Establishment and Characterization of New Preclinical Cell Models
Histology staining of patient tissue showing a spindle/giant cell subtype of anaplastic thyroid carcinoma and a live image of its derived cell line
Tumor tissues that are surgically removed can be used for much more than just diagnosis and drug screening. These samples can be processed into in vitro models for the creation of cell lines that mimic the properties of the original tumor tissue.
Once created, these immortalized cancer cell lines can serve as the foundation for new drug treatments, identification of novel genes in cancer and a better understanding of certain subtypes of cancer.
The laboratory of John A. Copland, Ph.D., has access to hundreds of patient tumor samples from which it is trying to establish cell lines. The cell lines created in the lab will adhere to a higher standard of validity, as the lab has recently discovered that many established cell lines are actually cross-contaminated by another more aggressive cell line.
Due to this discovery, the cell models the lab produces can be directly compared and DNA-fingerprinted to the original patient tissue. In collaboration with clinicians across the country, the lab can create validated cell models that will pave the way for better cancer treatment in the future.