About the Lab

The Cardiovascular Disease and Aging Laboratory of Jordan D. Miller, Ph.D., at Mayo Clinic in Rochester, Minnesota, researches the identification of novel mechanisms that contribute to age-related cardiovascular diseases in order to develop new treatments for cardiovascular disease.

Areas of research in Dr. Miller's Cardiovascular Disease and Aging Lab include:

  • Understanding mechanisms that contribute to aortic valve and atherosclerotic plaque calcification
  • Identifying novel mechanisms that contribute to mitral valve prolapse
  • Understanding mechanisms that contribute to blood vessel dysfunction with aging and vascular disease
  • Identifying biological mechanisms that contribute to impaired ability to recover from cardiovascular surgery

Since its inception, Dr. Miller's laboratory has used molecular screening of human tissue, novel strains of genetically altered mice, and in vitro and cell culture models of disease to identify novel mechanisms of human disease that might be conducive to drug targets for new treatments of cardiovascular disease.

Dr. Miller has formed multidisciplinary collaborations throughout Mayo Clinic to successfully launch a clinical trial focused on slowing progression of heart valve disease. Dr. Miller's Cardiovascular Disease and Aging Lab is dedicated to moving research findings from bench to bedside as rapidly as possible.