• Myocardial infarction. This study uses community surveillance to investigate the incidence and outcomes of coronary disease, including both myocardial infarction and unstable angina.
  • Heart failure. This study examines the incidence and outcomes of heart failure within a community-based setting. In particular, it focuses on describing the epidemic of hospitalizations occurring in heart failure patients by investigating causes for frequent hospitalizations and other health care utilization.
  • Cardiovascular Disease Specimen Repository (CaDRe). This study maintains a DNA biobank of consenting patients from the myocardial infarction and heart failure cohorts. Prospective recruitment of eligible patients with suspect heart disease for genetic studies with subsequent clinical validation of disease status is ongoing.
  • Atrial fibrillation. This study describes the trends in atrial fibrillation incidence, treatment and survival. It investigates the impact of rate versus rhythm control on overall and stroke-free survival within a community-based setting whereby the clinical management of atrial fibrillation is not randomized.
  • Multiscale biology of atherosclerosis in the cellular adhesion pathway. This project is a substudy of the Multiethnic Study of Atherosclerosis (MESA). The goal is to investigate the biological interactions and regulation of cellular adhesion pathway components to improve understanding of these mechanisms on subclinical atherosclerotic disease.