Polycystic kidney disease (PKD): Vascular abnormalities

The overall aim of the Cardiovascular Molecular Imaging Laboratory's PKD vascular project is to investigate the vascular abnormalities in polycystic kidney disease.

Dr. Rodriguez-Porcel's lab is using state-of-the-art imaging modalities, including micro-CT, micro-ultrasound and optical molecular imaging, to verify the hypothesis that vascular abnormalities are a primary problem in PKD.

Polycystic kidney disease is the most common inherited renal cystic disease, and is characterized by renovascular and renal tubular derangements, with no effective and approved therapy.

The goal of the lab's research is to develop novel therapeutic targets that can lead to better interventions to restore renal function and structure in PKD. The potential new interventions the lab is studying may also complement others currently under investigation.

In this project, the lab works in close collaboration with the Mayo Clinic Translational Polycystic Kidney Disease (PKD) Center, Vicente E. Torres, M.D., Ph.D., and Peter C. Harris, Ph.D., nationally and internationally recognized experts in PKD. This close collaboration ensures that this project is incorporated with other scientific advancements in this field.