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The Mayo Clinic Cell and Regenerative Physiology Lab characterizes diaphragm motor units to show how they accomplish different diaphragm behaviors.
The lab examines mechanisms underlying weakness in different muscle fiber types to understand how muscle weakness impacts multiple diseases, conditions and treatments.
Dr. Sieck's laboratory investigates age-related muscle fiber atrophy and weakness (sarcopenia) in diaphragm muscle fibers to understand how it impacts respiratory neuromotor control.
The Cell and Regenerative Physiology Laboratory is researching how rhythmic diaphragm muscle activity can be restored in these patients with spinal cord injury.
Dr. Sieck's research team studies the neural control of airway smooth muscle — specifically the pathophysiology and remodeling characteristic of asthma.
The Cell and Regenerative Physiology Laboratory works with numerous collaborators within and external to Mayo Clinic.
Dr. Sieck's research has been continuously funded by multiple grants from the National Institutes of Health for more than 35 years.
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