  • Zoldhelyi P, Chesebro JH, Owen WG. Hirudin as a molecular probe for thrombin in vitro and during systemic coagulation in the pig. Proc Natl Acad Sci USA 90:1819-1823, 1993.
  • Felsch JS, Owen WG. Endogenous antithrombin associated with microvascular endothelium. Quantitative analysis in perfused rat hearts. Biochemistry 33:818-822, 1994.
  • Owen WG, Bichler J, Ericson D, Wysokinski W. Gating of thrombin in platelet aggregates by pO2-linked lowering of extracellular Ca2+. Biochemistry 34:9277-9281, 1995.
  • McBane RD, Wysokinski WE, Chesebro JH, Owen WG. Antithrombotic action of endogenous porcine protein C activated with a latent porcine thrombin preparation. Thromb Haemost 74:879-885, 1995.
  • Wysokinski W, McBane R, Chesebro JH, Owen WG. Reversibility of platelet thrombosis in vivo Quantitative analysis in porcine carotid arteries. Thromb Haemost 76:1108-1113, 1996.
  • O’Marcaigh AS, Nichols WL, Hassinger NL, Mullins JD, Mallouh AA, Gilchrist GS, Owen WG. Genetic analysis and functional characterization of prothrombins Corpus Christi (Arg382-Cys), Dhahran (Arg271-His) and hypoprothrombinemia. Blood 88:2611-2618, 1996.
  • Bichler¸ J, Heit JA, Owen WG. Detection of thrombin in human blood by ex vivo hirudin. Thromb. Res. 84: 289-294, 1996.
  • Machovich R, Ajtai K, Owen WG. Myosin as cofactor and substrate in fibrinolysis. FEBS Lett 07: 93-96, 1997.
  • Machovich R, Owen WG. Denatured proteins as cofactors for plasminogen activation. Arch Biochem Biophys 344:343-349, 1997.
  • McBane RD, Miller RS, Hassinger NL, Nemerson Y, Chesebro JH, Owen WG. Tissue Prothrombin: universal distribution in vascular smooth muscle. Arterioscl Thrombos Vasc Biol 17: 2430-2436, 1997.
  • Wysokinski W, McBane RD, Owen WG. Individual propensity for arterial thrombosis. Arteriosclerosis, Thromb Vasc Biol 19: 883-886, 1999.
  • Smith RD, Owen WG. Platelet responses to compound interactions with thrombin. Biochemistry 38, 8936 -8947, 1999.
  • McBane RD, Ford MAP, Karnicki K, Stewart ML, Owen WG. Fibrinogen, fibrin and crosslinking in aging arterial thrombi. Thromb Haemostas 84: 83-87, 2000.
  • Luyer MDP, Khosla S, Owen WG, Miller VM. Prospective randomized study of effects of unopposed estrogen replacement therapy on markers of coagulation and inflammation in postmenopausal women. J Clin Endocrinol Metab 86:3629-3634, 2001.
  • Karnicki K, Komorowicz E, Fass DN, Owen WG, McBane RD. Influence of anatomical location on arterial thrombosis. Arterioscler Thromb Vasc Biol 22:342-347, 2002.
  • Karnicki K, Owen WG, Miller RS, McBane RD. Factors contributing to an individual propensity for arterial thrombosis Arterioscler Thromb Vasc Biol 22: 1495-1499, 2002.
  • Cassiday LA, Lebruska LL, Benson LM, Naylor S, Owen WG, Maher LJ. Binding stoichiometry of an RNA aptamer and its transcription factor target. Anal Biochem 306; 290–297, 2002.
  • Jayachandran M, Owen WG, Miller VM. Effects of ovariectomy on aggregation, secretion, and metalloproteinases in porcine platelets. Am J Physiol 284: H1679–H1685, 2003.
  • Jiménez TM, Patel SB, Pineda AA, Tefferi A, Owen WG. Factors that Influence Platelet Recovery after Transfusion: Resolving donor quality from ABO compatibility Transfusion 43; 328-334, 2003.
  • McBane,RD.II, Karnicki K, Tahirkheli N, Miller RS, Owen WG. Platelet Characteristics Associated with Coronary Artery Disease. J Thromb Haemost 1; 1296-1303, 2003.
  • Go RS, Ritman EL, Owen WG. Angiogenesis in rat aortic rings stimulated by very low concentrations of serum and plasma. Angiogenesis 6: 25–29, 2003.
  • Owen WG. PAR3 is a low affinity substrate, high affinity effector of thrombin. Biochem Biophys Res Comm 305: 166-168, 2003.
  • Esmon CT, Owen WG. The discovery of thrombomodulin. J Thromb Haemost 2: 209-213, 2004.
  • McBane RD 2nd, Karnicki K, Miller RS, Owen WG. The Impact of peripheral arterial disease on circulating platelets. Thromb Res 113:137-145, 2004.
  • Wysokinski WE, Owen WG, Fass DN, Patrzalek DD, Murphy L, McBane RD 2nd. Atrial fibrillation and thrombosis: immunohistochemical differences between in situ and embolized thrombi. J Thromb Haemost 2:1637-1644, 2004.
  • Jayachandran M, Okano H, Chatrath R, Owen WG, McConnell JP, Miller VM. Sex-specific changes in platelet aggregation and secretion with sexual maturity in pigs. J Appl Physiol 97:1445-1452, 2004
  • Karnicki K, McBane RD 2nd, Miller RS, Leadley RJ, Jr, Morser J, Owen WG, Chesebro JH. Inhibition and reversal of platelet-rich arterial thrombus in vivo: direct vs. indirect factor Xa inhibition. J Thromb Haemost 2:2162-2169, 2004.
  • Heit JA, Petterson TM, Owen WG, Burke JP, de Andrade M, Melton LJ 3rd. Thrombomodulin gene polymorphisms or haplotypes as potential risk factors for venous thromboembolism: a population-based case-control study. J Thromb Haemost 3:710-717, 2005.
  • Owen WG. Big piece, little piece or: yes, factor VIII is a protein. J Thromb Haemost 3:1905-1909, 2005.
  • Jayachandran M, Karnicki K, Miller RS, Owen WG, Korach KS, Miller VM. Platelet characteristics change with aging: role of estrogen receptor beta. J Gerontol A Biol Sci Med Sci 60:815-819, 2005.
  • Jayachandran M. Mukherjee R, Steinkamp T, LaBreche P, Bracamonte MP, Okano H, Owen WG, Miller VM. Differential effects of 17 beta-estradiol, conjugated equine estrogen, and raloxifene on mRNA expression, aggregation, and secretaion in platelets. Am J Physiol Heart Circ Physiol 288:H2355-62, 2005.
  • Jayachandran M, Sanzo A, Owen WG, Miller VM. Estrogenic regulation of tissue factor and tissue factor pathway inhibitor in platelets. Am J Physiol Heart Circ Physiol 289:H1908-16, 2005.